Icahn School Of Medicine At Mount Sinai

This study tested whether ertugliflozin, a diabetes drug, can reduce excess fluid in the skin and tissues of people with heart failure without lowering blood volume. 28 adults with reduced pumping function took the drug or a placebo in a crossover design. The goal was to see if t…

This study looked at whether changing antipsychotic medication can better control schizophrenia symptoms in people already taking these drugs. Researchers followed 219 adults with schizophrenia or schizoaffective disorder who still had symptoms despite treatment. The main measure…

This study tested whether adding an experimental drug (CCR2/5-inhibitor or anti-IL-8) to the immunotherapy nivolumab before and after surgery could help shrink tumors and improve long-term survival in people with non-small cell lung cancer or liver cancer. 48 participants receive…

This early-phase trial tested a combination of four therapies to see if they could safely boost the immune system to fight cancer. 17 adults with non-Hodgkin's lymphoma, metastatic breast cancer, or head & neck cancer received low-dose radiation and two immune-boosting drugs inje…

This study tested a special monitoring program to help teenagers who had a liver transplant take their anti-rejection medicine on time. The goal was to reduce the chance of organ rejection. The study included 148 teens who were already having trouble sticking to their medication.…

This study tested a drug called bimekizumab in 60 adults with moderate-to-severe plaque psoriasis who had not improved with other similar treatments. The drug works by blocking certain inflammatory substances in the body to reduce skin redness, scaling, and thickness. The main go…

This study tested whether nintedanib, a drug used for other lung diseases, can slow down lung damage in people who had severe COVID-19. It included 103 adults who still had lung problems more than 30 days after their COVID diagnosis. The main goal was to see if the drug helped ma…

This pilot study tested whether offering HIV prevention medication (PrEP) to high-risk patients in the emergency department is practical and acceptable. Twenty-six adults who were HIV-negative and medically stable were screened and given a starter pack of PrEP pills. The goal was…

This study looked at whether music therapy sessions could help people with depression feel better and become more resilient. 84 participants aged 8 to 70 with depression took part in weekly music therapy or wellness concerts for three months. Researchers measured changes in depre…

This study tested whether a special type of lighting, called a tailored lighting intervention, could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. Sixty-one participants living in assisted living or nursing ho…

This study looked at whether a recreational ballet program called Ballet for all Kids can help children with autism spectrum disorder (ASD) improve their motor skills. 32 children aged 6-12 with ASD participated in the program for 12 weeks. Researchers measured changes in coordin…

This study tested two drugs, epinephrine and dexmedetomidine, added to standard spinal anesthesia for planned C-sections. 90 pregnant women participated to see which drug provides longer pain relief and faster recovery of movement. The goal is to improve comfort and shorten recov…

This study tested whether a long-term light treatment could improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used a special light device, and researchers measured changes in thinking skills and sleep qua…

This study tested whether music therapy singing sessions could improve memory, language, and quality of life in people with Alzheimer's disease or mild cognitive impairment. Over 12 months, 100 participants worked with a licensed music therapist and were compared to a control gro…

This study tested two types of pain-relief injections (liposomal bupivacaine vs. standard bupivacaine) given during open fibroid surgery. 140 women participated to see which method reduced the need for opioid painkillers after the operation. The goal was to improve pain control a…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This study tested a shorter radiation treatment schedule for head and neck cancer in people aged 70 and older. Instead of daily visits for 6-7 weeks, the goal was to reduce side effects and help patients complete treatment. The study enrolled 37 participants and looked at whether…

This study tested whether a special light treatment could improve thinking, sleep, and metabolism in 25 people with mild cognitive impairment or mild Alzheimer's disease who also had sleep problems. Participants lived at home and were not blind or on insulin for diabetes. The res…

This study tested whether a special light therapy, used for 6 months, could improve sleep, mood, thinking, and daily behavior in 100 people with Alzheimer's disease or mild cognitive impairment. Participants either received the active light treatment or a placebo light. The goal …

This study looked at whether different lengths of light exposure can improve sleep, mood, and agitation in people with Alzheimer's disease. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to see which light schedule work…

This study tested whether a low-level magnetic therapy device, used at home, is safe and practical for people with Long COVID who have memory and thinking problems. Thirty adults with persistent cognitive issues after COVID-19 used the device daily for 4 weeks, then were followed…

This study looked at 104 patients to find the optimal number of tissue samples (biopsies) to take during a pleuroscopy, a procedure to examine the lining of the lungs. The goal was to see how many biopsies are needed to make a diagnosis and to get enough tissue for further testin…

This completed study tested whether sotagliflozin, a dual SGLT1/2 inhibitor, reduces blood clot formation better than empagliflozin, a standard SGLT2 inhibitor. Seventeen healthy volunteers took each drug for one month in a crossover design. Researchers measured clot size and pla…

This completed study surveyed 93 adults with incurable, advanced bladder cancer to find out what supportive care and educational needs they have. Participants filled out a questionnaire covering topics like emotional support, information needs, and daily living challenges. The go…

This study measured the amount of xylazine—a dangerous animal sedative often mixed with opioids—in the blood and urine of 75 emergency room patients who had a non-fatal opioid overdose. The goal was to see how common xylazine is and how well test strips can detect it. The finding…

This study looked at whether a less invasive type of liver surgery leads to better results for patients. Researchers analyzed data from over 9,000 adults who had liver surgery between 2022 and 2023. They focused on key outcomes like death within 30 days, infections, readmission t…

This study tested a new brain-training method to help people with heroin addiction reduce cravings. Participants watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further along in recovery. The goa…

This study looked at 15 people with changes in the DDX3X gene, a known cause of intellectual disability and sometimes autism. Researchers used interviews, play-based assessments, and genetic tests to better understand the condition. The goal was to describe the range of symptoms,…

This completed Phase 1 trial looked at how cannabidiol (CBD) is absorbed and processed in 24 healthy adults. Researchers gave different doses of CBD and measured its levels in blood and urine, along with any side effects. The goal was to understand the drug's pharmacokinetics, no…

This small study tested whether a special light program on an iPad can suppress melatonin, a hormone that helps control sleep. Ten healthy adults over 30 used the Circadian OS software, and researchers measured their melatonin levels and sleepiness. The goal was to see if this te…

This study looked at heart and lung function in 106 people with ME/CFS to better understand post-exertional malaise (PEM) — the severe fatigue and symptom flare after physical activity. Participants did two days of maximal exercise tests, and those with low blood volume on day on…

This study tested a web-based app called STOMA Care to see if it is practical and helpful for bladder or colorectal cancer patients getting ostomy surgery and their family caregivers. Researchers measured how well the app worked by tracking recruitment, retention, and changes in …

This study looked at pressure inside the kidney during surgery to remove kidney stones. Doctors compared two methods: one using a tube that also suctions out stone dust, and one without suction. The goal was to see how pressure changes, which could affect safety and how well ston…

This study looked at whether text message reminders help people over 55 with normal thinking skills follow a daily morning light routine. The light is meant to help reset the body's internal clock. Twenty healthy adults took part, and researchers measured their light exposure and…

This study looked at 108 adults having surgery for kidney stones. Doctors compared using a special balloon catheter versus a standard tube to see which one better stops small stone pieces from falling into the ureter. The goal was to find out if the balloon tool offers any advant…

This study tested a new online tool called the Personal Patient Profile for Bladder Cancer (P3-BC) to help patients facing bladder removal surgery make better decisions with their doctors. 24 adults with bladder cancer participated to see if the tool was easy to use and helpful. …

This study looked at how eating and fasting affect self-control in women with and without bulimia nervosa. Researchers used brain scans and computer tasks to see differences in behavior and brain activity. The goal was to better understand what drives bulimia symptoms. 100 adult …

This study looked at how the brain and body change during hypnosis. Fifty healthy adults completed a standard hypnosis test while wearing sensors to measure brain waves and other signals. The goal was to collect data that will help create a machine learning tool to recognize when…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…