Study probes why ME/CFS patients crash after exercise
NCT ID NCT04740736
First seen Jan 05, 2026 · Last updated Jun 19, 2026 · Updated 24 times
Summary
This study looked at heart and lung function in 106 people with ME/CFS to better understand post-exertional malaise (PEM) — the severe fatigue and symptom flare after physical activity. Participants did two days of maximal exercise tests, and those with low blood volume on day one received either a saline infusion or a sham infusion before the second test. The goal was to see how blood volume and exercise capacity relate to PEM, not to test a treatment.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
saline infusion
What this could lead to
If successful, this could help explain why ME/CFS patients feel worse after exertion and point toward ways to manage that symptom.
What could go wrong
This is a small, completed observational study, not a treatment trial. Results may not lead to any new therapy or apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.