Icahn School Of Medicine At Mount Sinai

This study tests a new coil device (Kaneka i-ED) in 50 people with wide-necked brain aneurysms. The coil is placed inside the aneurysm to block blood flow and prevent rupture. Researchers will check how well it works, how safe it is, and whether it saves money compared to standar…

This study is for people with advanced HPV-positive throat cancer. It tests whether giving a lower dose of chemotherapy and radiation after an initial round of chemo can still control the cancer while causing fewer side effects. The goal is to find a treatment that is both effect…

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. Instead of operating from the abdomen, surgeons work from the anus upward, which may make it easier to remove the tumor completely. The trial includes 100 adults with e…

This early-phase trial tests whether injecting a long-acting nerve block (using dehydrated alcohol and lidocaine) around the prostate during a biopsy can slow cancer growth in 12 men with high-risk localized prostate cancer. The main goal is to check safety and find the best dose…

This study compares a lower dose of radiation to the standard dose for people with HPV-positive throat cancer. The goal is to see if the lower dose can control the cancer just as well while causing fewer side effects. The trial involves 23 participants with advanced but non-sprea…

This early-phase study tests a new three-drug combination (iberdomide, elotuzumab, and dexamethasone) in adults with multiple myeloma that has returned or stopped responding to prior therapies. The goal is to find the safest dose and see if the combination can shrink tumors. Abou…

This study compares a new contrast agent called gadopiclenol to the standard agent gadoxetate for liver MRI scans. Researchers want to see if gadopiclenol is as good or better at detecting liver lesions. The study involves 23 adults with chronic liver disease or known liver lesio…

This study aims to see if a special MRI scan can accurately detect liver scarring (fibrosis) in people with a liver condition called MASH. Researchers will compare the MRI results with standard tests like ultrasound and blood work in 50 adults. If successful, this could offer a n…

This study tests a new, high-resolution camera that takes 3D pictures of the back of the eye. It aims to see tiny details in the retina of people with age-related macular degeneration (AMD). The goal is to help doctors diagnose AMD earlier and track the disease better. About 50 a…

This study compares a shortened MRI scan to the standard ultrasound for detecting liver cancer in 820 adults with liver cirrhosis. Researchers will also check if blood markers can help spot cancer early. The goal is to see if the faster MRI is more accurate and cost-effective for…

This study tests a digital toolkit called eNav to help more people get screened for colorectal cancer. The toolkit includes a website with information and support, plus text message reminders and instructions. About 400 patients from health centers will use the toolkit to see if …

This study tests whether real-time brain imaging (fMRI) can help people with major depressive disorder learn to reduce rumination—repetitive negative thinking. Participants will receive either real or sham neurofeedback while in an MRI scanner, aiming to strengthen a specific bra…

This early-phase trial is testing the safety of an oral herbal formula called E-B-FAHF-2 in 7 adults with mild-to-moderate Crohn's disease. The formula is a concentrated version of a traditional Chinese medicine blend originally developed for food allergies. Researchers want to s…

This study explores whether adding guided meditation through a virtual reality headset at the start of voice therapy sessions can help people with voice disorders learn and retain treatment better. Sixty participants will use the TRIPP app on a Meta Quest 2 headset to meditate be…

This study tests a device called MIRA that plays calming audio and visual scenes for patients in the neurosciences ICU. The goal is to see if it is safe, practical, and helpful for their mental and physical recovery. The trial includes 20 patients and 15 staff members, and will m…

This study tests whether a team of doctors, nurses, social workers, and community health workers providing palliative care at home can improve symptom control and reduce hospital visits for people with advanced dementia. About 153 patients and their family caregivers are taking p…

This study tests a program called SaMBA-WTC that helps World Trade Center responders with asthma manage their condition better. About 56 adults with uncontrolled asthma will receive either the program or standard attention. The goal is to see if the program improves asthma contro…

This study tests a care model called TIER-PC for people with advanced heart failure or certain cancers. It adjusts the level of care—from a community health worker to a full team including a doctor—based on how severe symptoms are. The goal is to give the right support at the rig…

This pilot study tested whether a nasal spray containing oxytocin, sometimes called the 'love hormone,' could improve trust and cooperation in people with borderline personality disorder (BPD). Forty participants (some with BPD, some healthy) played a trust game after receiving e…

This early-phase study tests whether a single dose of methylphenidate (a drug used for ADHD) can help weaken memories linked to cocaine use. 51 adults with cocaine use disorder will receive either the drug or a placebo before recalling drug-related cues, while their brain activit…

This study tests a program called NeuroResource Facilitation for people with brain injury who are about to leave prison. The goal is to see if extra support helps them avoid getting arrested or sent back to prison. Over 1,000 adults with brain injury and thinking problems took pa…

This observational study aims to better understand asthma by analyzing real-world data and genetic information from over 1,000 adults. Researchers will look at how different asthma subtypes respond to various treatments, including standard therapies and biologics. The goal is to …

This study looks at over 2,000 World Trade Center workers and volunteers to understand lung problems like chronic airway disease and lung cancer. Researchers will review chest CT scans and lung function tests to find patterns and risk factors. The goal is to improve how we track …

This study follows 150 adults aged 65 and older who are receiving radiation therapy for cancer. Researchers track how well patients complete treatment, changes in their daily function, and side effects they report. Participants fill out surveys and do physical and thinking tests …

This study looked at whether telling women about calcium buildup in their breast arteries (found during a mammogram) could encourage them to take steps for better heart health. About 5,500 women took part, and a smaller group received extra information about their results. The go…