H. Lee Moffitt Cancer Center And Research Institute

This early-phase study tested a personalized vaccine made from a patient's own immune cells, designed to target a protein called HER-2 found on some aggressive breast cancers. The goal was to see if the vaccine was safe and could train the immune system to prevent the cancer from…

This early-phase study tested whether combining stereotactic radiosurgery (precise radiation) with the immunotherapy drug nivolumab (Opdivo) is safe and can shrink tumors in people with breast cancer that has spread to the brain. Fourteen participants received the combination. Th…

This study tested a new treatment for people with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) who had not responded to standard therapy. The treatment involved giving patients chemotherapy followed by an infusion of donor immune cells that had been sp…

This pilot study tested a 4-month program that combines weight loss strategies with stress management techniques for Black breast cancer survivors who have obesity and high stress. The program is based on the Diabetes Prevention Program and includes 16 sessions. Researchers measu…

This completed study tested a smartphone-based program to help 520 low-income smokers quit. Participants received nicotine patches and lozenges, plus automated app content and phone counseling. The goal was to see if this approach could boost quit rates in a hard-to-reach populat…

This study tested a new way to deliver chemotherapy directly to the tumor in adults with malignant pleural mesothelioma that cannot be removed by surgery. The treatment, called transarterial chemoperfusion, uses a combination of three drugs (cisplatin, methotrexate, and gemcitabi…

This study tested a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and CNL). The goal was to see if the drug could shrink the spleen and improve blood counts. While not a cure, the treatment aims to control the disease and reduce symptoms.

This early-phase study tested a new treatment called PRGN-3007 UltraCAR-T cells in 3 adults with advanced blood cancers (like leukemia and lymphoma) or triple-negative breast cancer. The goal was to find a safe dose and see if the therapy can shrink tumors. The study is now compl…

This study tested a stem cell transplant from half-matched (haploidentical) family donors for 34 adults with various blood cancers. Patients received a milder chemotherapy and radiation regimen before the transplant. The goal was to see how many patients remained cancer-free 18 m…

This study tested whether adding pacritinib to standard immune-suppressing drugs (sirolimus and tacrolimus) could prevent graft-versus-host disease (GVHD) in 40 patients receiving stem cell transplants for blood cancers. GVHD occurs when donor immune cells attack the recipient's …

This phase 2 trial tested a combination of the targeted drug vemurafenib, special immune cells grown from the patient's own tumor (TIL), and high-dose IL-2 in 17 people with advanced melanoma that had spread. The goal was to see if this approach could shrink tumors and improve su…

This phase 2 trial tested a combination of two drugs—pembrolizumab (Keytruda) and lenvatinib (Lenvima)—in 20 people with advanced neuroendocrine tumors that had worsened despite prior treatments. The goal was to see if the combination could shrink tumors or slow disease progressi…

This early-phase study tested a new treatment called TBio-4101 for people with advanced melanoma that has not responded to standard therapies. The treatment uses a patient's own immune cells (TILs) that are collected from their tumor, multiplied in a lab, and then given back afte…

This early-stage study tested whether combining a procedure that uses electrical pulses to destroy tumors (IRE) with an immunotherapy drug (pembrolizumab) is safe for people with locally advanced pancreatic cancer that cannot be removed by surgery. Only 2 participants were enroll…

This study tested a combination of two chemotherapy drugs, nab-paclitaxel and gemcitabine, in 59 teenagers and young adults whose sarcoma (a type of bone or soft tissue cancer) had returned or not responded to standard treatment. The main goals were to see if the drug combo could…

This study tested a combination of two drugs (ofatumumab and lenalidomide) plus a steroid (methylprednisolone) in 45 people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal was to see if the treatment could make all signs of cancer disappear for…

This early-phase study tested a combination of two drugs, trametinib and ceritinib, in 27 people with advanced melanoma that had stopped responding to standard treatments. The main goal was to find the safest dose and see if the combination could shrink tumors. While not a cure, …

This study tested a combination of two drugs, TAS 102 and ramucirumab, in 23 people with advanced stomach or gastroesophageal junction cancer that had not responded to prior treatments. The goal was to see if the combo was safe and could help patients live longer. Results focus o…

This study tested the drug nivolumab in 54 people with advanced biliary tract cancer (cancer of the bile ducts or gallbladder) that had not responded to prior chemotherapy. The goal was to see if nivolumab could shrink tumors or slow the cancer's growth. Nivolumab is an immunothe…

This early-stage study tested whether adding a drug called BMS-986004 to standard immune-suppressing medicine could help prevent acute graft-versus-host disease (GVHD) in 45 adults with blood cancers or disorders receiving a stem cell transplant. GVHD occurs when donor immune cel…

This study tested whether injecting a modified herpes virus (T-VEC) directly into tumors, alongside standard chemotherapy before surgery, could better eliminate triple negative breast cancer. The virus is designed to infect and destroy cancer cells while leaving healthy cells alo…

This study tested a treatment for advanced melanoma that uses a patient's own immune cells. 19 participants had their tumor-fighting cells (TILs) removed, grown in a lab, and then given back along with high-dose IL-2 after chemotherapy. The main goal was to see if this approach w…

This study tested a combination of two immunotherapy drugs—high-dose interleukin-2 (IL-2) and pembrolizumab (Keytruda)—in 27 adults with metastatic kidney cancer. The goal was to see if the combination could shrink or eliminate tumors. Participants received both drugs in a coordi…

This early-phase study tested a combination of two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to other treatments. The goal was to find the safest dose and see if the combination could help control the cancer. The st…

This early-phase study tested a vaccine made from patients' own immune cells to target HER2-positive breast cancer. 31 participants with stage II or III breast cancer received the vaccine alongside standard chemotherapy before surgery. The goal was to see if the vaccine could boo…

This early-phase study tested a combination of two drugs—capecitabine (a chemotherapy pill) and cemiplimab (an immunotherapy)—in 13 people with hormone receptor-positive breast cancer that had spread. The main goal was to find the safest dose and see if the combo could shrink tum…

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This early-phase trial tested a treatment that uses a patient's own immune cells (called TILs) to fight soft tissue sarcoma. Nine young adults received chemotherapy to prepare their bodies, then an infusion of their own TILs plus high-dose IL-2 to boost the immune response. The m…

This study tested a new drug called AZD1775 combined with standard chemotherapy (carboplatin and paclitaxel) in 42 people with advanced squamous cell lung cancer. The goal was to see if the combination could slow cancer growth or improve survival. Researchers measured how long pa…

This study tested whether using a negative pressure wound therapy device (a special vacuum bandage) for a longer time after surgery could lower the chance of wound infections in people with gastrointestinal cancer. About 290 patients took part. The goal was to see if this approac…

This study tested whether combining two FDA-approved drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that has returned or spread. A total of 95 participants received the drug combination to find the safest dose and see if it improved survival.…

This early-phase study tested a combination of the immunotherapy drug avelumab and whole brain radiotherapy in 16 adults with leptomeningeal disease, a rare condition where cancer spreads to the lining of the brain and spinal cord. The main goal was to find a safe dose and identi…

This pilot study tested a new combination treatment for people with advanced melanoma that has spread. It combined a patient's own immune cells grown in a lab (called TILs) with an immunotherapy drug called ipilimumab. The main goals were to see if the treatment was safe and poss…

This early-phase trial tested a combination of two drugs, IRX-2 and durvalumab, in 19 people with advanced head and neck cancer that could not be cured with standard treatments. The goal was to see if the combination was safe and could boost the immune system's attack on tumors. …

This study tested a new approach for people with advanced melanoma that can be surgically removed. Participants received a combination of two immunotherapies: one injected directly into the tumor (Tavo) and one given through a vein (nivolumab). After 12 weeks, they had surgery to…

This early-phase study tested a combination of two drugs—CG0070 (given directly into the bladder) and nivolumab (given through a vein)—in 21 people with muscle-invasive bladder cancer who were not eligible for the standard chemotherapy drug cisplatin. The main goal was to check s…

This early-phase study tested adding the drug pirfenidone to standard chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe dose and see if the combination could shrink tumors. 48 participants were enrolled, and the study is now comp…

This early study tested whether giving a single dose of nivolumab with either ipilimumab or relatlimab before surgery is safe and possible for people with melanoma that has spread to the brain. Only one person took part, so results are very limited. The goal was to see how the dr…

This early-phase study tested a new drug combination (duvelisib plus BMS-986345) in 14 people with blood cancers like lymphoma, myeloma, and leukemia. The main goal was to find a safe dose and check for side effects. Researchers also looked at how well the cancer responded after …

This study looked at whether giving people personalized information about their genetic risk for melanoma could encourage them to protect themselves from the sun. Over 2,000 adults received either standard sun safety tips or tailored advice based on their DNA. Researchers then tr…

This study tested a 12-week digital health coaching program for people with pancreatic cancer and their caregivers. The goal was to see if the program was easy to use and helpful. 20 participants from Moffitt Cancer Center took part in the pilot study.

This study looked at whether eating only during an 8-10 hour daytime window (without cutting calories) could help immunotherapy work better in people with advanced head and neck cancer. 29 patients were asked to follow this eating pattern, and researchers tracked how well they st…

This study tested a 12-week program that gave nutrition counseling and a Fitbit app to 10 people with gastrointestinal cancer who had surgery and chemotherapy. The goal was to see if the program was easy to use and if patients liked it. Researchers measured how many people joined…

This study tested a mobile health (mHealth) program designed to help people who have had a stem cell transplant for blood cancer get better sleep. Researchers wanted to see if the program was easy to use and if participants liked it. About 30 survivors, caregivers, and doctors ga…

This study tested a program that provides nutrition and supportive care remotely to adults with pancreatic cancer who are receiving chemotherapy. The goal was to see if the program was easy to use and if patients were satisfied with it. 50 participants were enrolled to track how …

This study tested a new smartphone app that uses mindfulness exercises to help cancer survivors quit smoking. Twelve participants used the app and attended counseling sessions, then rated how much they liked the app and how helpful it was. The goal was to see if the app was easy …

This study tested whether a remote resistance training program is feasible and safe for people with advanced upper gastrointestinal cancer who are on chemotherapy. Twenty-two participants were asked to do strength exercises at home using video guidance. The study measured how man…

This study tested a smartphone app that uses augmented reality to help reduce cravings to smoke. 14 adults who recently quit smoking tried the app and rated how easy it was to use and how much they liked it. The goal was to see if the app could be a helpful tool for quitting smok…

This study tested whether a pickleball program is practical and enjoyable for cancer survivors and their family or friends. The goal was to increase physical activity and improve overall wellness. 28 participants joined the program, which involved learning and playing pickleball …

This study tested whether a special online tool (eSNAP) plus a personal helper (Caregiver Navigator) could make family caregivers of brain cancer patients feel less stressed and burdened. About 296 caregivers and patients took part. The goal was to improve well-being by measuring…

This study tested a program to help lung cancer patients stop smoking and avoid starting again. 21 adults with lung cancer who smoked took part. The program included counseling, a web video, and support calls. The goal was to see if the program was easy to use and if patients lik…

This study tested a new mindfulness-based program to help people reduce alcohol use and quit smoking. 67 adults who smoked and drank alcohol participated. The goal was to see if the program was practical and liked by participants, and to measure how many quit smoking by the end o…

This study looked at whether using a person's DNA to pick an antidepressant works better than usual care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Half got a DNA-guided choice of medication, and the other half got standard care. Resear…

This completed study created a biobank of questionnaires, saliva, and tumor tissue from 592 African American men with prostate cancer in Florida. The goal was to collect data and samples to explore whether smoking makes prostate cancer more aggressive. Participants completed surv…

This completed study involved 100 men aged 40 and older, with no personal history of prostate cancer, to understand their beliefs about genetic risk and their willingness to provide a saliva sample for genetic testing. Researchers used questionnaires and saliva samples to assess …

This study tested whether a community education program could improve people's understanding of clinical trials. Researchers provided culturally tailored presentations to 85 English- or Spanish-speaking adults in the Tampa Bay area. Participants completed surveys before and after…

This study followed 60 adults with diffuse large B-cell lymphoma or transformed lymphoma who received commercial axi-cel therapy. Researchers measured changes in memory, attention, executive function, hand strength, and quality of life using surveys and cognitive tests. The goal …

This study looked at how two different diets affect the gut bacteria of healthy Black and White adults in Alabama. For 28 days, participants ate either the DASH diet (rich in fruits, vegetables, and low-fat dairy) or a standard American diet. Researchers collected stool samples t…

This study looked at whether an exercise program is practical for people aged 65 and older with blood cancers like lymphoma, leukemia, or myeloma who are about to receive CAR T-cell therapy. The program included remote exercise sessions and was tested with 20 participants to see …

This study tested whether a mathematical model could help doctors choose the best radiation schedule for people with HPV-positive throat cancer. The goal was to see if personalized dosing could shrink tumors faster than standard treatment. Fifty-five adults took part, and researc…

This study tested a smartphone app designed to educate and monitor patients with advanced kidney cancer (stage IV) who are starting combination immunotherapy. Twenty patients used the app, and researchers measured how acceptable and helpful it was, including its effect on quality…

This small study tested whether using a patient's tumor genetics to guide radiation dose could work for stage 2-3 non-small cell lung cancer. Only 3 people took part, and the main goal was to see if the approach was safe and feasible. The study is complete, but results are not ye…

This study tested a new device called the EnVisio SmartClip that helps doctors mark and find breast tumors during surgery. 50 people with breast cancer took part. The goal was to see if the SmartClip makes it easier for surgeons to locate and remove the right tissue.

This study gave educational materials about colorectal cancer and screening to 188 adults aged 45-75 in the Tampa Bay area. Researchers used surveys to measure changes in knowledge and screening intentions. The goal was to see if education encourages people to talk to their docto…

This study looked at 30 people with a rare and aggressive type of gut cancer called poorly-differentiated neuroendocrine carcinoma. Researchers used a special PET scan to see if the cancer cells have a certain marker (somatostatin receptor) that could be targeted by a future trea…