H. Lee Moffitt Cancer Center And Research Institute

This study looks at ways to increase HPV vaccination rates among 11-17 year olds in 8 community health centers in Florida. Researchers will use strategies that involve parents, healthcare providers, and the clinics themselves to encourage more teens to start and complete the HPV …

This study tests whether adding stress management to a standard weight loss program helps Black women with obesity lose more weight. About 341 women with high stress levels will take part. The program includes 26 sessions focused on diet, exercise, and coping with stress.

This study looks at whether giving a pneumonia vaccine (PCV13) before and after CAR T-cell therapy can improve the immune system's ability to fight pneumococcus bacteria in people with certain types of lymphoma. About 26 participants with relapsed or hard-to-treat B-cell lymphoma…

This early-phase study tests an experimental drug (XL888) added to two standard targeted therapies for people with advanced BRAF-mutated melanoma that cannot be removed by surgery. The main goal is to find the safest dose of XL888 and check for side effects. About 26 adults with …

This early-phase trial tests whether infusing specially grown donor immune cells (γδ T-cells) can help prevent acute myeloid leukemia from coming back after a stem cell transplant. About 20 adults at high risk of relapse will receive a single infusion of these cells. The main goa…

This early-stage study tests whether giving the drug cemiplimab before surgery is safe for people with Merkel cell carcinoma or cutaneous squamous cell carcinoma. About 36 participants will receive the drug and then have their tumors removed. Researchers will track side effects a…

This study tests whether adding the immunotherapy drug nivolumab to standard radiation and hormone therapy is safe and helps delay the progression of a very aggressive type of prostate cancer (Gleason Group 5). About 44 men who have not yet received treatment for their prostate c…

This early-stage study tests whether adding canakinumab to a standard anemia drug (darbepoetin alfa) can help people with lower-risk myelodysplastic syndromes (MDS) who no longer respond to standard treatment. The goal is to reduce or eliminate the need for blood transfusions. Ab…

This early study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced melanoma that has a BRAF mutation. The goal was to see if an on/off schedule could help control the cancer. 14 adults with stage IIIC to IV melanoma took part…

This study tests whether combining phototherapy (light treatment) with the drug mogamulizumab can help control early-stage mycosis fungoides, a type of skin lymphoma. About 20 adults will receive both treatments together. The main goal is to see how many patients' skin symptoms i…

This early-phase study tests a combination of two drugs—romidepsin and durvalumab—given directly into the bladder for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. The main goal is to find the safest dose and see if the treatment can shrink …

This study tests whether the immunotherapy drug nivolumab, alone or with azacitidine, is safe and effective for people whose osteosarcoma (a type of bone cancer) has come back and can be surgically removed. About 21 participants will receive the treatment before and after surgery…

This study tests a new way of giving hormone therapy for stage IV prostate cancer that still responds to hormone treatment. Instead of a fixed dose, the treatment is adjusted based on how the cancer responds, aiming to keep the disease under control while reducing side effects. T…

This study tests a new way to treat high-risk prostate cancer that has spread. The approach uses two steps: first, hormone therapy to block cancer growth, followed by chemotherapy to attack remaining cancer cells. The goal is to see if this sequence helps patients live longer. Th…

This study tests a vaccine made from a patient's own immune cells, designed to target HER2-positive breast cancer. About 31 people with stage II or III breast cancer will receive the vaccine alongside standard chemotherapy before surgery. The goal is to see if the vaccine can str…

This study tests whether adding a drug called sacituzumab govitecan to two immunotherapy drugs (ipilimumab and nivolumab) can shrink tumors in people with advanced bladder cancer who cannot take standard chemotherapy. About 46 adults will take part. The goal is to find the safest…

This early-phase study tested whether taking the drug abiraterone on an on-and-off schedule could help men with advanced prostate cancer respond to the drug for a longer time. The study enrolled 19 men whose cancer had stopped responding to standard hormone therapy. Researchers m…

This study tests whether giving hormone therapy and chemotherapy in an adaptive, on-and-off pattern can keep prostate cancer sensitive to hormone treatment longer. It involves 25 men with stage IV prostate cancer that still responds to hormones. The goal is to see if this approac…

This study tests whether giving focused radiation before surgery for brain metastases can delay tumor regrowth compared to standard care. About 49 adults with solid tumors and brain lesions will receive pre-operative stereotactic radiosurgery followed by surgery. The goal is to i…

This early-phase study tests a new treatment for people with advanced head and neck cancer that has spread or come back. The treatment uses a patient's own immune cells (called TILs) that are grown in a lab and given back along with an immunotherapy drug (pembrolizumab). The main…

This study compares an automated video-based smoking cessation program to standard treatment for people living with HIV. Researchers want to see if the automated approach helps more participants quit smoking for good. The study enrolled 638 HIV-positive adults who smoke at least …

This study tests whether adding targeted radiation (SBRT) to an immunotherapy drug (atezolizumab) can shrink tumors better than the drug alone in people with cervical cancer that has come back or spread. About 21 adults with advanced cervical, vaginal, or vulvar cancer are partic…

This study looks at whether a combination of two drugs works better than one drug alone to keep multiple myeloma from coming back after a stem cell transplant. About 69 adults with newly diagnosed myeloma will receive either a single drug or a two-drug combo as maintenance therap…

This study tests a new approach to help people who have had cervical cancer or high-grade cervical dysplasia quit smoking. Participants receive phone counseling and personalized text messages to support quitting. The goal is to see if this method helps more people stay smoke-free…

This study tests a new way of giving two approved drugs (pembrolizumab and axitinib) to people with advanced kidney cancer. Instead of a fixed schedule, the dose and timing are adjusted based on how well the tumor responds. The goal is to keep the cancer under control while possi…

This study tests whether adding ruxolitinib to a standard tyrosine kinase inhibitor (TKI) can help people with chronic myeloid leukemia (CML) achieve a lasting remission after stopping all treatment. Participants are adults with CML who previously tried to stop their TKI but rela…

This study tests a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and chronic neutrophilic leukemia). The goal is to see if the drug can shrink the spleen and improve blood counts. Fedratinib is taken as a pill and aims to control the disease, not cure it.

This early-phase study tests whether 30 minutes of moderate exercise (like arm cycling or treadmill) right before each immunotherapy session can improve treatment for skin cancers such as melanoma. About 22 adults who are starting standard immunotherapy will participate. The main…

This study tests whether a natural substance called delta-tocotrienol (a form of vitamin E) can prevent pancreatic cysts (IPMN) from growing or turning into cancer. About 4 adults with low-risk IPMN are randomly assigned to receive either the supplement or a placebo. The goal is …

This study tests whether a practical diet and exercise program can help people with certain pancreatic cysts (IPMNs) lower their risk of developing pancreatic cancer. Twenty-four adults with large cysts and excess belly fat will follow a 6-month program of physical activity and n…

This study tests two different vaccines in people who have already been treated for HER-2 positive breast cancer but still had some cancer left after chemotherapy and surgery. The goal is to see if the vaccines are safe and can help prevent the cancer from coming back. About 119 …

This study tests a procedure called prostatic artery embolization (PAE) in 17 men with early-stage prostate cancer who also have trouble urinating. The goal is to see if PAE can safely reduce urinary symptoms before they start radiation therapy. Participants will have their sympt…

This study tests a program that gives pancreatic cancer patients extra nutrition support from dietitians through remote visits and a Fitbit to track eating. The goal is to see if the program is practical and liked by patients, and to help prevent weight loss and malnutrition duri…

This study looks at whether an exercise program before surgery is practical and safe for people aged 65 and older with liver or bile duct cancer. About 25 participants will try a home-based exercise routine to see if they can stick with it and if it helps their physical function …

This study looks at how the DASH diet (a heart-healthy eating plan) changes gut bacteria compared to a typical American diet. About 115 Black and White adults in Alabama will eat provided meals for 28 days. Researchers will test stool samples to see if the DASH diet increases hel…

This study examines how much microplastic pollution is present in the lungs of 119 people undergoing a lung wash procedure. Researchers will compare levels between those with and without lung cancer to see if there is a connection. The goal is to better understand if microplastic…

This study tests a program called CARES-REACH to help more people in rural clinics get screened for colorectal cancer. Researchers will track how many patients complete a simple stool test (FIT) and look at factors like income and language that affect screening rates. The goal is…

This study is testing whether a special diet and exercise program is practical and helpful for people who have had head and neck cancers (like mouth or throat cancer). About 40 adults who are scheduled for radiation treatment will take part. The main goal is to see if people can …

This study looks at the lifestyle habits and quality of life of people who had cancer as young adults (ages 19–29) and are now at least one year past treatment. Researchers will use surveys, Fitbit data, and interviews to understand current behaviors and needs. The goal is to cre…

This study is testing a new online education tool called REFLECT. It is designed to help young adults (ages 18-39) who have had cancer better understand their fertility options and the genetic risks for their future children. The study involves 16 participants and focuses on how …

This study looks at whether a different breathing machine setting (APRV) can help lungs work better during robotic surgery for gynecologic or genitourinary cancers, compared to the usual method (CMV). About 12 adults will be enrolled to find the best settings for lung function. T…

This study looks at 500 men with prostate cancer to find non-invasive biomarkers—like substances in blood or urine—that can show if the disease is getting worse. Participants continue their normal care, including biopsies and scans, and also give extra blood and urine samples. Th…