H. Lee Moffitt Cancer Center And Research Institute

This early-stage trial tests a new dendritic cell vaccine for people with breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). The vaccine is designed to train the immune system to attack cancer cells. The main goal is to find the saf…

This early-phase trial tests an adaptive approach to hormone therapy for men with stage IV prostate cancer that still responds to hormone treatment. Instead of a fixed schedule, the treatment is adjusted based on PSA levels. The study includes 17 participants and combines standar…

This early-phase trial tests whether using MRI scans to guide radiation therapy can improve outcomes for people with locally advanced rectal cancer. Twenty participants receive chemotherapy (capecitabine and FOLFOX) along with radiation doses that are adjusted based on MRI images…

This phase 2 trial tests whether a combination of curcumin (from turmeric) and fish oil can reduce the size of lung nodules in former and current smokers aged 55 and older. Nineteen participants took the supplements or a placebo for 6 months. The study aims to see if the nodules …

This study tests whether eating 3-6 servings of fermented foods daily (like yogurt, kefir, and sauerkraut) can improve how well cancer treatments work in patients with locally advanced rectal cancer or non-small cell lung cancer. The 39 participants are randomly assigned to eithe…

This study is testing whether a combination of three drugs—nivolumab, ipilimumab, and nintedanib—can safely shrink tumors in people with advanced non-small cell lung cancer that has no curative options. The trial involves 66 participants and is split into two phases: the first fi…

This phase II trial tests two drugs—olaparib and pembrolizumab—together in 12 people with advanced uveal melanoma, a rare eye cancer that has spread. The goal is to see if the combination can shrink tumors or slow the disease. The study is active but no longer recruiting, and res…

This early-phase study tests the safety of giving specially grown immune cells (T cells) to people with metastatic HER2-positive breast cancer. Participants first receive a vaccine made from their own immune cells plus two drugs (pepinemab and trastuzumab) to help the body fight …

This study tests whether adding focused radiation to a two-drug immunotherapy combination works better than the drugs alone for people with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. About 50 adults with cancer that has spread or cannot be removed will rec…

This study tests whether a daily dose of green tea catechins (a natural compound) can prevent low- to intermediate-risk prostate cancer from getting worse in men who are not receiving immediate treatment. Over 24 months, 115 men will receive either the green tea extract or a plac…

This study tests a new approach for men with stage IV prostate cancer that still responds to hormone therapy. Instead of continuous hormone treatment, doctors adjust the timing based on PSA levels and add chemotherapy. The goal is to see if this strategy can keep the cancer sensi…

This study tests whether combining two drugs, binimetinib and belinostat, can shrink or stop the growth of metastatic uveal melanoma, a rare eye cancer that has spread. About 7 adults with this condition are taking part. The main goal is to see how many patients respond to the tr…

This study tests a combination of two drugs, lenvatinib and pembrolizumab, given before surgery to people with a rare skin cancer called Merkel cell carcinoma. The goal is to see if the drugs can shrink or eliminate the tumor before it is removed. The trial involves 26 adults wit…

This early-phase trial tests whether infusing specially grown donor immune cells (gamma delta T-cells) can prevent acute myeloid leukemia from returning in patients who are at high risk of relapse after a stem cell transplant. About 20 adults aged 18–75 will receive a single infu…

This phase II trial tests whether adjusting doses of two drugs—pembrolizumab (Keytruda) and axitinib (Inlyta)—based on tumor response can better control advanced kidney cancer. The study aims to enroll 75 adults with clear cell renal cell carcinoma that has spread. The trial is c…

This early-phase trial tests a new drug called XL888 added to two standard melanoma drugs (vemurafenib and cobimetinib) for people with advanced BRAF-mutated melanoma that cannot be removed by surgery. The main goal is to find the safest dose of XL888 and see how well the combina…

This phase 2 study tests whether adding ruxolitinib to standard tyrosine kinase inhibitor (TKI) therapy can help people with chronic myeloid leukemia (CML) stop their medication and stay in remission. The 24 participants had already tried stopping TKI once but relapsed. They will…

This study tested whether adding stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 women with high stress levels took part. The goal was to see if a culturally-tailored approach could improve weight loss resul…

This study tested the drug ruxolitinib in 29 adults with chronic myelomonocytic leukemia (CMML), a rare blood cancer. The goal was to see if the drug could improve blood counts, shrink the cancer, or keep it stable. Researchers also tracked how long patients lived and whether the…

This study looks at whether giving a pneumonia vaccine (PCV13) before and after CAR T-cell therapy helps lymphoma patients build stronger immunity. About 26 adults with certain types of B-cell lymphoma will receive the vaccine around their CAR T treatment. The goal is to see if t…

This study tests if giving focused radiation before surgery for brain metastases can delay tumor regrowth compared to standard care. About 49 adults with solid tumors that have spread to the brain will receive pre-operative stereotactic radiosurgery followed by surgery. The goal …

This study compares an automated video-based smoking cessation program to standard treatment for people living with HIV. The goal is to see if the automated approach leads to more long-term quit rates. 638 participants who smoke at least 5 cigarettes daily and are willing to quit…

This study tests whether a program combining phone counseling and personalized text messages can help 360 cervical cancer survivors in Florida quit smoking better than standard quitline services. Participants must have a history of cervical cancer or high-grade cervical dysplasia…

This early-phase study tests a combination of two drugs—romidepsin and durvalumab—given directly into the bladder for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. The goal is to see if the combination is safe and can shrink or eliminate tum…

This study tests a drug called DFMO combined with the immunotherapy pembrolizumab in people with advanced non-small cell lung cancer (NSCLC). The goal is to find a safe dose and see if the combination helps shrink tumors. About 45 adults with measurable disease will take part.

This early-stage trial tests two drugs together—canakinumab and darbepoetin alfa—in people with a lower-risk form of myelodysplastic syndromes (MDS) whose previous treatment stopped working. The goal is to see if the combination is safe and can help the body make more red blood c…

This study tests a combination of three drugs (ipilimumab, nivolumab, and sacituzumab govitecan) as a first treatment for people with advanced bladder cancer who cannot take standard chemotherapy. About 46 adults will participate to find the best dose and see how well the drugs s…

This study tests whether combining two drugs, pembrolizumab and vorinostat, can help control advanced non-small cell lung cancer. About 120 adults with stage IV lung cancer will receive either the combination or pembrolizumab alone. The goal is to see if the combination is safe a…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

This study tests a combination of the experimental drug neratinib plus standard chemotherapy, trastuzumab, and pembrolizumab in people with HER2-positive gastroesophageal cancer. The goal is to see how well the treatment shrinks tumors and controls the disease. About 8 adults wit…

This study tests whether giving two drugs (cetuximab and cemiplimab) before surgery can help shrink tumors in people with head and neck squamous cell carcinoma. About 22 adults will receive the combination before their planned surgery. The main goal is to see how many patients ha…

This early-stage trial tests a new way to treat high-grade bladder cancer that hasn't spread into the muscle. Doctors take immune cells from the patient's own tumor, grow them in a lab, and put them back into the bladder. The goal is to see if this is safe and can shrink or elimi…

This early-phase study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced BRAF-mutant melanoma. Instead of taking the drugs every day, participants followed an on/off schedule to see if it could control the cancer while reduci…

This study tests a drug called luspatercept in 6 adults with lower-risk myelodysplastic syndromes (MDS) or related blood cancers who have anemia. The goal is to see if the drug can reduce or eliminate the need for regular blood transfusions. Participants receive luspatercept plus…

This early-phase study tests a combination of two drugs, ceritinib and docetaxel, in people with advanced non-small cell lung cancer that does not have certain genetic markers (ALK-negative, EGFR wild-type). The main goal is to find the safest dose and see if the combination can …

This early-phase study tests whether 30 minutes of moderate exercise (like walking or cycling) right before standard immunotherapy can improve treatment for certain skin cancers (melanoma, squamous cell carcinoma, Merkel cell carcinoma). About 22 adults will exercise before each …

This study tests whether adding targeted radiation (SBRT) to the immunotherapy drug atezolizumab can shrink tumors better than atezolizumab alone in people with cervical cancer that has come back or spread. About 21 adults with advanced cervical cancer are participating. The goal…

This study tests whether radiation therapy followed by two targeted drugs (trastuzumab and pertuzumab) given directly into the spinal fluid is safe and helps people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord live longer. About 33 adults wi…

This early-phase trial tests whether adding chest radiation followed by immunotherapy drugs (durvalumab alone or with tremelimumab or olaparib) can help control extensive-stage small cell lung cancer after initial chemotherapy. About 25 adults whose cancer did not worsen after fi…

This study tests four different chemotherapy schedules in children and adults with a rare, aggressive muscle cancer that has spread. Participants choose from a first-strike approach, a first-strike followed by maintenance, an adaptive schedule, or standard chemo. The goal is to s…

This pilot study aimed to see if combining phototherapy (light treatment) with the drug POTELIGEO (mogamulizumab) is safe and effective for people with early-stage mycosis fungoides, a type of skin lymphoma. The study planned to enroll 20 adults with stage IA-IIA disease. However…

This study tests whether adding the immunotherapy drug nivolumab to standard radiation and hormone therapy is safe and effective for men with a very aggressive type of prostate cancer (Gleason grade group 5). About 44 men will receive the combination treatment. The goal is to see…

This early-phase study tests a new treatment for people with advanced head and neck cancer that has spread or come back. The treatment uses a patient's own immune cells (called TILs) that are grown in a lab and given back along with the drug pembrolizumab, with or without chemoth…

This study tests a personalized treatment plan using the drug daratumumab for adults aged 65 and older who have newly diagnosed multiple myeloma and cannot tolerate standard high-dose chemotherapy. The goal is to see how well the treatment controls the disease by measuring tumor …

This study tests a two-step treatment plan for men with high-risk metastatic prostate cancer. First, patients receive hormone therapy plus a newer drug, followed by chemotherapy. The goal is to improve survival by attacking the cancer in a sequence inspired by how species go exti…

This early-phase study tests a virus-based drug called CG0070 in 20 people with intermediate-risk bladder cancer that has not invaded the muscle. After surgery to remove visible tumors, patients receive CG0070 to see if it is safe and can help prevent the cancer from coming back.…

This study is for people whose osteosarcoma (a type of bone cancer) has come back and can be surgically removed. It tests two drugs: nivolumab (an immunotherapy) alone or with azacitidine (a chemotherapy-like drug). The goal is to see if these treatments are safe and can keep the…

This study tests a health workshop for Latino parents of children aged 6 to 12 living in rural Florida. The workshop teaches healthy eating, physical activity, and sun protection to help reduce cancer risk. Researchers will check if families find the program useful and if it help…

This study looks at whether training healthcare providers and giving parents easy-to-understand information can increase HPV vaccination rates among 11-17 year olds. It involves 564 participants across 8 community health centers in Florida. The goal is to help prevent HPV-related…

This study tests whether a natural compound called delta-tocotrienol (a form of vitamin E) can prevent pancreatic cysts (IPMNs) from growing or turning into cancer. About 4 adults with IPMNs that are being watched but not yet dangerous will receive either the supplement or a plac…

This study tests two different vaccines designed to prevent HER-2 positive breast cancer from coming back in people who have already completed initial treatment. About 119 participants who had surgery after chemotherapy will receive one of the two vaccines, followed by booster sh…

This study tests whether a practical diet and exercise program can help people with certain pancreatic cysts lower their risk of developing pancreatic cancer. Twenty-four adults with a type of pancreatic cyst called IPMN (larger than 15 mm) and who are overweight will follow a 6-…

This study tests a program that provides remote nutrition counseling and uses a Fitbit to track activity and diet for people with gastroesophageal cancer. Participants log their food intake and meet with a dietitian via video calls. The goal is to see if this approach is practica…

This study looks at whether a remote nutrition coaching program is practical and well-liked by people with pancreatic cancer who are getting chemotherapy. About 40 adults with newly diagnosed, treatable but not yet removable pancreatic cancer will take part. The program involves …

This study tests a procedure called prostatic artery embolization (PAE) in 17 men with low-risk prostate cancer who also have trouble urinating. The goal is to see if PAE can reduce urinary symptoms before they start radiation therapy. Participants will have their symptoms and pr…

This study tests a program that gives pancreatic cancer patients extra nutrition support from a dietitian through remote visits. The goal is to see if the program is practical and helpful for patients receiving chemotherapy. About 80 adults with advanced pancreatic cancer will ta…

This study looks at whether a mindfulness-based stress management program can lower the stress and burden felt by caregivers of patients receiving a stem cell transplant (allogeneic HCT). About 505 caregivers and patients are taking part. The program uses a smartphone app to teac…

This study tests a web-based tool called REFLECT, designed to help adolescent and young adult cancer patients learn about fertility and genetic risks for future children. Sixteen participants who received cancer care at Moffitt Cancer Center will use the tool and rate its ease of…

This study looks at 69 people with multiple myeloma who had a stem cell transplant. It compares those who take one maintenance drug versus two drugs (an immunomodulatory agent plus a proteasome inhibitor) afterward. The goal is to see which approach better turns cancer cells unde…

This study looks at whether non-invasive tests—like blood, urine, and genetic analysis—can help track prostate cancer progression without repeated biopsies. Researchers will follow 500 men with low, intermediate, or high-risk prostate cancer as they receive standard care. The goa…

This study tests a 12-week program that gives cancer survivors free fruits and vegetables, recipe cards, and cooking demonstrations. The goal is to see if people will join and stick with the program, not to measure health outcomes. Only 11 participants are enrolled, making this a…

This study aimed to compare a newer breathing machine method (APRV) with the standard method (CMV) during anesthesia for robotic gynecologic or genitourinary cancer surgery. The goal was to find the best settings to help patients' lungs work well during the procedure. However, th…

This study is collecting fluid from the lungs of 119 patients (some with lung cancer, some without) to measure how many microplastic particles are present. Researchers want to see if people with lung cancer have more microplastics in their lungs. The goal is to understand if micr…

This study is creating a biobank—a collection of blood, tissue, and other samples—from 500 people with or suspected of having pancreatic cancer. The goal is to learn why some groups are affected more than others and to find ways to personalize care. Participants donate samples an…

This study looks at the lifestyle habits and quality of life of young adults who had cancer between ages 19 and 29. Researchers will use surveys and fitness trackers to understand current behaviors and then create a personalized diet and exercise program. The goal is to help surv…

This study looks at how quality of life differs among older adults (60+) newly diagnosed with acute myeloid leukemia (AML) who receive either intensive or non-intensive chemotherapy. Researchers aim to build a decision-making model that helps patients and doctors choose treatment…

This study is creating a large database of people at high risk for pancreatic cancer, including those with cysts, genetic conditions, or other risk factors. The goal is to track their health over time to find better ways to detect the disease early or even prevent it. About 317 p…

This study looks at whether a tumor test called Decipher can predict aggressive prostate cancer as accurately in African-American men as in other men. Researchers will follow 240 men with prostate cancer to see if the test helps doctors choose the right treatment. The goal is to …

This study tests whether a personalized diet and exercise program is practical for people who have had head and neck cancers (like mouth or throat cancer). Researchers will enroll 40 survivors to see if they can stick with the program and find it helpful. The goal is to learn if …

This study looks at whether a home-based exercise program is practical and safe for people aged 65 and older who are waiting for liver or bile duct cancer surgery. About 25 participants will do supervised exercise sessions and be tracked for how many join, stick with it, and repo…

This study looks at whether a special program called CARES-REACH can help more people in rural areas get screened for colorectal cancer. The program focuses on using a simple at-home stool test (FIT). Researchers will track how many patients complete the test and see what factors…