H. Lee Moffitt Cancer Center And Research Institute

This early-stage trial tests a personalized vaccine made from a patient's own immune cells and tumor DNA. It is for people with high-risk triple negative breast cancer who still have tumor left after standard chemotherapy and surgery. The goal is to see if the vaccine is safe and…

This study tests whether adding the drug elranatamab after CAR-T cell therapy (cilta-cel) can help people with high-risk relapsed myeloma live longer without their cancer getting worse. About 39 participants who have already received CAR-T will receive elranatamab as maintenance.…

This early-phase trial tests a new treatment for men with advanced prostate cancer that has spread to the bones and stopped responding to standard therapies. The approach takes a patient's own immune cells (gamma delta T cells), genetically modifies them to better recognize and a…

This study tests whether adding venetoclax to standard chemotherapy (CLAG-M) helps people with relapsed or refractory acute myeloid leukemia (AML) achieve deeper remission and live longer without the cancer returning. About 52 adults aged 18–80 will be randomly assigned to receiv…

This early-phase study tests whether the drug asciminib is safe and tolerable for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) after they have received a stem cell transplant or CAR T-cell therapy. The goal is to prevent the cancer from retu…

This study tests whether taking itacitinib pills before CAR-T cell therapy can improve outcomes for people with diffuse large B-cell lymphoma. About 27 adults will receive the combination to see if it helps control the disease longer. The goal is to reduce severe side effects and…

This study looks at whether adults with acute myeloid leukemia (AML) whose cancer is in remission after a year of treatment can stop their chemotherapy (azacitidine or decitabine plus venetoclax) without the leukemia coming back. About 37 participants will be followed for 18 mont…

This study tests whether combining two drugs—olaparib and pembrolizumab—can shrink or control advanced uveal melanoma, a rare eye cancer that has spread. About 37 adults with this condition will receive the treatment. The goal is to see how many patients respond and how long the …

This study is for people with advanced melanoma (stage III or IV) that has a BRAF V600 mutation. Participants first receive a combination of two targeted drugs (encorafenib and binimetinib) before surgery. After surgery, doctors check how much the tumor has responded. Based on th…

This early-phase study tests whether adding aspirin to standard chemotherapy can reduce immune-suppressing cells inside ovarian, fallopian tube, or peritoneal tumors. About 100 women will take aspirin alongside chemo before surgery. The goal is to see if this combination makes th…

This study tests whether using special imaging (radiomics) to find the most aggressive parts of a high-grade sarcoma tumor and giving those areas extra radiation can improve outcomes. About 43 adults with high-grade soft tissue sarcoma will receive this targeted radiation before …

This study tests the safety and effectiveness of combining two drugs, rituximab and zanubrutinib, for people with untreated follicular lymphoma or marginal zone lymphoma. About 43 participants will receive the drug combination, and researchers will measure how well the tumors shr…

This study tests whether giving focused radiation to large tumors before CAR-T cell therapy can improve cancer control in people with aggressive large B-cell lymphoma. About 27 participants with tumors at least 5 cm will receive the combined treatment. The goal is to see if this …

This study tests whether adding the targeted drug abemaciclib to precise radiation (stereotactic radiosurgery) can better control breast cancer that has spread to the brain. It is for people with a specific type of breast cancer (HR+/HER2-). The goal is to see how long the cancer…

This study tests whether the drug afatinib can shrink tumors in people with advanced squamous cell skin cancer that can't be treated with surgery or radiation. About 25 adults will take afatinib pills daily. The main goal is to see how many patients have their tumors shrink or di…

This early-phase study tests whether combining two chemotherapy drugs—CPX-351 and gemtuzumab ozogamicin—is safe for adults newly diagnosed with acute myeloid leukemia (AML). About 18 participants aged 18 to 70 will receive the drugs to find the best dose that limits side effects.…

This study tests whether ruxolitinib works better than the standard steroid prednisone as the first treatment for chronic graft-versus-host disease (cGVHD), a complication after bone marrow transplant. About 120 adults who need systemic therapy for cGVHD will be randomly assigned…

This study tests a CAR T-cell therapy called KTE-X19 in adults with B-cell acute lymphoblastic leukemia (B-ALL) who are in remission but still have tiny amounts of cancer cells (minimal residual disease, or MRD). The goal is to see if the treatment can eliminate these hidden cell…

This study tests a new way of giving already-approved drugs to people with hormone-positive metastatic breast cancer. The idea is to use two different treatments in a row, like a 'first strike' and 'second strike,' to make them work better. The study will include 15 women and wil…

This study tests whether two drugs, cemiplimab and ziv-aflibercept, can shrink or stop the growth of metastatic uveal melanoma, a rare eye cancer that has spread to other parts of the body. About 32 adults with this condition will receive the combination treatment. The main goal …

This early-stage study tests a combination of two drugs, Vyxeos and Gilteritinib, for adults with a specific genetic form of acute myeloid leukemia (FLT3-mutated) that has returned or not responded to prior treatment. The goal is to find the safest dose and see how well it contro…

This study tests whether using a tumor's genetic profile to customize radiation doses can better control triple negative breast cancer after lumpectomy. About 86 participants will receive radiation tailored to their individual risk, with the goal of preventing cancer from returni…

This study tests a two-step treatment for people with a rare eye cancer (uveal melanoma) that has spread only to the liver. First, a chemotherapy drug is delivered directly to the liver through a special procedure. Then, a targeted immunotherapy drug is given to help the immune s…

This study compares four different dosing schedules of the drug vismodegib in 34 adults with advanced basal cell carcinoma. The goal is to see if personalized, intermittent dosing works as well as continuous daily dosing while reducing side effects. Participants will be followed …

This study tests if automated, personalized text messages can help 800 smokers living with HIV in Cambodia quit smoking. Participants will receive tailored messages and set a quit date within two weeks. The study will check if they have stopped smoking after 3 and 6 months using …

This study tests whether adding the immunotherapy Sipuleucel-T (Provenge) to standard hormone therapy can better control metastatic prostate cancer that has started to progress. About 26 men with asymptomatic or mildly symptomatic disease will be randomly assigned to receive Sipu…

This study tests a combination of two drugs, ACR-368 and low-dose gemcitabine, in people with head and neck cancer that has come back or spread. The goal is to see if the treatment can shrink tumors and how safe it is. About 43 adults will receive the drugs every two weeks as lon…

This study tests whether adding the targeted drug pirtobrutinib to standard CAR T-cell therapy can better control mantle cell lymphoma that has come back or stopped responding to treatment. About 60 adults will be randomly assigned to receive the drug before or after the cell inf…

This early-stage trial tests a special immune cell therapy (CD40L TIL) combined with the drug nivolumab for people with advanced non-small cell lung cancer that has specific gene changes (EGFR, ALK, ROS1, or HER2). About 20 adults whose cancer worsened after standard treatments w…

This study tests a program that gives extra nutrition help to people recovering from pancreatic cancer surgery. Participants use a mobile app to log their meals and get support from a dietitian. The goal is to see if the program is easy to use and helps patients stay nourished. A…

This study looks at whether a short exercise program before surgery (called prehabilitation) is practical and helpful for people with esophageal cancer. About 20 patients will take part to see if they stick with the program and if it improves their recovery. The goal is to make s…

This study tests whether eating lots of fermented foods (like yogurt, kimchi, and sauerkraut) can help standard cancer treatments work better in people with rectal or lung cancer. Researchers will see if this diet improves tumor response, gut health, and quality of life. About 54…

This study tests whether using MRI scans to adjust radiation therapy can reduce damage to nearby healthy organs in people with head and neck cancer. About 35 participants will receive a personalized radiation boost based on how their tumor responds. The goal is to lower side effe…

This study tests a program called STRONG that provides remote nutrition guidance and support to people with gastroesophageal cancer. The goal is to see if it helps reduce malnutrition compared to usual care. About 80 adults starting chemotherapy or radiation will participate. The…

This study tests whether a remote exercise and nutrition program before surgery can help people with pancreatic cancer get stronger and recover better. About 26 adults with borderline resectable pancreatic cancer will take part. The program is done at home and focuses on improvin…

This study tests whether a diet called MIND can improve memory, focus, and thinking in breast cancer survivors who have ongoing 'brain fog' after treatment. Researchers will enroll 200 women who finished treatment 6 months to 3 years ago. Participants will follow the MIND diet fo…

This study enrolls people with pancreatic cysts or lesions to collect blood, tissue, and scan data. Researchers will use this information to develop noninvasive tools that predict which cysts may become cancerous. The goal is to help doctors make better treatment decisions withou…

This study enrolls 318 Black patients with advanced non-small cell lung cancer to see how well the immunotherapy drug pembrolizumab (with or without chemotherapy) works in real-world settings. Researchers will track survival and tumor progression, and look for biomarkers in the b…

This study looks at whether regular brain MRIs can find cancer that has spread to the brain in people with stage IV breast cancer who have no brain symptoms. About 170 adults with different types of breast cancer will get brain scans at the start and again after 6 months or when …

This study aims to create a mobile health (mHealth) system to help cancer patients stop smoking. Researchers will test if the system is easy to use and acceptable to patients. About 90 adult cancer patients who smoke will take part. The goal is to build a resource that can be use…

This study looks at whether certain substances in the blood and tumor tissue can help doctors tell if a lung nodule is cancer or not, predict if cancer will come back after surgery, and catch late recurrences. About 250 adults with suspicious lung nodules will provide samples and…

This study looks at how often breast cancer that has spread to lymph nodes also spreads to other parts of the body after chemotherapy and surgery. About 120 people will get CT scans at the start and again after 6 months to check for any hidden spread. The goal is to learn more ab…

This study offers cancer education and outreach to 1,200 adults in Florida and Puerto Rico. The goal is to increase cancer awareness, community engagement, and participation in cancer research. Participants attend workshops, training, and events to learn about cancer prevention a…

This study is testing whether a group of experts, called the Evolutionary Tumor Board, can come up with new treatment plans for 35 people whose cancer is considered incurable. The goal is to see if they can create a different plan for at least 80% of participants. This is a resea…

This study follows 100 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are starting treatment. Researchers will measure quality of life, fatigue, and symptoms at several points over two years to see how different treatments affect daily livi…

This study tests whether outreach, navigation, and digital tools can help more Black and Hispanic patients join cancer treatment trials. Researchers will compare enrollment rates in areas that receive the intervention versus those that do not. The goal is to make cancer research …

This study looks at whether a special type of PET scan (PSMA-PET) can find early signs of prostate cancer that has spread in men who had a high-risk gene test (Decipher score >0.45). The study will include 60 men who were already part of a larger study. They will get a PSMA-PET s…