New combo tackles both sides of rare blood disease
NCT ID NCT06327685
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 29 times
Summary
This early-phase study tests whether combining two drugs—avapritinib and decitabine—can safely control both parts of a rare blood cancer called systemic mastocytosis with an associated hematologic neoplasm (SM-AHN). About 34 adults with this condition will receive the combination to find the best dose and check for side effects. The goal is to improve disease control without causing too many extra side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
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Mayo Clinic - Arizona
NOT_YET_RECRUITINGPhoenix, Arizona, 85054, United States
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Memorial Sloan Kettering Cancer Center
NOT_YET_RECRUITINGNew York, New York, 10065, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Stanford University Medical Center
NOT_YET_RECRUITINGPalo Alto, California, 94305, United States
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University of Michigan
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Utah Health
RECRUITINGSalt Lake City, Utah, 84132, United States
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Conditions
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