H. Lee Moffitt Cancer Center And Research Institute

This study is testing whether a new smartphone app that uses augmented reality can help people quit smoking. The app is designed to be used alongside standard telephone counseling from a quitline. Researchers want to see if people who use the app in addition to counseling are mor…

This early-stage trial is testing a personalized vaccine for patients with high-risk triple-negative breast cancer who still have cancer cells after standard chemotherapy. Doctors create a custom vaccine from the patient's own tumor and immune cells, aiming to train the body's de…

This study is testing whether adding a targeted radiation treatment and an immunotherapy drug to a standard chemotherapy drug works better and is safe for people with a hard-to-treat type of breast cancer that has spread to the brain. It will involve about 31 adults with metastat…

This study is testing an experimental drug called enfortumab vedotin for people with advanced colorectal cancer or liver cancer that has spread and has not responded to standard treatments. The goal is to see if the drug can shrink tumors and control the cancer. The trial will en…

This study is testing whether adding a targeted drug called abemaciclib to precise radiation treatment can better control breast cancer that has spread to the brain. It is for people with a specific type of breast cancer (hormone receptor-positive, HER2-negative) who have a limit…

This early-stage trial is testing whether a patient's own immune cells, modified in a lab to be more powerful, can help fight advanced lung cancer when given alongside the immunotherapy drug nivolumab. The study is for adults with specific genetic changes in their lung cancer who…

This study is testing whether the drug luspatercept can help adults with certain lower-risk blood disorders (MDS or MDS/MPN) who have anemia and require regular blood transfusions. Participants will receive luspatercept along with standard supportive care to see if it reduces the…

This study is testing the safety of adding a new drug called calaspargase pegol to a standard chemotherapy regimen for young adults newly diagnosed with acute lymphoblastic leukemia. Researchers want to see if this combination is safe and can help patients achieve and maintain re…

This study is testing a combination of three immunotherapy drugs (Interleukin-2, ipilimumab, and nivolumab) for people with advanced, inoperable melanoma. It is specifically for patients whose cancer has continued to grow despite prior treatment with a common type of immunotherap…

This study is testing whether adding a maintenance drug called elranatamab after CAR-T cell therapy can help keep myeloma from returning in high-risk patients. It will enroll 39 adults with relapsed myeloma who have already received CAR-T cell treatment but have features that mak…

This study is testing whether radiation therapy followed by two targeted cancer drugs delivered directly into the spinal fluid is safe and can help people live longer. It's for patients with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. T…

This study is testing whether combining two existing drugs, cemiplimab and Ziv-aflibercept, is safe and can help control metastatic uveal melanoma, a rare and aggressive cancer that starts in the eye. The goal is to see if this combination can shrink tumors or stop them from grow…

This study is testing a new approach to radiation therapy for triple negative breast cancer. After a lumpectomy, doctors will use a genetic test on the tumor to determine if a patient should receive a standard or a higher dose of radiation. The goal is to see if this personalized…

This early-stage study is testing a personalized immune vaccine for breast cancer patients whose cancer has spread to the membranes surrounding the brain and spinal cord. Researchers will inject the vaccine directly into the spinal fluid to see if it's safe and to find the highes…

This study is testing a new combination of four drugs for people with advanced stomach or esophageal cancer that has a specific genetic feature called HER2. The goal is to see if adding the drug neratinib to standard chemotherapy and two other targeted drugs is safe and more effe…

This study is testing whether using special imaging analysis can help doctors aim higher doses of radiation at the most aggressive parts of a sarcoma tumor before surgery. The goal is to see if this targeted approach kills more of the tumor, making it easier for surgeons to remov…

This study is testing whether combining two drugs, ACR-368 and a low dose of gemcitabine, can help control advanced head and neck cancer that has returned or spread. It will involve 43 patients who have already tried standard immunotherapy. Participants will receive the drug comb…

This early-stage study aims to find the safest and most effective dose when combining two chemotherapy drugs, CPX-351 and gemtuzumab ozogamicin, to treat newly diagnosed acute myeloid leukemia (AML). Researchers will enroll up to 18 adult patients to test different dose levels an…

This study is testing whether giving immunotherapy drugs before surgery can lead to better outcomes for people with advanced melanoma that has spread to nearby lymph nodes or tissue. The treatment aims to help the patient's own immune system attack the cancer to shrink tumors pri…

This early-stage study is testing if adding aspirin to standard chemotherapy helps the body's immune system better fight ovarian, fallopian tube, or peritoneal cancer. It will involve 100 adults who are scheduled for chemotherapy before surgery. Researchers will measure changes i…

This study is testing whether a cancer vaccine called Sipuleucel-T works better when patients continue taking their standard hormone therapy drugs. It's for men with advanced prostate cancer that has spread but isn't causing major symptoms, and whose PSA levels are rising despite…

This study is testing whether a combination of two drugs, dostarlimab and niraparib, can help control advanced penile cancer that has continued to grow after standard chemotherapy. It will involve about 25 men with this specific type of cancer. The main goal is to see if the trea…

This early-stage trial is testing a new schedule of chemotherapy drugs for patients with widely spread Ewing's sarcoma, a rare bone and soft tissue cancer. The approach uses an initial strong treatment to shrink the main tumor, followed by a series of follow-up treatments and lon…

This study is testing whether KTE-X19, a type of CAR T-cell therapy, can help adults with B-cell acute lymphoblastic leukemia who are in remission but still have tiny amounts of cancer cells detectable in their bone marrow. The treatment involves collecting and genetically modify…

This study compares four different dosing schedules of the drug vismodegib for people with advanced basal cell carcinoma, a type of skin cancer. Researchers want to see if personalized, on-and-off dosing schedules work better and are more tolerable than standard continuous or fix…

This early-phase study is testing the safety and best dose of a two-drug combination (Vyxeos and gilteritinib) for adults with a specific type of acute myeloid leukemia (AML) that has a FLT3 mutation and has returned or not responded to prior treatment. The goal is to see if this…

This study is testing whether adding a drug called venetoclax to a standard chemotherapy combination works better for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatment. Researchers want to see if this approach helps clear more cancer c…

This study is testing whether combining two existing drugs, axitinib and ipilimumab, can help control advanced melanoma in patients whose cancer didn't respond to previous immunotherapy. The trial will enroll 25 adults with advanced melanoma who have already tried anti-PD-1/PD-L1…

This study is testing whether adding a personalized vaccine to standard chemotherapy and targeted drugs can better treat HER2-positive breast cancer before surgery. The vaccine is made from the patient's own immune cells and aims to train the body to attack the cancer. Researcher…

This study is testing a two-step treatment for patients with large B-cell lymphoma that has come back or hasn't responded to other treatments. First, patients receive targeted radiation to all visible cancer sites to shrink large tumors. Then, they receive a personalized immune c…

This early-stage trial is testing a personalized cell therapy for people with advanced melanoma that hasn't responded to standard treatments. Doctors take immune cells from a patient's own tumor, boost them in the lab with a protein called CD40L, and then infuse them back into th…

This study is testing whether adding a pill called pirtobrutinib to a cell-based therapy (CAR T) works better for people with mantle cell lymphoma that has come back or stopped responding to treatment. The trial will enroll 60 adults to see if the combination helps patients live …

This study is testing a two-step treatment for people with a rare and aggressive eye cancer (uveal melanoma) that has spread mainly to the liver. First, doctors use a procedure to deliver high-dose chemotherapy directly to the liver. The goal is to damage the tumors and potential…

This study is testing whether a combination of two drugs (tafasitamab and lenalidomide) can help people with large B-cell lymphoma who still have cancer after receiving CAR-T cell therapy. The research aims to see if this treatment is safe and effective at eliminating or reducing…

This study is testing an immunotherapy drug called pembrolizumab for adults with advanced cutaneous sarcoma, a rare type of skin cancer. The goal is to see if the drug can shrink tumors and help control the disease. About 17 participants will receive the drug through an IV every …

This study is testing a new strategy for treating advanced breast cancer that has spread. Researchers want to see if giving a specific sequence of already-approved drugs is practical and might work better than current approaches. The study will involve 15 women with a specific ty…

This early-stage study is testing the safety of a new treatment for ovarian cancer that has returned after previous therapies. Doctors take a patient's own immune cells (T cells), modify them in a lab to better recognize cancer, and then infuse them back into the body. The main g…

This study is testing whether an automated text messaging program can help people living with HIV in Cambodia quit smoking. It will enroll 800 adult smokers with HIV who are willing to try to quit. Researchers will check if participants have quit by asking them and using a breath…

This early-stage study is testing the safety of a new combination treatment for people with metastatic HER2-positive breast cancer. It uses a personalized vaccine to train the immune system, followed by an infusion of specially grown immune cells, alongside standard medications. …

This is an early safety study testing a new two-part treatment for advanced breast cancer that has spread. It combines a personalized vaccine made from a patient's own immune cells with a hormone-blocking pill. The goal is to see if this combination is safe and feasible for patie…

This early-stage study is testing the safety of combining two drugs, avapritinib and decitabine, for patients with a rare and complex blood cancer called SM-AHN. The goal is to find a dose that is safe and tolerable while trying to control both the mast cell and the blood cell pa…

This study is testing if digoxin, a medication commonly used for heart conditions, can help control a rare and aggressive brain cancer called medulloblastoma when it has come back after initial treatment. It will involve about 23 children and young adults (ages 1-30) whose cancer…

This study is testing whether giving two drugs, cetuximab and cemiplimab, before surgery can help people with head and neck cancer. The goal is to see if this combination can shrink or even eliminate the tumor, which might lead to better long-term results. The trial will enroll 2…

This study aims to find the better first treatment for chronic graft-versus-host disease (cGVHD), a serious complication that can occur after a bone marrow transplant. Researchers will compare two drugs—ruxolitinib (already approved for later treatment) and prednisone (current st…

This study is testing how well the immunotherapy drug pembrolizumab, with or without chemotherapy, works for Black patients with advanced non-small cell lung cancer. It aims to see how long patients live and how long the cancer stays controlled, while also looking for markers in …

This study is testing a two-step treatment for advanced prostate cancer that has become resistant to standard hormone therapy. First, men receive high-dose testosterone, followed by a targeted radiation drug that seeks out and destroys cancer cells. The goal is to see if this com…

This early-stage study is testing a new type of personalized vaccine, made from a patient's own immune cells, given directly into the tumor along with standard chemotherapy. It aims to see if this combination is safe and can help shrink tumors in people with aggressive forms of b…

This study is testing a combination of two existing drugs, olaparib and pembrolizumab, to see if they can work together to control advanced uveal melanoma, a rare and aggressive cancer that starts in the eye. It will involve about 37 adults whose cancer has spread. The main goal …

This study is testing whether the drug afatinib can help control advanced skin cancer that can't be treated with surgery or radiation. It's for people whose cancer has continued to grow despite trying immunotherapy. Researchers will measure if tumors shrink, how long the cancer s…

This study is testing whether combining two existing drugs—rituximab and zanubrutinib—is safe and effective for people with untreated slow-growing B-cell lymphomas. It will enroll 43 adults with either follicular lymphoma or marginal zone lymphoma who need systemic treatment. Res…

This study is testing whether eating more fermented foods like yogurt, kimchi, and kombucha can help people with rectal or lung cancer. Researchers want to see if this special diet makes standard cancer treatments like chemotherapy and immunotherapy work better. They will also ch…

This early-stage trial is testing a new type of immune cell therapy for men with advanced prostate cancer that has spread to bones and no longer responds to standard hormone treatments. Doctors will collect patients' own immune cells, modify them in a lab to better target prostat…

This study is testing if taking a daily pill called itacitinib for about a month before receiving a specialized cell therapy (CAR-T) can improve results for adults with an aggressive type of lymphoma. The researchers want to see if this approach helps control the cancer longer an…

This study is testing if a drug called asciminib is safe and can help prevent a serious type of leukemia from returning in adults. It's for people who are in remission after receiving either a stem cell transplant or CAR T-cell therapy. The main goals are to find a safe dose and …

This study tests whether treatment decisions for advanced melanoma can be personalized based on how well tumors respond to drug therapy before surgery. Patients with specific genetic mutations receive targeted drugs before surgery, then get different follow-up treatments dependin…

This study is testing whether adults with newly diagnosed acute myeloid leukemia (AML) who have achieved deep remission can safely stop their chemotherapy for a period after one year of treatment. Researchers want to see if taking a break from treatment reduces side effects while…

This early-stage study is testing a medication called ropeginterferon for people with advanced cutaneous T-cell lymphoma (CTCL), a type of skin cancer. The main goals are to find the safest and most effective dose and to see how well the drug works in patients whose disease hasn'…

This study aims to improve lung cancer care by testing whether specific biomarkers in blood and tissue can better diagnose lung nodules, identify patients at high risk of cancer returning after surgery, and detect late recurrence. Researchers will follow 250 adults with suspiciou…

This study aims to develop better tools to predict which pancreatic cysts might turn into cancer. Researchers will collect medical scans, blood samples, and health information from over 1,100 people with pancreatic cysts or tumors. By analyzing this data, they hope to create non-…

This study is testing a new oral swab that looks for specific markers linked to HPV-related throat cancer. The goal is to see if this simple test can accurately find cancer early, when treatment is often more successful. Researchers will compare results from 200 people with throa…

This study is testing a new type of imaging scan called PSMA-PET to see if it can better detect prostate cancer that has returned or spread in men who are at high risk based on a genetic test. It will enroll 60 men who previously had high-risk genetic test results and were treate…

This study aims to find out if personalized messages about skin cancer risk can encourage people to adopt better sun protection habits. Researchers will enroll 2,900 adults from community health centers who have recently tanned or gotten sunburned. Participants will receive diffe…

This study is testing a new Spanish-language program called ProSalud, which aims to teach Latino parents in rural Florida about healthy habits to lower their family's cancer risk. Parents attend a workshop about nutrition, exercise, and sun safety, and some are later asked for fe…

This study is testing whether a remote nutrition support program can help people with stomach or esophageal cancer maintain their weight and nutritional health during cancer treatment. The program provides virtual dietitian visits and a food tracking app to 80 patients receiving …

This study is testing whether a remote exercise and nutrition program is practical and helpful for people preparing for pancreatic cancer surgery. Researchers want to see if patients can complete the program and if it improves their strength and recovery. The study will compare o…

This study is testing whether a remote support program can help pancreatic cancer patients maintain their weight and nutrition after surgery. The program provides extra access to a dietitian and uses a mobile app for food tracking. Researchers want to see if patients find it help…

This small pilot study is testing whether an exercise program before surgery is practical and acceptable for people with esophageal cancer. Researchers want to see if patients can complete the exercise program and if it might help with recovery after surgery. The study involves 2…

This study is testing whether following the MIND diet can help improve memory, focus, and thinking problems (often called 'chemo brain') in breast cancer survivors. It will involve 200 women who have finished their main cancer treatment but still report cognitive issues. Particip…

This study is testing if a guided, at-home strength training program is safe, practical, and helpful for people with advanced stomach or intestinal cancer who are undergoing chemotherapy. Researchers will enroll 100 participants to see if the program improves muscle strength, red…

This study aims to find out how often breast cancer spreads to other parts of the body after patients complete chemotherapy and surgery. Researchers will use CT scans to check 120 patients with node-positive breast cancer at two time points: right after treatment and again six mo…

This study aims to understand how daily life, fatigue, and symptoms change over two years for adults receiving treatment for chronic lymphocytic leukemia or small lymphocytic lymphoma. Researchers will follow 100 patients who are starting specific cancer medications, tracking the…

This study has two main goals. First, it's testing a computer program (AI) to see if it can spot early signs of severe weight and muscle loss in people with pancreatic cancer. Second, it's checking how practical and acceptable diet and exercise plans are for patients to help mana…

This research study aims to understand how obesity contributes to pancreatic cancer development, particularly in African American and Non-Hispanic White populations. Researchers will collect tissue samples and medical data from 125 adults who have or are suspected to have pancrea…

This study is testing whether a special team of doctors and scientists can create new, personalized treatment plans for people with incurable cancer. It will enroll 35 patients who have run out of standard curative options. The main goal is to see if this team can successfully de…

This study aims to find out if regular brain MRI scans can detect cancer that has spread to the brain in patients with advanced breast cancer who have no neurological symptoms. Researchers will enroll 170 patients with stage IV breast cancer to see how often these scans find hidd…

This study is testing new outreach and education strategies to increase enrollment of Black and Hispanic patients in cancer treatment trials at Moffitt Cancer Center. Researchers will work with community members, doctors, and patients using educational sessions, digital tools, an…

This study is testing a new approach to help children and young adults whose cancers are considered incurable or not responding well to standard treatments. A special team of doctors from different hospitals will review each patient's case to see if they can suggest new, personal…

This study aims to increase cancer awareness and encourage participation in cancer research through community education programs. Researchers will work with 1,200 adults in Florida and Puerto Rico, offering online training, workshops, and podcasts in both English and Spanish. The…