Duke University

This phase 2 trial is testing whether giving the immunotherapy drug atezolizumab before surgery can help people with recurrent glioblastoma, a type of aggressive brain cancer. Researchers want to see if the drug works better in patients with certain genetic markers (tumor mutatio…

This study tests whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in daily smokers who have chronic pain and are on buprenorphine for opioid use disorder. 60 participants will be randomly assigned to either very low or normal nicotine ci…

This study tests if transplanting the abdominal wall (the muscles and skin covering the belly) can safely repair large defects. It is for people who also need or have had an organ transplant, like a kidney or liver. The main goal is to see if the transplanted belly wall is still …

This study tests an oral drug called deferiprone in people who have had a brain bleed from a ruptured aneurysm. The drug aims to safely remove excess iron that builds up after the bleed and may cause memory loss and brain damage. About 66 adults will receive either the drug plus …

This study looks at whether donepezil, a drug already used for Alzheimer's, can improve bone health and lower fracture risk in older adults with mild to moderate Alzheimer's. About 45 participants will take either donepezil or memantine daily for 12 months. Researchers will measu…

This study tests a program called CO-LEAD that trains doctors to use effective communication strategies and a patient survey to identify barriers to taking lupus medications. Researchers will enroll 480 patients and their clinicians at two academic centers. The goal is to see if …

This study tests montelukast, an asthma drug, in 28 premature infants at high risk for bronchopulmonary dysplasia (BPD), a serious lung condition. Researchers want to see if the drug is safe and how it moves through the body. The infants receive montelukast or a placebo daily for…

This study is testing an education program for people with type 2 diabetes who also have chronic kidney disease. The program provides patients with information about their kidney health and suggests medications that could slow kidney damage. Researchers will see if this approach …

This study tests whether blocking a nerve in the abdomen (the splanchnic nerve) can reduce congestion and improve exercise capacity in people with heart failure. The procedure uses a catheter to ablate the nerve, and results are compared to a sham procedure. Fifty-four adults wit…

This study tests a 6-month holistic program that offers counseling, peer support, and education to people living with HIV or seeking HIV prevention. Researchers want to see if it improves depression, anxiety, substance use, and social support. About 200 adults in North Carolina w…

This study looks at children with juvenile idiopathic arthritis (JIA) whose first treatment (a TNF inhibitor) did not work well enough. It compares three different medications to a second TNF inhibitor to see which works better at reducing disease activity. The goal is to find th…

This phase 2 trial tests whether adding two immunotherapy drugs, nivolumab and relatlimab, to standard treatment can help the immune system fight glioblastoma, an aggressive brain cancer. About 92 adults with newly diagnosed tumors will receive the drugs before and after surgery.…

This early-stage study tests whether transplanting healthy gut bacteria can help people with rapidly progressing ALS. Twenty adults will receive the transplant after a short course of antibiotics. Researchers will track changes in muscle function, quality of life, and nerve damag…

This study looks at whether helping families with food benefits can improve weight in infants who are already overweight and at risk for food insecurity. About 228 infants aged 12 months and their parents will get $50 per week for one year, either as cash or as guided grocery sho…

This early-stage study tests a modified herpes virus (MVR-C5252) injected directly into brain tumors in people with recurrent high-grade glioma. The main goals are to find a safe dose and see if the virus can shrink tumors or slow their growth. About 51 adults with tumors that re…

This early study tests whether giving an IL-17 blocker (secukinumab) alongside restarting immunotherapy can lower the risk of severe immune-related side effects in people with advanced melanoma. Only 4 participants who previously had side effects like colitis or rash will be enro…

This study looks at whether doing a stent procedure (TEVAR) early, along with standard medication, can lower the risk of death or serious problems like rupture or stroke compared to medication alone. About 1,100 adults with uncomplicated type B aortic dissection will take part. T…

This study tests whether giving free fruits and vegetables, plus optional health coaching, can reduce emergency visits and hospital stays for adults with congestive heart failure. About 900 participants will be randomly assigned to receive the produce program alone, produce with …

This study tests a new device called the Calla introducer for cervical cancer screening. Researchers want to see if women prefer it over the standard speculum used during Pap smears. About 305 healthy women aged 21-65 will participate. The goal is to improve comfort and screening…

This pilot study tests a new handheld eye imaging device (Theia 1) against an existing system in 30 healthy adults and children. The goal is to see if the new device can capture wider, clearer images of the retina to help diagnose conditions like retinal disease, glaucoma, and op…

This study compares two types of CT myelography scans to detect CSF-venous fistulas, abnormal connections that cause spinal fluid leaks, in 200 adults with spontaneous intracranial hypotension (low-pressure headaches). Participants will be randomly assigned to receive either a ne…

This study tests an electronic decision support tool to help doctors diagnose and treat lower respiratory tract infections. About 765 patients in Sri Lankan hospitals will use the tool, and researchers will compare their outcomes and antibiotic use to those receiving usual care. …

This study compares two newer imaging methods—photon-counting CT and ultrasound—against the standard MRI to see how well they detect fat and scarring in the liver. About 45 adults with liver disease will receive all three scans. The goal is to find a faster, cheaper, and equally …

This study is testing whether a urine test that looks for DNA markers can help diagnose and monitor upper tract urothelial cancer (UTUC), a rare cancer of the kidney and ureter. Researchers will collect urine samples from 50 patients before surgery and during follow-up visits. Th…

This study is testing a small, AI-powered camera called the Pocket colposcope to see if it can accurately detect early signs of cervical cancer in women who have tested positive for HPV. About 1,054 women in Kenya will use the device during a routine exam. The goal is to find a s…

This study involves 30 adults with bladder cancer who are scheduled to have their bladder removed. Right before surgery, doctors will use a special ultrasound technique called Super-Resolution Ultrasound Localization Microscopy to check for any remaining cancer. The results will …

This study aims to develop better ways to measure eye pressure, which is important for diagnosing and managing glaucoma. Current methods are either subjective or not portable. Researchers will compare two new devices to standard methods in 200 adults getting routine eye exams. Th…

This study is testing a device called SenseToKnow that uses video and a caregiver survey to help detect autism in children aged 16 to 36 months. The goal is to see how accurate the device is compared to a doctor's diagnosis. About 350 children from Duke Health will take part.

This study is testing whether a special imaging agent called Tc 99m Tilmanocept can spot inflammation in the heart caused by sarcoidosis. About 15 adults with confirmed sarcoidosis will receive this agent and undergo a SPECT/CT scan. The results will be compared to standard PET s…

This study tests a new blood test that looks at proteins in platelets (a type of blood cell) to see if it can find prostate cancer more accurately than current methods like PSA tests and biopsies. Researchers at Duke University will enroll 300 men who are already being checked fo…

This study is testing a new handheld device that automatically aligns to take detailed pictures of the retina (the back of the eye). Researchers want to see if it works well in healthy adults, adult eye patients, and children with eye conditions like glaucoma or retinal disease. …

This study tests whether giving HIV prevention pills (PrEP) on a medical van is a good way to reach people who inject drugs and are at high risk for HIV. The researchers will enroll 20 adults who use drugs or are sexually active and see how many start and stay on PrEP. The goal i…

This study looks at whether giving infants an RSV preventive antibody at the same time as their regular vaccines is safe. About 524 babies aged 6 weeks to under 30 weeks will take part. Researchers will compare fever rates in babies who get the RSV shot together with vaccines ver…

This study tests a new online program called UPDOs Protective Styles to help Black women in the southeastern United States learn about and start using PrEP, a medicine that prevents HIV. About 1000 women from 32 beauty salons will either use the program (videos, blogs, and telehe…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This large study is testing whether taking atorvastatin (a statin) can help healthy adults aged 75 and older avoid dementia, disability, and death. Participants are randomly assigned to take either the drug or a placebo for several years. The goal is to see if this simple pill ca…

This pilot study is testing whether a remotely-delivered exercise program is practical and acceptable for people recently diagnosed with rheumatoid arthritis (within 6 months). Fifteen participants will receive intensive aerobic and resistance training via video calls. The main g…

This study tests whether applying minoxidil (a hair growth drug) to the breasts for two weeks before surgery can improve blood flow and tissue survival in women undergoing preventive mastectomy with reconstruction. Twenty-five women at high genetic risk for breast cancer will hav…

This study compares a single dose of methadone (a long-acting opioid) given during surgery to standard short-acting opioids for pain relief after tonsillectomy in children ages 3 to 17. The goal is to see if methadone reduces the need for extra pain medication in the recovery roo…

This study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …

This study tests a program called Nite2Day+ that uses mindfulness and sleep tips to help people with blood cancers sleep better and manage fatigue, stress, and pain. About 60 adults hospitalized for treatment will either get the program or standard care. The program includes a mo…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have an eating disorder. About 235 people aged 16–50 will be assigned to ACT, supportive diabetes counseling, or a waitlist. Researchers wi…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program uses video sessions and online materials to teach skills for managing symptoms like pain, fatigue, and emotional distress, and to encourage follow-up care. Rese…

This pilot study at Duke University compares two behavioral treatments—organizational skills training (OST) and mindfulness-based intervention (MBI)—for 30 teens aged 13-17 with ADHD. Both treatments involve eight 90-minute sessions. Researchers will measure changes in ADHD sympt…

This pilot study tests a behavioral program called Mindset Moments for young adults (ages 19-25) who have finished cancer treatment. The program includes weekly online group sessions and daily app activities focused on coping skills, mindfulness, and peer support. Researchers wan…

This study is creating and testing a nurse-led program for women who go through early menopause after cancer treatment. The program includes education, decision support, and skills to manage menopause symptoms. Researchers want to see if the program is easy to use and helpful for…

This study tests whether simple online exercises—like writing a gratitude letter—can boost well-being and reduce burnout in adults, especially healthcare workers. Up to 8,000 participants will try one or more tools and complete surveys over a year. The goal is to see if these bri…

This study looks at whether two types of liver cancer treatments—procedures done by radiologists or targeted radiation—can improve quality of life for patients who cannot have surgery. About 78 adults with liver cancer will fill out questionnaires before and after treatment. The …

This study tests whether doing a short exercise routine just before radiation therapy can improve arm or leg function and reduce wound problems after surgery for soft tissue sarcoma. About 24 adults with sarcoma in an arm or leg will take part. They will use rubber bands or a han…

This study tests a short, phone-based pain coping skills program for women aged 55 and older with breast cancer who have ongoing pain. Participants will learn techniques to manage pain and improve their quality of life through one main session and five brief follow-up calls. The …

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face anxiety, depression, and PTSD, but mental health care is hard to access. The app aims to help them manage these symptoms on their own…

This study tests whether a 10-week online skills program based on dialectical behavior therapy (DBT) can help pregnant women with high emotional distress feel less stressed and have a healthier heart rate. About 100 women who are at least 12 weeks pregnant and have trouble managi…

This study tests a mobile app called ICUconnect that helps older ICU patients and their families report their needs to doctors. The goal is to improve care and reduce emotional distress. About 350 patient-family pairs will take part across four hospitals.

This study compares spinal anesthesia to general anesthesia for a procedure that loosens stiff knees after replacement surgery. About 128 adults will take part to see which method improves knee movement and reduces pain better. The goal is to find the best way to make the procedu…

This study tests whether training caregivers of young autistic children (18–72 months) in South Africa can improve the child's communication and daily living skills. Non-specialist coaches teach caregivers strategies they can use during everyday activities. The goal is to support…

This study tests a telehealth program called ENGAGE for people with stage IV breast, prostate, lung, or colorectal cancer. The program helps manage symptoms like pain, fatigue, and distress that interfere with daily life. About 190 participants will be randomly assigned to ENGAGE…

This study tests a 12-week exercise and nutrition program called SickleFit in 40 adults aged 35 and older with sickle cell disease. The goal is to see if the program is safe, doable, and liked by participants. It does not aim to cure the disease but to improve fitness and quality…

This study aims to see if offering a menu of pain control options before getting an IUD helps patients feel more in control, satisfied, and less pain. About 200 people getting an IUD will answer surveys before and after the menu is introduced. The goal is to improve the IUD inser…

This study tests whether a month of personalized calming music at bedtime can improve sleep for people with dementia and reduce stress for their caregivers. About 144 participants (72 pairs of a person with dementia and their caregiver) will use a mobile app. The goal is to see i…

This study tests whether a mobile app and headset that train the brain to relax can help people with chronic low back pain. 150 adults will use the app for 10 minutes, four times a week for three months. Researchers will check pain levels and physical function over nine months.

This study tests a home-based exercise program for people who were hospitalized with severe COVID-19. Participants use a smartphone app to guide them through high-intensity interval training and other exercises. The goal is to see if this approach improves walking ability, fitnes…

This study tests whether using a cold wrap plus compression (cryocompression) is better than cold wraps alone at preventing nerve damage from chemotherapy in people with gynecologic cancer. About 190 participants will wear the device during chemo sessions and report their symptom…

This study tests whether using virtual reality (VR) can help patients in the intensive care unit (ICU) become more active and improve their mental well-being. Researchers will enroll 60 adults who have been in the ICU for at least 3 days and have limited mobility. Participants wi…

This study tests a program that combines in-person coaching with a smartphone app to help people who have had a stem cell transplant or CAR-T therapy cope with pain, fatigue, and stress. The goal is to help them become more active and reduce physical disability. About 177 adults …

This study is creating a collection of blood samples from 300 adults with primary or metastatic brain tumors treated at Duke Cancer Center. Researchers will measure immune cells in the blood to better understand these tumors. The samples will be stored for future studies, not to …

This study is testing three different doses of a non-invasive brain stimulation technique called rTMS in 26 chronic stroke survivors with arm weakness. The goal is to see which dose best boosts brain signals to the hand muscles and improves motor learning. Participants will recei…

This study looks at how children with leukemia process common medicines like painkillers, diuretics, and antibiotics. Researchers will measure drug levels in the blood to better understand dosing. The goal is to make these drugs safer and more effective for kids. No new treatment…

This observational study follows up to 20,000 children and young adults with pediatric-onset rheumatic diseases, such as juvenile idiopathic arthritis. Researchers collect data on treatments, safety, and long-term outcomes to better understand these conditions. The registry does …

This study tests an interactive iPad tool to teach families about acute kidney injury (AKI) in children. Researchers will measure whether the tool improves understanding by comparing test scores before and one month after use. The study involves 25 hospitalized children aged 1 to…

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This natural history study follows 200 children and adults with hypophosphatasia, a rare genetic disorder that weakens bones and teeth. Researchers will collect medical history, track disease progression, and assess quality of life over time. The goal is to better understand the …

This study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the inf…

This study looks at how tough childhood experiences might change brain function and make young adults more likely to start smoking. Researchers will give 150 non-smokers aged 18-21 a tiny dose of nicotine or a placebo nasal spray, then use brain scans and questionnaires to measur…

This study is a registry that will follow up to 3,000 people with idiopathic pulmonary fibrosis (IPF) or other chronic lung scarring diseases. Researchers will collect information on how the disease progresses, what treatments people receive, and how it affects their quality of l…

Latino teens with depression are less likely to get help than their peers. This study talks to teens, parents, and doctors to find out which support strategy — like peer groups, parent-teen training, or care navigation — they prefer. The goal is to improve therapy attendance for …

This study tests a special microscope that takes live 3D images inside the eye during surgery. It aims to help surgeons see better when treating conditions like retinal detachment, macular holes, and cataracts. About 262 people will take part, including healthy volunteers and sur…

This study tests whether a mobile CT scanner, already approved for head scans, can safely take pictures of the chest and belly in children under 5 or those too fragile to move. Researchers will check if the images are good enough for doctors to make a diagnosis. The goal is to ma…

This study observes 60 adults having shoulder surgery to see how often a common numbing shot (interscalene block) temporarily paralyzes one side of the diaphragm. Participants are split into three groups receiving different numbing drugs or a catheter. The main goal is to measure…

This study follows up to 400 children with Pompe disease to see how their immune system reacts to enzyme replacement therapy. Researchers will collect medical records from birth to age 18 to understand which children develop antibodies that block treatment. The goal is to improve…

This study aims to find out why some people with sickle cell disease develop severe, disabling chronic pain while others do not. Researchers will enroll 70 participants aged 15 to 40 and use surveys, virtual visits, and in-person pain sensitivity tests to track pain and related o…

This study at Duke University is testing whether a short questionnaire can accurately estimate a person's oxygen consumption during exercise, compared to a standard sub-maximal exercise test. Researchers will enroll 100 adults scheduled for surgery who have low fitness scores. Th…

This study collects a small sample of tissue from inside the nose to learn how the sense of smell changes in people with Alzheimer's. Researchers will compare samples from healthy volunteers and those with early or mild Alzheimer's. The goal is to understand the biology behind sm…

This study looks at whether sending automated text messages with video advice to people after lumbar fusion surgery can lower the chance of going back to the hospital. About 224 adults having their first lumbar fusion will be split into two groups: one gets the texts, the other g…

This study looks at what makes scuba divers more likely to suffer from oxygen toxicity, which can cause seizures. Researchers will test how breathing muscle training, lack of sleep, common medications, and carbon dioxide affect risk. About 62 healthy adults aged 18-45 will exerci…

This study is for people already in the SYNERGY-201 trial, which tests a drug combination for prostate cancer. Researchers want to see if a marker called CXCR2 can predict who will respond well to the treatment. Blood samples and optional tumor biopsies will be collected over tim…

This study looks at a park-based afterschool program for teens aged 12-17 in Miami-Dade County. Researchers want to see if the program helps with mental health, resilience, physical fitness, and violence prevention. About 1,000 teens will take part, and the study will measure cha…

This study is testing a new type of CT scanner (photon-counting CT) to see if it can measure lung damage from COPD more accurately than current scanners. About 40 adults already in a larger COPD study will get one extra scan. The goal is to improve how doctors track emphysema and…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study tests a new, ultracompact handheld eye scanner to take detailed pictures of the retina in children up to 8 years old with inherited retinal diseases. The goal is to see if this device can detect early signs of vision loss and help doctors monitor the disease over time.…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study looks at what factors—like genetics, immune system, and medical history—affect survival and quality of life in adults with glioblastoma, a severe brain cancer. About 200 participants will fill out an online survey and may provide a blood sample from home. The goal is t…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study follows premature babies previously enrolled in BabySTEPS1 to see if a new, portable eye imaging device can better detect signs of retinopathy of prematurity (ROP), a vision-threatening condition. Researchers will compare the new imaging to standard photos and exams, a…

This study tests whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard care. Sixty adults aged 45 and older who can eat by mouth will be randomly a…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study is observing 500 children and young adults (up to age 26) who are receiving stem cell transplants. Researchers want to understand why some develop serious blood vessel complications, like blockages or organ failure. By collecting blood samples at several time points, t…

This study looks at how certain drugs behave in the bodies of critically ill children under 21 in a heart intensive care unit. Researchers will collect leftover blood samples from routine care to measure drug levels. The goal is to better understand dosing and safety for drugs li…

This study looks at how sleep and internal body clocks work in 250 children aged 6-9 with ADHD. Researchers will use wearable sensors and a lab test to measure sleep timing and melatonin levels. The goal is to see how these factors relate to thinking skills and mental health, whi…

This study tracks 150 adults in cardiac rehab to see if men and women differ in how much they move during and up to 6 months after the program. Participants wear activity trackers and complete fitness tests at three visits over 10 months. The goal is to understand barriers to sta…

This study recruits 600 adults who want to quit smoking. Participants use a smartphone app to take photos of their environment when they smoke and at random times. Researchers use artificial intelligence to analyze these images and identify environmental triggers that lead to rel…

This study is tracking 10,000 orthopedic surgery patients using a smartphone app to measure pain, activity, and opioid use before and after surgery. The goal is to identify which patients are at high risk for long-term opioid use and to create a tool that helps doctors prescribe …

This study compares two approaches to helping children with special health care needs transition from hospital to home. One group gets a single follow-up phone call within 72 hours, while the other gets more extended support. Researchers will track hospital readmissions, emergenc…

This study enrolls people who have had liver injury from prescription drugs or alternative medicines. Researchers will collect data and use FibroScan imaging to track liver health over time. The goal is to build a detailed database to better understand and diagnose these injuries…

This study aims to collect and analyze medical information from 200 people with ultra-rare glycogen storage diseases (GSDs), including types 0a, 0b, VII, X, XII, XIII, XV, PRKAG2 syndrome, and Danon disease. Researchers will track how these conditions progress over time by review…

This study looks for inherited genes that may increase the risk of developing antiphospholipid antibody syndrome (APS), a condition that causes abnormal blood clotting, leading to problems like strokes, heart attacks, and miscarriages. Researchers will recruit 2,800 people with A…

This study looks at how common prescription drugs move from a mother's body into her breastmilk and how much reaches her baby. Researchers will measure drug levels in milk and blood samples from 1,600 breastfeeding women and their infants. The goal is to provide better safety inf…

This study explores whether drones can deliver automated external defibrillators (AEDs) to people experiencing cardiac arrest in rural areas faster than traditional emergency responders. Researchers will compare arrival times and see if drone delivery is practical enough to test …

This study tests a special toilet device that automatically measures urine and stool output in hospital patients. About 54 adults receiving stem cell transplants will use the device during their stay. The goal is to see if the device is as accurate as nurses manually measuring ou…

This study uses a comfortable headband to monitor brain activity and sleep patterns in people with epilepsy who still have seizures despite medication. By tracking sleep and seizures at home for a longer time, researchers hope to learn how poor sleep increases seizure risk. The g…

This study follows 120 men with advanced prostate cancer to see if markers in their blood can predict how well they respond to hormone therapy. Researchers will collect blood samples and compare markers between those who respond well and those who don't. The goal is to develop a …

This study tests different power levels and timing of low-intensity focused ultrasound (LIFUS) to see which best improves arm movement and motor learning in stroke survivors. 24 adults who had a stroke at least 6 months ago and have arm weakness will participate. The goal is to f…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study is creating a registry of 1,000 people with lupus (systemic lupus erythematosus or cutaneous lupus) to collect health information and blood samples over time. The goal is to learn how lupus changes and find better ways to treat it. Participants must be patients at Duke…

This study aims to collect and review medical information from people with Glycogen Storage Disease Type VI (GSD VI) or Type IX (GSD IX) during their regular clinic visits. By gathering data on disease progression, genetic types, and symptoms, researchers hope to better understan…

This study compares a new virtual reality (VR) goggle system called VisuALL to the standard machine-based test for measuring peripheral vision in children and young adults. Researchers will enroll 1000 healthy children and those with eye conditions to see if the VR test works jus…

This study is testing a mobile app called mSaada to help community health workers screen women for cervical cancer in western Kenya. Researchers will work with 6,000 women and health workers to see if the app makes screening easier and more effective. The goal is to find ways to …

This study follows 200 people with Gaucher disease over many years to learn how the condition affects the body long term, including the nervous system, liver, and spleen. Researchers will also review treatment records to see how well enzyme replacement and other therapies work ov…

This study is developing and testing a program to help female adolescent and young adult cancer survivors make informed decisions about building a family after treatment. The program includes four video sessions that provide personalized education about fertility risks and coping…

This study is looking at how a park-based afterschool program called Fit2Play affects the health of children. Researchers will track up to 5,000 kids to see changes in their fitness, weight, blood pressure, and mental well-being. The goal is to understand if community park progra…

This study looks at how a park-based fitness program affects the health of 1,000 adults aged 50 and older in Miami-Dade County. Researchers will measure changes in weight, blood pressure, arm and leg strength, and mobility. The goal is to see if community park programs can help o…

This study tests whether a specially designed play can help reduce stigma around PrEP (pills that prevent HIV) for young women in Kenya. About 160 people, including young women who use PrEP and community members, will watch the play and share their thoughts. The goal is to see if…

This study aims to understand the brain mechanisms behind fear and anxiety in people with anxiety disorders like PTSD and GAD. Researchers will measure brain activity, heart rate, and skin responses while participants view fear-provoking images or use virtual reality. The study i…

This study gathers medical information from 200 people with glycogen branching enzyme deficiency, known as GSD IV or APBD. The goal is to learn how these rare diseases progress over time. No new treatments are tested; instead, researchers review clinic records to better understan…

This study looks at how non-food-related stressors (like work or emotional stress) affect menstrual health in pre-menopausal women. Researchers will measure stress hormones and sex hormones in 600 women over 6 months. The goal is to understand if stress directly causes menstrual …

This study aims to understand how blood vessels around the fovea (a key part of the eye for sharp vision) develop in infants with retinopathy of prematurity, a leading cause of childhood blindness. Researchers will use a special imaging technique (OCTA) to track changes in blood …

This study aims to create a program that helps older adults with lung cancer address concerns related to aging, such as managing symptoms and connecting with specialists. In the first phase, patients, caregivers, and healthcare providers will give feedback on the program material…

This study is testing a new 3D ultrasound technique to measure heart size and function in children and young adults born with only one working heart chamber (single ventricle). Researchers will compare the new method to standard tests like echocardiograms and cardiac MRIs. The go…

This study works with caregivers and doctors to make sure new pain assessment tools are easy to understand and cover all signs of acute pain in children under 2. About 60 caregivers and clinicians will be interviewed. The goal is to create reliable ways to measure pain in future …

This study is a registry that collects information from 300 adults with cancer that has spread to other parts of the body. Participants receive or have received a special type of high-dose radiation called ablative radiotherapy. The goal is to track and understand the short-term …

This study will collect medical information, blood samples, and patient feedback from 2,600 lung transplant candidates, donors, and recipients. The goal is to learn how different care practices affect outcomes like rejection, infection, and survival. Researchers hope to find biom…

This study looks at how Pompe disease affects the brain and nerves over time. Researchers will use brain scans and tests of thinking, language, and movement in 45 people with Pompe disease. The goal is to learn more about long-term health effects, not to test a new treatment.

This study aims to find the best time to ask for consent for a possible cesarean delivery. About 200 pregnant women planning to have labor induced will be randomly assigned to give consent either when they arrive at the hospital or only if it becomes medically needed. After deliv…

This project works to improve how doctors diagnose and treat infections in people with heart devices like pacemakers. It brings together teams of specialists to follow best-practice guidelines. The goal is to identify infections faster and start the right treatment sooner. About …

This study looks at how the brain supports memory when people navigate real and virtual spaces. Researchers will record brain activity and test memory in 70 volunteers who already have a brain device (RNS system). The goal is to understand which brain signals help us remember rou…

This study with 80 adults who have opioid use disorder and are starting buprenorphine aims to see if an MRI brain marker can predict who will successfully quit opioids. It also tests whether adding repetitive Transcranial Magnetic Stimulation (rTMS) helps people stay off opioids …

This study looks at blood samples from 50 people with blood cancers who are getting CAR T therapy. Researchers want to see how certain immune cells change over time and if those changes are linked to the cancer coming back or not responding. The goal is to learn more, not to test…

This study explores whether combining MRI and ultrasound images can help doctors guide brachytherapy (internal radiation) more precisely for uterine cancer. Researchers will take ultrasound images of the pelvis and try to fuse them with existing MRI scans. The goal is to see if t…