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Pee test could spot rare cancer earlier

NCT ID NCT06805630

First seen Nov 12, 2025 · Last updated Jun 20, 2026 · Updated 33 times

Summary

This study is testing whether a urine test that looks for DNA markers can help diagnose and monitor upper tract urothelial cancer (UTUC), a rare cancer of the kidney and ureter. Researchers will collect urine samples from 50 patients before surgery and during follow-up visits. The test results will be compared to standard methods like urine cell analysis and tissue biopsy to see if the new approach is accurate and useful.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Duke University

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Urine methylation biomarker test (Bladder CARE™)

What this could lead to

If successful, this urine test could offer a simpler, less invasive way to detect and monitor upper tract urothelial cancer, potentially catching recurrences earlier.

What could go wrong

This is a small, early-stage study with only 50 participants. The test may not prove accurate enough to replace current methods, and results may not apply to all patients.

Conditions

The condition(s) this trial relates to.

renal pelvis/ureter urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.