New study aims to improve drug dosing for sick kids
NCT ID NCT05055830
First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 34 times
Summary
This study looks at how certain drugs behave in the bodies of critically ill children under 21 in a heart intensive care unit. Researchers will collect leftover blood samples from routine care to measure drug levels. The goal is to better understand dosing and safety for drugs like methadone, caffeine, acetaminophen, and milrinone. No new drugs are given—just careful observation.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27705, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone, Caffeine, Acetaminophen, Milrinone
What this could lead to
If successful, this could lead to safer, more effective dosing guidelines for commonly used drugs in critically ill children.
What could go wrong
This is an observational study, not a treatment trial. It may not produce clear dosing recommendations, and results may not apply to all children.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.