OSTEOARTHRITIS KNEE

This study tested a new treatment for knee osteoarthritis using stem cells and a special liquid (secretome) from umbilical cord tissue. 31 patients aged 55-70 received the therapy either with or without a minor knee surgery (arthroscopy). The goal was to see if the stem cell comb…

This study tested an experimental drug called RHH646 in 82 adults with knee osteoarthritis. The goal was to see if it could help regrow cartilage in the knee and check for side effects. Participants received either the drug or a placebo, and researchers measured cartilage changes…

This study compared four types of knee replacements in 218 people with knee arthritis. The goal was to see which design helped patients 'forget' they had an artificial joint, meaning it felt more natural. Participants were randomly assigned to one of the four knee implants and fo…

This study tested a product called MegaCarti® to help regrow knee cartilage in people aged 50 to 65 with knee osteoarthritis. All 61 participants had a standard microfracture procedure, and some also received MegaCarti®. The main goal was to see if the cartilage looked better on …

This study tested a plastic meniscus implant in 115 people who still had knee pain after having part of their meniscus removed. The implant is designed to replace the damaged cushion in the knee and reduce pain. Researchers checked how safe the device was and whether it improved …

This early-stage study tested whether an experimental drug called CYT-108 is safe for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, and were monitored for 26 weeks. The main goal was to check…

This study looked at 192 people having knee replacement surgery for arthritis. It tested whether giving a drug called tranexamic acid into the knee joint could reduce blood loss and whether a surgical drain is still needed. The goal is to make surgery safer and recovery smoother.

This study tested two different rehabilitation programs for people with knee osteoarthritis. 71 participants with moderate to severe knee pain were randomly assigned to either an educational program alone or a combination of education and medical treatments. The goal was to see w…

This study tested whether adding a nerve block (adductor canal block) to a standard pain injection (local infiltration analgesia) reduces pain after knee replacement surgery better than the injection alone. Sixty-one adults having knee replacement took part. Researchers measured …

This study tested a procedure called Subchondroplasty (SCP) done with arthroscopy versus arthroscopy alone for people with knee pain from bone marrow lesions. About 131 adults aged 30-75 with mild to moderate knee osteoarthritis took part. The goal was to see if SCP plus arthrosc…

This study tested a procedure called cooled radiofrequency to treat chronic knee pain from osteoarthritis. It compared two sets of nerve targets to see which provides better pain relief and improves knee function. Ten adults with moderate to severe knee pain participated, and res…

This study tested whether injecting a patient's own processed fat tissue into the knee can reduce pain and improve function better than a standard steroid shot. 40 adults with moderate knee osteoarthritis took part. The goal was to see if this natural treatment offers longer-last…

This study looked at whether applying radial pressure wave therapy to specific spots on the knee works better than targeting the most painful areas for people with knee osteoarthritis. 82 adults with chronic knee pain and a diagnosis of knee osteoarthritis received three treatmen…

This study tested whether the OrthoCor Advanced System, which delivers heat and pulsed electromagnetic field (PEMF) therapy, can reduce pain and improve daily function in people with knee osteoarthritis. Twenty-three adults with knee pain for at least 3 months used the device for…

This study tested a medicated gel (diclofenac) applied once daily to the knee to relieve pain and stiffness from osteoarthritis. About 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain better than a place…

This study tested a technique called patellar denervation, where doctors use a heated tool to burn certain nerves around the kneecap during total knee replacement surgery. The goal was to see if this extra step reduces knee pain and improves function after surgery. The trial incl…

This study tested whether melatonin, a natural sleep hormone, can safely reduce pain in people with knee osteoarthritis. Researchers gave melatonin or a placebo to 340 adults aged 40-80 with moderate knee pain. The main goal was to see if melatonin improved pain scores on a stand…

This study tested a new interactive software that guides older adults with knee osteoarthritis through personalized exercises. The software uses wearable devices to give real-time feedback, helping patients perform movements correctly and safely. The goal was to improve joint mov…

This study looked at whether changing your diet and doing simple exercises can help reduce knee pain caused by osteoarthritis. 117 adults with knee pain for more than 3 months took part. They were split into groups: some changed their diet, some did exercises, some did both, and …

This study looked at whether using a smartphone app and Apple Watch for guided exercises and activity tracking could work as well as or better than standard physical therapy after hip or knee replacement. Over 6,500 adults who had joint replacement surgery took part. The main goa…

This study tested whether adding a special anti-inflammatory knee sleeve (Reparel™) to a standard corticosteroid injection improves pain, mobility, and daily function in people with knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were randomly assi…

This study looked at whether using a robot (MAKO) during total knee replacement helps people recover faster and have less pain compared to traditional surgery. 123 adults with knee osteoarthritis took part. Researchers measured pain scores and how well the new knee was aligned. T…

This study tested if combining a gentle brain stimulation technique (tDCS) with mindfulness exercises can help manage pain after knee replacement surgery. 24 adults who had knee replacement took part. The goal was to see if this approach is practical and might reduce the need for…

This study tested a new way to inject medicine into the knee for people with degenerative meniscus tears (a common cause of knee pain). The researchers compared injecting directly into the meniscus wall versus the standard injection into the joint space. 70 adults with knee osteo…

This study looked at 80 people with knee arthritis who had total knee replacement. It compared two ways to close the surgical wound: a skin adhesive (Dermabond) alone versus the same adhesive with a polyester mesh (Dermabond Prineo). The main goal was to see which method gave bet…

This study compared two different types of injections for knee osteoarthritis pain. One hundred adults with persistent knee pain received either a common steroid injection or an injection of an anti-inflammatory drug called tenoxicam. Researchers wanted to see which one provided …

This study followed 57 people with knee osteoarthritis for one year after they received an injection of NOLTREX™, a gel-like substance meant to replace joint fluid. The goal was to see if the treatment safely reduces pain, stiffness, and difficulty moving. Results focus on change…

This study tested a single injection of EVI-01 in 120 adults with painful knee osteoarthritis. Participants received one of two doses or a standard treatment to see which worked best for easing pain and stiffness. The goal was to find the safest and most effective dose for sympto…

This study tested whether hot compresses with black seed or ginger essential oils can reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee pain applied the oils daily for 7 days. The goal was to see if these natural oils offer ext…

This study looked at whether Baduanjin, a gentle mind-body exercise, can help people with knee osteoarthritis reduce pain, improve balance, and overcome fear of movement. Sixty adults aged 40 to 70 with knee OA were split into three groups: one did standard exercises, one added B…

This study looked at how video-guided acupuncture imagery changes brain activity in people with knee osteoarthritis. 125 participants had brain scans before and after treatment to understand the mind-body connection. The goal was to learn more about how imagery and acupuncture wo…

This study analyzed data from 62 people with knee osteoarthritis who received radial pressure wave therapy. Researchers looked at factors like age, weight, and pain levels to see which patients had the best improvement after six months. The goal is to help doctors predict who wil…

This study looked at how pain in one knee changes the way people walk, especially the forces on the other knee. Researchers studied 55 adults with knee osteoarthritis and healthy volunteers. Participants walked on a treadmill and received knee injections to help measure joint loa…

This pilot study looked at factors that might predict pain and function after total knee replacement surgery. Researchers tested a brief mindfulness-based therapy in a small group of patients and compared them to those receiving usual care. The goal was to gather initial data on …

This study looked at how walking for 30 minutes affects the risk of tripping and falling in adults aged 55-70 with and without knee osteoarthritis. Participants completed questionnaires, wore an activity tracker, and did strength and balance tests before and after a treadmill wal…

This study looked at 45 postmenopausal women with knee osteoarthritis who needed knee replacement surgery. Researchers compared fat from bone marrow with fat from under the skin to see which one releases more harmful substances that damage joints. The goal is to find new ways to …

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at how different types of shoe insoles affect knee movement and quality of life in people with knee osteoarthritis. 30 participants were tested to see if insoles change how the knee works during walking and if any benefits are linked to those mechanical changes.…

This study looked at how the space in the knee joint changes when people with knee osteoarthritis stand or bend their knees. Researchers used MRI scans in different positions to better understand these changes. The goal was to help compare measurements taken in different ways. 21…