OSTEOARTHRITIS KNEE

This study tested a drug called lorecivivint for people with knee osteoarthritis over two years. It included 276 adults who had already been in a previous study. The goal was to see if the drug could safely reduce pain and improve knee function. The trial was stopped early, so re…

This study looked at whether bariatric surgery or medical weight loss is better at helping severely obese patients lose enough weight to safely have hip or knee replacement surgery. The goal was to get patients to a body mass index (BMI) of 40 or lower. The study was stopped earl…

This study tested an experimental drug called GSK3858279 in 314 adults with moderate to severe knee osteoarthritis pain. The goal was to find the safest and most effective dose to reduce pain. The study was terminated early, but results may still help guide future research.

This study tested an experimental drug called QUC398 in 101 people with painful knee osteoarthritis. The goal was to see if it could reduce pain and protect knee cartilage. The trial was stopped early, so results are limited.

This study tested a temporary device that stimulates nerves around the knee to relieve chronic pain from osteoarthritis. Twelve adults with knee pain received the treatment, and researchers measured changes in pain intensity and quality of life. The goal was to see if this non-su…

This study looked at different X-ray methods and MRI to see which best shows cartilage loss in arthritic knees. Researchers aimed to help doctors decide if patients need partial or full knee replacement. The study was stopped early with only 8 participants, so results are limited…

This study looked at whether oxytocin, a natural hormone, can reduce pain when given through an IV. It included 7 people—some healthy and some with severe knee arthritis. Researchers measured pain from a heated skin patch to see how oxytocin changes pain perception.