OSTEOARTHRITIS, KNEE

This study is comparing two different plastic inserts used in total knee replacement surgery. One insert has Vitamin E added to it, while the other is a standard version. Researchers are following 605 patients for many years to see if the Vitamin E insert leads to better long-ter…

This study is testing the safety and performance of a specific knee replacement system called JOURNEY II CR. It involves 170 people with severe knee arthritis who need a total knee replacement. Researchers will follow participants for up to 10 years after surgery to see how well …

This study aims to compare a newer knee replacement implant (Persona) with a well-established older model (NexGen) in patients with severe knee arthritis. Researchers will track 185 patients for up to 10 years to see which implant provides better stability, function, and satisfac…

This study is following people for five years after they received an experimental treatment or a placebo for knee osteoarthritis. The main goal is to check for any long-term safety issues and see if the treatment's effects on pain and knee function last over time. It is only for …

This study is testing whether injections of Allocetra, a cell-based therapy, can help control knee osteoarthritis by reducing pain and improving joint function. The trial involves 160 adults with moderate to severe knee arthritis who haven't gotten enough relief from standard tre…

This study compares two surgeries for arthritis that only affects the area under the kneecap. One surgery replaces just the kneecap joint, while the other replaces the entire knee. Researchers are measuring which one helps patients move better, feel less pain, and lasts longer ov…

This early-stage study is testing the safety and initial effectiveness of an experimental injection called ANT-301 for people with moderate to severe knee osteoarthritis. Six participants with significant knee pain will receive the injection to see if it's safe and if it helps re…

This study aims to find out which type of partial knee replacement implant stays fixed in the bone better over time: one that uses surgical cement or one that doesn't. It will follow 70 patients with severe arthritis in just one part of their knee for up to 5 years after surgery.…

This study is testing if a single steroid injection given during a common knee surgery can reduce joint inflammation and slow the progression of arthritis. It will involve 150 patients aged 40 and older who are having surgery for a torn meniscus. Researchers will measure pain lev…

This study tests whether adding Virtual Reality (VR) therapy or guided relaxation exercises to standard rehab helps older adults recover better after hip or knee replacement surgery. Researchers are comparing these two methods to see which is more effective at reducing stress and…

This study is testing if giving a common steroid (hydrocortisone) through an IV after knee replacement surgery helps patients regain better knee movement and feel less pain. It involves 132 adults getting a single knee replacement who will receive either the steroid or a placebo …

This study is testing a coaching program called 'Moving Well' to see if it helps people feel less anxious and depressed before and after total knee replacement surgery. People scheduled for the surgery will work with a coach who has already had the procedure themselves. The main …

This study is testing whether adding a specific type of therapy for insomnia (CBT-I) to standard knee osteoarthritis care helps patients more than standard care alone. It involves 128 adults aged 45+ who have both knee arthritis and chronic insomnia. The main goal is to see if th…

This study is testing a special pillow called the Zero Degree Knee positioner. It's designed to help people recover better at home after total knee replacement surgery. The research will compare patients using the pillow to those following standard recovery instructions to see if…

This small pilot study aims to see if the pain medication naproxen helps people with painful knee osteoarthritis feel better. Twenty participants will try both naproxen and a placebo pill in a random order over several weeks, with breaks in between. Researchers will track daily p…

This study aimed to see if teaching runners with knee osteoarthritis a different running style could reduce their pain and lower stress on their knee joints. It planned to enroll runners with mild-to-moderate arthritis for a 4-week training program to modify their gait. The goal …

This study is testing a minimally invasive procedure called genicular radiofrequency ablation (GRFA) for people who still have significant knee pain more than a year after a total knee replacement. It compares the real procedure to a sham (fake) one to see if it safely reduces pa…

This study is testing whether a dietary supplement, exercise, or a combination of both is most effective for managing knee osteoarthritis. It involves 93 adults with knee pain who will take either a real supplement, a placebo, and/or do supervised exercises for 12 weeks. Research…

This study is testing whether a daily gel called AMZ001 can safely reduce pain and other symptoms of knee osteoarthritis. About 540 adults with moderate knee arthritis will apply the gel or a placebo to one knee for six weeks. Researchers will measure changes in pain levels to se…

This study investigates whether seeing the preparation steps for a platelet-rich plasma (PRP) knee injection influences how well patients think it works for osteoarthritis pain. Researchers are testing if patients who watch the injection being prepared report better pain relief a…

This study aims to understand why some people develop knee arthritis years after ACL reconstruction surgery. Researchers will perform detailed MRI scans on 219 people approximately 10 years after their surgery to examine their knee cartilage. The goal is to gather knowledge that …