OSTEOARTHRITIS KNEE

This study looks at whether a steroid injection given right after knee surgery can help reduce pain and inflammation in people with osteoarthritis and meniscus tears. About 150 adults aged 40 and older will receive either the injection or a placebo. The goal is to see if the inje…

This study compares two types of plastic used in total knee replacements: one with vitamin E and one without. About 605 adults with knee arthritis or similar conditions will be followed for years to see which material lasts longer and leads to better knee function. The goal is to…

This study tests a once-weekly injection called retatrutide for weight loss in people with obesity or overweight who do not have diabetes. About 2,335 participants will receive the drug or a placebo for up to 89 weeks. The study also looks at how the drug affects knee osteoarthri…

This study looks at two types of knee implants for people with severe knee arthritis. One type uses cement to hold the implant in place, the other does not. The goal is to see which implant stays fixed better over 5 years. About 70 people will take part.

This study compares two types of knee implants (NexGen CR and Persona CR) in 185 people with knee osteoarthritis. Participants will receive one of the implants and be followed for several years using X-rays, activity monitors, and questionnaires to measure satisfaction, function,…

This study follows 16 people who previously received the experimental drug ICM-203 or a placebo for knee osteoarthritis. Researchers will track any delayed side effects and measure changes in knee pain and function over time. The goal is to understand the long-term safety and eff…

This early-stage study tested a new treatment called ANT-301 in 6 people with severe knee osteoarthritis. The main goal was to check if the treatment is safe and to see if it helps reduce pain and improve knee function. The study is now complete and results are being analyzed.

This study aimed to see if a 4-week running gait retraining program could reduce knee pain and improve function in runners with mild to moderate knee osteoarthritis. Participants would have been adults who run at least 10 km per week and have knee pain. However, the study was wit…

This study tests a behavioral program called Moving Well for people waiting for knee replacement surgery. The goal is to see if it can lower anxiety and depression before the operation. About 79 adults aged 50 and older who speak English and have internet access are taking part. …

This study compares two types of knee surgery for people with arthritis only behind the kneecap. One surgery replaces just the kneecap area, while the other replaces the whole knee joint. Researchers will track 100 participants for up to 10 years to see which surgery leads to bet…

This study looks at whether adding cognitive behavioral therapy for insomnia (CBT-I) to standard knee osteoarthritis care (education and exercise) helps reduce pain and improve quality of life more than standard care alone. About 128 adults aged 45 and older with both knee osteoa…

This study tests a procedure called genicular radiofrequency ablation (GRFA) for people who still have knee pain more than a year after knee replacement surgery. The treatment uses heat to calm the nerves around the knee. 44 participants will be randomly assigned to receive eithe…

This study compares a single injection of hyaluronic acid to a series of three injections for treating knee osteoarthritis. Researchers want to see if the single shot works just as well for pain relief and knee function, while being more convenient. The study involves 46 adults a…

This study tests whether a disposable device called the Zero Degree Knee positioner helps people regain full knee extension faster after total knee replacement surgery. About 154 adults aged 40-80 with knee osteoarthritis will be randomly assigned to use the device or follow stan…

This study looks at whether nonsteroidal anti-inflammatory drugs (NSAIDs) can help reduce pain in people with knee osteoarthritis. About 20 adults over age 40 with moderate to severe knee pain will take NSAIDs in a carefully designed crossover pattern. Participants will rate thei…

This study looks at whether adding a dietary supplement to an exercise program helps people with knee osteoarthritis feel less pain and move better. About 93 adults with mild to moderate knee osteoarthritis will be split into three groups: supplement alone, supplement plus exerci…

This study looks at whether virtual reality therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these metho…

This study looks at whether adding a gentle electrical current (interferential current) to a standard exercise program can reduce pain and improve daily function in people with knee osteoarthritis. About 138 adults aged 40 to 75 with knee pain for over 3 months will be randomly a…

This study tests a new medicine called Allocetra, given as a shot into the knee, to see if it safely reduces pain and improves function in people with knee osteoarthritis. About 160 adults aged 45 to 80 with chronic knee pain that hasn't responded to standard treatments will rece…

This study tests whether remote exercise sessions (telerehabilitation) can improve function and reduce symptoms in people with hip or knee osteoarthritis. About 110 participants will be split into two groups: one gets patient education, the other gets guided exercise sessions fro…

This study looks at whether watching the steps to prepare a platelet-rich plasma (PRP) injection for knee osteoarthritis can make the treatment feel more effective. About 158 adults aged 50-80 with knee osteoarthritis will receive the injection, and some will observe the preparat…

This study looks at whether taking a short course of oral methylprednisolone (a steroid) after knee replacement surgery can help reduce pain, the need for strong painkillers, and nausea. About 116 adults with knee osteoarthritis who are having a first-time knee replacement will t…

This study looks at whether blocking certain arteries in the knee with tiny particles (embolization) can reduce pain and the need for painkillers in people with knee osteoarthritis. Twelve adults with mild to moderate knee arthritis will get the procedure and be followed for a ye…

This study looks at how well a new knee replacement system (JOURNEY™ II CR) works for people with severe knee arthritis. About 170 adults aged 22 to 75 who need a knee replacement will get the new implant. Researchers will check if it improves knee movement and holds up well over…

This study looked at 62 people having knee replacement surgery to see if a J-shaped cut (instead of the usual straight cut) reduces numbness and pain around the scar. The J-shaped cut curves at the bottom to avoid a nerve that often gets hurt. Researchers measured numbness and pa…

This study looks at whether giving the steroid hydrocortisone through a vein can improve how much people can bend and straighten their new knee after total knee replacement surgery. About 132 adults with knee arthritis who are having their first knee replacement will take part. S…

This study uses advanced MRI scans to see how knee cartilage is doing 10 years after ACL reconstruction surgery. Researchers will compare the repaired knee to the healthy knee in 219 adults who had an ACL tear from sports. The goal is to learn more about why some people develop p…

This study looks at three different ways to close surgical wounds after hip or knee replacement surgery. About 600 patients will be randomly assigned to one of three products: Sylke adhesive dressing, Exofin skin glue, or Suture Strip Plus. The goal is to see which method causes …