OSTEOARTHRITIS KNEE

This study is testing a knee implant called Persona in 760 people who need knee replacement surgery due to arthritis or other knee problems. The goal is to see if the implant is safe, works well, and helps patients move better and feel less pain. Participants will be followed for…

This early-stage study tests a single injection of cells made from donated gum tissue into the knee joint of 15 people with knee osteoarthritis. The main goal is to check safety, but researchers will also look at pain and function. The cells showed promise in animals for reducing…

This study tests whether a comprehensive medical treatment plan can work as well as knee replacement surgery for people with knee osteoarthritis. Researchers will compare pain and function in 1000 adults who either receive intensive medical care or undergo surgery. The goal is to…

This study tests whether stem cells from umbilical cords can safely help people with knee osteoarthritis. About 60 adults with moderate knee damage will receive the cells and be monitored with MRI scans and pain scores. The goal is to see if the treatment can repair cartilage and…

This study tests whether tiny particles called exosomes, taken from donated stem cells, can help people with knee osteoarthritis. The goal is to reduce pain and improve knee function. Twenty adults with mild to moderate knee arthritis will receive the treatment and be monitored u…

This study is testing a new computer guidance system (software) used during total knee replacement surgery. The goal is to see if the new software helps surgeons place the artificial knee joint more accurately than the older system. About 120 adults who need a knee replacement wi…

This study compares knee realignment surgery alone versus realignment plus a donor meniscus transplant in 52 adults aged 20-60 with knee osteoarthritis and a missing meniscus. The goal is to see if the combined approach provides better pain relief, function, and joint protection.…

This study tests if a smartphone app can measure how well your knee moves during daily activities like walking or standing up. The goal is to catch knee osteoarthritis early, when treatments work better. About 47 veterans with early knee arthritis will use the app, and results wi…

This study tests whether taking a supplement called GlyNAC (glycine and N-acetyl-cysteine) before and after knee replacement surgery can reduce oxidative stress and prevent chronic pain. About 148 adults aged 50+ with knee osteoarthritis will be followed for 12 months. The goal i…

This study tests whether adding probiotic supplements to usual care can reduce pain, stiffness, and improve physical function in people with knee osteoarthritis. About 146 adults with knee OA will take probiotics or a placebo alongside their standard treatment. The goal is to see…

This study looks at whether low-impact group exercise classes, combined with standard dietitian and behavioral health visits, can lower pain scores in adults with knee, hip, or ankle osteoarthritis. About 10,000 participants aged 18 and older will attend classes three times a wee…

This study tests whether nurse-led telehealth visits using a mobile app can detect complications and support recovery after total knee replacement just as well as traditional in-person clinic visits. About 98 adults who had their first knee replacement will be randomly assigned t…

This study compares two types of knee replacement surgery: the standard method and a newer robotic-assisted technique. Researchers want to see if the robotic approach leads to better pain relief, movement, and implant placement. About 86 adults aged 40 to 85 with severe knee arth…

This study tests a program to help Hispanics with knee osteoarthritis become more active. Participants pair up with a family member or close friend and receive live video sessions on exercise and education. The goal is to see if this approach improves symptoms and physical activi…

This study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or have obesity and also suffer from knee osteoarthritis. The goal is to see if the drug helps with weight loss and reduces knee pain compared to a placebo. Participants are randomly ass…

This study tests whether adding game-like rewards, social support, and health coaching can help people with knee osteoarthritis stick to their physical therapy exercises and stay active. 254 veterans will be followed for 2 years to see if these approaches improve pain, function, …

This study tests a walking program that uses a short course of anti-inflammatory pain medication to help people with painful hip or knee osteoarthritis walk more. The goal is to see if taking the medication only around planned walks can improve walking ability without causing sid…

This study tests if an injected drug called pentosan polysulfate sodium can reduce pain and improve function in people with knee osteoarthritis. About 466 adults with knee pain that hasn't responded to other treatments will receive either the drug or a placebo over 6 weeks. Resea…

This study looks at whether adding a special pain education program to standard exercises can improve daily function for people with knee osteoarthritis. About 92 adults with knee OA will be split into two groups: one doing only exercises, the other doing exercises plus pain neur…

This study is testing whether taking cannabidiol (CBD) before and after knee replacement surgery can lower the amount of opioid painkillers people need. Researchers will track pain, inflammation, and side effects in 380 adults with knee osteoarthritis. The goal is to find a safer…

This study looks at whether injecting the anti-inflammatory drug dexamethasone into a nerve block or into a vein works better for pain and swelling after total knee replacement. About 90 adults having knee surgery will be randomly assigned to one of the two methods. Researchers w…

This study tests whether helping people sleep better for 4 weeks before knee or hip replacement surgery can reduce pain and speed recovery afterward. About 100 adults with insomnia and osteoarthritis will receive either a brief sleep therapy (CBT-I) or sleep education before thei…

This study compares two types of computer-assisted knee replacement surgery: one using a navigation system and the other using a robotic arm. The goal is to see if both methods provide similar results in terms of pain relief, function, and safety. About 140 adults with knee arthr…

This study compares a new device called the MISHA Knee System to non-surgical treatments for people with knee osteoarthritis that hasn't improved with other therapies. About 100 adults with pain on the inner side of the knee will be randomly assigned to receive either the implant…

This study is testing whether daily doses of CBD, THC, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 adults with moderate to severe knee pain for at least six months will take one of the study drugs or a placebo for 16 weeks. Researche…

This study tests if people with knee osteoarthritis can learn to change how they use a calf muscle while walking, using a device that gives a buzz or vibration as feedback. The goal is to reduce the force on the knee joint, which may ease pain and slow joint damage. About 31 part…

This study is testing several experimental treatments to ease chronic pain from knee arthritis, diabetic nerve pain, or ongoing low-back pain. Researchers will compare each treatment against a placebo to see which ones work best. The trial aims to enroll 10,000 adults who have ha…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study is testing whether cannabidiol (CBD) placed under the tongue can safely reduce knee pain from osteoarthritis and help people use fewer over-the-counter pain relievers like ibuprofen. Researchers will enroll 30 adults with moderate to severe knee pain. The goal is to se…

This study tests whether injections made from a person's own bone marrow or fat cells can reduce knee pain from osteoarthritis better than a placebo. About 148 adults with moderate knee arthritis will receive one of these cell injections or a dummy shot. Researchers will track pa…

This study looks at two different methods of placing a total knee prosthesis: the standard mechanical alignment and a newer, more personalized kinematic alignment. The goal is to see which technique leads to better knee movement and function when walking or climbing stairs. Resea…

This study looks at different ways to close the wound after hip or knee replacement surgery. About 90 adults having these surgeries will be randomly assigned to one of two closure methods. The goal is to see which method leads to better wound healing, fewer complications like inf…

This study looks at how oxytocin, a natural hormone, affects the part of the nervous system that controls rest and digestion. Researchers will measure changes in pupil size after an injection of oxytocin or a placebo. The goal is to understand how the body responds to pain, not t…