OSTEOARTHRITIS, KNEE

This pilot study is testing whether a minimally invasive procedure called geniculate artery embolization can help control pain and slow arthritis progression in the knee. Twenty adults with mild to moderate knee osteoarthritis will be randomly assigned to receive either the embol…

This study is testing whether tiny particles released by stem cells (called exosomes) can help people with knee osteoarthritis. Researchers will inject these particles into the knees of 20 participants with mild to moderate arthritis to see if they reduce pain and improve joint f…

This is the first study in people to test the safety of a single injection of specially engineered cells, made from human gum tissue, directly into the knee joint of patients with osteoarthritis. The goal is to see if this cell therapy is safe and to gather early signs of whether…

This study aims to compare two advanced technologies used in total knee replacement surgery: robotic-assisted and computer-navigated systems. It will involve 140 patients with severe knee arthritis to see if one method leads to better function, less pain, or a higher quality of l…

This large research program is testing several different experimental treatments for chronic pain conditions including knee arthritis, low back pain, and diabetic nerve pain. The study will enroll up to 10,000 participants to compare new pain interventions against placebo treatme…

This study is testing whether injections of stem cells from donated umbilical cords can help people with knee osteoarthritis. Researchers want to see if the treatment is safe and if it can reduce pain and improve knee function. They will track 60 participants for a year after tre…

This study is testing if a remote support program can help people stick with their knee exercises after finishing physical therapy for osteoarthritis. The program uses game-like challenges, social support, and optional health coaching delivered through a smartphone app. Researche…

This study is testing whether a combined surgical approach works better than standard surgery alone for certain knee problems. It involves patients aged 20-60 with knee arthritis, poor leg alignment, and a missing meniscus (a knee cushion). Half will get a surgery to realign the …

This study aims to find the best way to close the surgical wound after a hip or knee replacement. Researchers will compare two different stitching materials and techniques in 90 patients to see which one leads to better healing, fewer infections, and better recovery. The goal is …

This study is testing whether people with knee osteoarthritis can learn to walk differently using haptic feedback—gentle vibrations that guide muscle use. Researchers want to see if changing how a specific calf muscle works during walking can reduce stress on the knee joint. The …

This trial is testing whether injections made from a patient's own bone marrow or processed fat tissue can help control knee osteoarthritis better than a placebo injection. About 148 adults with moderate knee pain and arthritis will receive one of the two experimental treatments …

This study is testing new computer software designed to help surgeons perform knee replacement operations more accurately. It will involve 120 adults with severe knee arthritis who need a total knee replacement. Researchers will compare the new software to the previous version by…

This study is testing whether follow-up care via video calls with a nurse is as good as traditional in-person visits for people recovering from knee replacement surgery. It will enroll 98 adults who have just had their first knee replacement. The main goal is to see if video call…

This study is testing whether antioxidant supplements given around the time of knee replacement surgery can prevent long-term chronic pain. Researchers will enroll 148 adults aged 50+ with osteoarthritis who are scheduled for knee replacement. Participants will receive either the…

This study is testing whether a medication called pentosan polysulfate sodium (PPS), given as an injection under the skin, can reduce pain and improve movement in people with painful knee osteoarthritis. About 466 adults will receive either the PPS injections or placebo (inactive…

This study is testing a new program designed to help Hispanic adults with knee osteoarthritis become more active and manage their pain. Participants, along with a chosen family member or friend, will join video sessions to learn about the condition and follow a tailored exercise …

This study is evaluating the safety and benefits of Persona knee replacement implants for people with severe knee arthritis or joint damage. Researchers will follow 760 patients for up to 10 years after surgery to measure pain reduction, mobility improvement, and overall satisfac…

This study is comparing two ways to perform total knee replacement surgery for severe arthritis: the standard manual method and a newer robot-assisted technique. Researchers want to see if using a robot helps patients recover better, with less pain and improved knee function. The…

This study is testing if a daily dose of cannabidiol (CBD) can help people use fewer opioid painkillers after knee replacement surgery. Researchers will give 380 participants either CBD or a placebo pill before and after their operation to see if it reduces pain, inflammation, an…

This study is testing whether giving a common steroid medicine directly into a nerve block is better at reducing pain and swelling after knee replacement surgery than giving the same medicine through an IV. Researchers will compare the two methods in 90 patients aged 65-100 who a…

This study is testing whether adding probiotic supplements to standard osteoarthritis care can help reduce pain, stiffness, and improve daily function. Researchers are enrolling 146 adults with knee osteoarthritis to compare probiotics plus standard care against standard care alo…

This study is testing whether a new implant called the MISHA Knee System works better than standard non-surgical treatments for reducing pain and improving movement in people with knee arthritis. About 100 participants with ongoing knee pain who haven't gotten relief from other t…

This study tests a walking program designed to help people with painful hip or knee osteoarthritis become more active. Participants take common anti-inflammatory pain medication only before planned walks, combined with proper footwear and education, to reduce pain during movement…

This study aims to understand if daily treatment with THC, CBD, or a combination can help reduce pain and other symptoms in people with knee osteoarthritis. Researchers will enroll 200 participants to test how these compounds affect brain activity and inflammation over a 16-week …

This study is testing whether a liquid form of CBD (cannabidiol) placed under the tongue is safe and can help reduce pain and improve daily function for people with knee osteoarthritis. Researchers will compare the effects of CBD to a placebo (inactive substance) in 30 adults wit…

This study is testing whether a program of low-impact group exercise, combined with diet advice and mental health support, can help reduce pain for people with osteoarthritis in their knees, hips, or ankles. It will enroll up to 10,000 adults who can commit to attending classes t…

This study aims to understand if a hormone called oxytocin affects a specific type of pupil movement (hippus) as a way to measure brain activity. Researchers will compare healthy volunteers to people with chronic knee pain from arthritis. Participants receive either oxytocin or a…