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Gut health may soothe aching knees: new trial tests probiotics for arthritis relief

NCT ID NCT07364578

Symptom relief Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study tests whether adding probiotic supplements to standard treatment can reduce pain, stiffness, and improve daily function in people with knee osteoarthritis. About 146 adults with symptomatic knee OA will take probiotics or a placebo for a set period. The goal is to see if this simple addition offers meaningful symptom relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

146 people

The number who actually took part.

Started

Feb 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients (both sexes) aged above 18 years who met the American College of Rheumatology (ACR) clinical criteria for KOA \[7\] and had symptomatic OA of at least one knee (index knee). Exclusion Criteria: 1. Rheumatoid arthritis or other active generalized inflammatory comorbidities affecting the gastrointestinal tract (IBD, celiac disease) 2. Performed a total knee replacement on the affected knee or the waiting list for joint replacement 3. surgeries (such as gastric bypass) or Other concomitant injuries can override OA symptoms or interfere with physical activity. 4. Malabsorption disorders, systemic organ failure (liver, renal, cardiac) 5. Use corticosteroids with doses above 10 mg/day or Intra-articular injections during the previous 6 months. 6. Recent antibiotic treatment (i.e., \<2 months before the beginning of the study). 7. Pregnancy/breastfeeding 8. Participants who smoked more than 10 cigarettes per day were excluded. 9. Immunosuppressive treatment or impaired immune system 10. Chronic or acute diarrhea 11. Blood/plasma donation/transfusion during the 3 months of the study 12. Non-controlled diabetes 13. Allergy with regards to any of the study product ingredients. 14. Post-traumatic OA (e.g., fractures), congenital hip deformities, or degenerative or non-degenerative neurological conditions can alter pain perception.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

Contacts and locations

Locations

  • Asmaa Abdelfattah Elsayed

    Banī Suwayf, 82511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.