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Knee pain relief: supplement and exercise combo tested

NCT ID NCT06269549

Symptom relief Sponsor: University of Primorska Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding a dietary supplement to an exercise program can reduce pain and improve movement in people with knee osteoarthritis. About 93 adults with mild to moderate knee arthritis will be split into three groups: supplement alone, supplement plus exercise, or placebo plus exercise. Researchers will compare the groups to see if the combination works better than either alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 93 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * knee osteoarthritis of one or both knee * severity of knee osteoarthritis based on Kellgren-Lawrence radiographic grade 1-3 * knee pain between 4 and 7 (using a 0-10 scale) Exclusion Criteria: * Age \<55 years * Kellgren \& Lawrence grade 4 of knee osteoarthritis * Acute knee injuries within the last 6 months * Knee pain not associated with knee osteoarthritis * History of knee or hip endoprosthesis * Surgery on the back, hip, knee, ankle, or foot within the last 12 months * Health issues or musculoskeletal limitations affecting strength training and mobility more than knee pain (e.g., lower back pain, hip pain) * Rheumatoid arthritis, gout * Neurological conditions (Alzheimer's disease, Parkinson's disease, metabolic diseases affecting the nervous system) * Muscular or joint diseases/injuries affecting lower limb function (e.g., hip and/or ankle osteoarthritis, sprains, fractures) * Internal medical conditions (cardiovascular, pulmonary, oncological, diabetes with late complications - diabetic foot, neuropathies) affecting physical performance * Stroke or similar condition with consequences on motor skills and/or cognition (inability to provide consent) * Balance disorders, known vestibular system impairment * Body Mass Index \> 32 * Structured strength training exceeding 30 minutes per week * Corticosteroids and/or hyaluronic acid (intra-articular) use in the last 6 months * Individuals taking joint health dietary supplements, like glucosamine, chondroitin, or collagen, will need to halt use for at least 30 days before measurements to avoid affecting study outcomes

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Conditions

The condition(s) this trial relates to.

Motor Activity osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

Contacts and locations

Locations

  • Community Healthcare Center dr. Adolf Drolc

    Maribor, 2000, Slovenia

  • University of Primorska, Faculty of Health Sciences

    Izola, 6310, Slovenia

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