Could one knee injection replace three? new trial tests simpler treatment
NCT ID NCT07352540
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a single large injection of hyaluronic acid to three smaller weekly injections for knee osteoarthritis. Researchers want to see if the one-shot approach is as safe and effective at reducing pain and improving knee function. The trial involves 46 adults aged 40-70 with moderate to severe knee osteoarthritis.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hyaluronic acid (HA) injection
- What this could lead to
- If the single injection works as well as three, it could offer a simpler, more convenient treatment option for knee osteoarthritis.
- What could go wrong
- This is a small, early-phase study with only 46 participants. The single injection may not provide the same pain relief as the triple regimen, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
About 46 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jan 2026
- Expected to finish
-
Sep 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 40-70 years * Radiographically confirmed moderate to severe knee osteoarthritis * Knee pain for ≥3 months * Pain on ≥50% of days in past 30 days * Able to provide informed consent Exclusion Criteria: * Grade 4 osteoarthritis (full-thickness cartilage loss) * Non-osteoarthritic knee pain * Other rheumatic diseases (e.g., rheumatoid arthritis, fibromyalgia) * HA injection \<6 months or corticosteroid injection \<3 months in target knee * Recent trauma or surgery of affected knee (\<6 months) * Coagulopathy or bleeding disorder * Autoimmune or relevant systemic disease * Dermatologic infection at injection site * Pregnancy or lactation * Opioid or oral corticosteroid use * Contraindications to MRI (pacemaker, intracorporeal metal, claustrophobia) * Expected absence during study period or noncompliance
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Osteoarthritis, knee are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institute of Radiology, University Hospital Erlangen
Erlangen, 91052, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Which anesthesia gets joint replacement patients moving sooner?
- Can a special MRI match CT for spotting knee bone damage?
- Can a common bleeding drug make knee realignment surgery safer?
- One shot, new knee? gene therapy trial aims to quiet arthritis pain
- Three knee shots go Head-to-Head for lasting arthritis relief
- Gel shot vs standard injection: which quiets arthritic knees?