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Knee pain relief: synthetic fluid injection shows promise in Long-Term study

NCT ID NCT06523491

Symptom relief Sponsor: Research Centre BIOFORM Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study followed 57 people with knee osteoarthritis for one year after they received an injection of NOLTREX™, a synthetic joint fluid. Researchers measured changes in pain, stiffness, and physical function using a standard questionnaire. The goal was to see if the injection provides lasting relief and is safe over the long term.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NOLTREX™ (a synthetic joint fluid injection)
What this could lead to
If successful, this could provide a long-lasting option to ease pain and improve knee function in people with moderate knee osteoarthritis.
What could go wrong
This is a small, completed study with only 57 participants. The results are based on survey data, not a new treatment trial, so benefits may not be as strong in larger, more diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

57 people

The number who actually took part.

Started

May 2022

Finished

May 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study included 57 patients divided into 3 subgroups based on treatment received: * Group NOLTREX™ 2 courses - 30 patients (52.63%) * Group NOLTREX™ 1 course - 17 patients (29.82%) * Placebo group - 10 patients (17.54%)

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: The study included patients with KL grade 2-3 knee osteoarthritis who had completed study IA/PAAG-SI/OA/2019 and IA/PAAG-SI/OA/2020. Exclusion criteria: Declining participation in the survey Lost to follow-up

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

Contacts and locations

Locations

  • Private Healthcare Facilty "Clinical hospital "RZHD-Medicina" of the city Saint-Petersburg

    Saint Petersburg, Russia

  • State budgetary healthcare facility of Yaroslavl Region "Clinical hospital №3"

    Yaroslavl, Russia

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Other studies related to the condition(s) this trial covers.