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New combo treatment aims to ease knee pain without surgery

NCT ID NCT05286775

Symptom relief Sponsor: Marta Imamura Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed trial tested whether adding medical treatments (lidocaine injections and shockwave therapy) to a knee education program could better reduce pain and improve function in people with knee osteoarthritis. 71 participants with moderate to severe knee pain were randomly assigned to either the education program alone or the education program plus the medical treatments. The study measured changes in knee function and pain at the end of treatment and three months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine and shockwave therapy
What this could lead to
If successful, this approach could offer a non-surgical option to reduce pain and improve knee function in people with knee osteoarthritis.
What could go wrong
This is a small, completed trial with only 71 participants, so results may not apply to everyone. The treatments are short-term and may not provide lasting relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

71 people

The number who actually took part.

Started

Mar 2022

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of knee osteoarthritis; * Moderate to severe knee pain (VAS \>= 4); * Knee pain for at least 3 months prior to inclusion; * Willing to sign the Informed Consent Form. Exclusion Criteria: * Untreated severe psychological or psychiatric diseases without treatment; * Presence of fibromyalgia; * Presence of systemic inflammatory rheumatic diseases; * Presence of neoplasia; * Presence of relevant pain in other joints, according to medical evaluation; * Presence of intolerance or allergy to Lidocaine or local anaesthetics; * Concomitant use of anticoagulant drug.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

Contacts and locations

Locations

  • Instituto de Medicina Física e Reabilitação (IMREA-FMUSP)

    São Paulo, São Paulo, 04101-300, Brazil

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