CHRONIC KIDNEY DISEASES

This study looked at whether taking a prebiotic fiber (resistant starch) and doing moderate aerobic exercise for 16 weeks could reduce inflammation and improve blood vessel health, thinking, and mood in people with stage 3-4 chronic kidney disease. 68 patients were randomly assig…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This pilot study tested whether using central blood pressure (measured near the heart) instead of the standard arm cuff helps manage hypertension in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central or brachial blood pressure…

This study tested whether baricitinib, a drug used for arthritis, can safely reduce high protein levels in the urine of African American adults with a specific genetic form of kidney disease (APOL1). Eight participants took the drug to see if it lowered their urine protein and pr…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested a new dialysis filter (ELISIO-HX) in 22 adults with kidney failure to see if it was safe and worked well. The main goal was to make sure the filter did not lower albumin levels (a key protein in the blood) while also improving removal of certain waste products. …

This early-stage study tested a new treatment made from a patient's own urine-derived stem cells for chronic kidney disease. Six adults with moderate to severe kidney disease received the treatment to check its safety and how well it might work. The main goal was to see if the tr…

This study tested a device that creates a connection between an artery and a vein in the arm to make dialysis easier for people with kidney failure. Thirty-two adults with chronic kidney disease who needed dialysis took part. The main goals were to see if the connection worked we…

This study looked at 108 people with early chronic kidney disease (CKD), high blood pressure, and a condition called metabolic acidosis. Researchers compared eating more fruits and vegetables versus taking sodium bicarbonate (baking soda) pills to see if either could slow kidney …

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs, like food and housing, while also providing lifestyle coaching. Fifty participants received one-on-one sessions and a device to track blood sugar and blood pres…

This study tested whether a low dose of the blood thinner rivaroxaban (Xarelto) could reduce major heart problems in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to take either the drug or a placebo. Th…

This study tested a new drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose blood pressure was still high despite treatment. Participants took either a low or high dose of the drug or a placebo daily for 84 days. The main goal was to see if the…

This study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo by injection. The results will …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a new device that creates a connection between an artery and a vein in the arm for dialysis. It involved 24 adults with kidney failure who need dialysis. The goal was to see if the device works and to explore a new way to access blood vessels for treatment.

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease improve their blood pressure. 320 adults with moderate to severe kidney disease and uncontrolled high blood pressure took part. The goal was to see if the coachin…

This study looked at how different types of exercise affect bone health in people with chronic kidney disease. Sixty patients did either aerobic or resistance exercises for 6 months. Researchers measured bone turnover markers and bone density before and after the program to see w…

This study looked at whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) in people who have had a kidney transplant and have chronic kidney disease. Researchers followed 55 patients for 6 months to see if the drug lowered protein levels and prote…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study looked at whether special programs can help people with chronic kidney disease get kidney transplants earlier and reduce racial differences in care. Over 1,100 adults with advanced kidney disease took part. The programs included a system to identify patients who might …

This study tested an experimental cell therapy called REACT (rilparencel) in 53 adults with type 1 or 2 diabetes and chronic kidney disease. The therapy involves injecting a person's own kidney cells into their kidneys to see if it can slow the loss of kidney function. The goal i…

This study tested a drug called Ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. The goal was to see if the drug could lower inflammation markers and find the best dose for a future heart study. Participants received monthly injections of eit…

This study tested a digital program called DDEP that helps people with chronic kidney disease and their care partners adopt healthier habits. Over 200 pairs participated, with one group receiving the digital program plus usual care and the other only usual care. The goal was to s…

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This study tested whether advanced ultrasound techniques can predict if a surgically created blood vessel connection (arteriovenous fistula or AVF) will work for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and function in 76 patients be…

This study tested whether adding empagliflozin (a diabetes drug) to standard diuretics helps hospitalized heart failure patients with moderate to advanced kidney disease urinate more fluid. 25 participants were given the combination, and researchers measured urine output. The goa…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This small pilot study tested a cognitive behavioral program to help reduce fatigue in people with chronic kidney disease. Five adults with moderate-to-severe kidney disease took part in remote sessions. The goal was to see if the program was acceptable and to gather data for a l…

This study tested whether a machine learning algorithm called BioVitals Index could predict patient deterioration better than traditional vital sign alarms. Researchers analyzed data from 526 patients receiving hospital-level care at home. The algorithm was trained to spot early …

This completed study from University Hospital Freiburg looked back at 490 patients with liver cirrhosis and signs of chronic kidney disease who were treated for hepatorenal syndrome. Researchers compared how well patients with and without pre-existing kidney disease responded to …

This study tested a program called DIAL-SDM that trains kidney doctors and coaches older patients (65+) with advanced kidney disease to have better conversations about dialysis. The goal was to see if the program was practical and acceptable. 102 patients, their caregivers, and 2…

This study looked at how sex hormones, especially estradiol, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of similar ages. The goal was to understand why women with CKD have …

This completed study looked at 50 non-diabetic people with chronic kidney disease to see if the drug dapagliflozin changes the types of bacteria in their gut. Researchers measured gut bacteria diversity and related waste products in the blood before and after 12 weeks of treatmen…

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and link them to patient outcomes. No new treatment was tested; instead, researchers aimed to …

This study tested whether a program of videos and text messages (called KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor. 422 adults who were already being evaluated for a kidney transplant took part. The study compared those who …

This completed study tested whether an on-screen electronic alert can prompt doctors to order a simple urine test for kidney disease in patients with type 2 diabetes. Many people with diabetes have early kidney damage but don't know it. The trial involved 400 adults who hadn't ha…

This study tested a personalized lifestyle counseling program for 120 adults with early-stage chronic kidney disease (CKD). Participants received tailored advice on diet, exercise, and healthy behaviors over 30 months. Researchers measured kidney function, waist and hip size, hea…

This study aimed to create a decision-making tool to help doctors identify which patients with severe acute kidney injury (treated with dialysis) are most likely to develop chronic kidney disease and would benefit from a nephrologist consultation. Researchers collected clinical i…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This completed study asked 140 people in the UK—including patients with chronic kidney disease, their families, healthcare professionals, and researchers—to identify the most important outcomes for self-managing the disease before dialysis is needed. Through multiple survey round…

This study tested two approaches to improve kidney disease care for Hispanic/Latinx and Black people with diabetes. First, community groups helped screen people for kidney disease and connect them to a primary care doctor. Second, clinics got support to help doctors screen and tr…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study tested an electronic alert system that reminds doctors to screen, monitor, and refer patients with chronic kidney disease (CKD). It involved 66 primary care centers in Stockholm, covering about 780,000 people. The goal was to see if the system improves detection and ma…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This study reviewed medical records of 345 adults to see if primary care doctors referred patients with chronic kidney disease to a kidney specialist at the right time and with the right treatment. The goal was to understand how well current referral practices work, not to test a…

This study tested whether sending digital letters to patients with chronic kidney disease and their family doctors could increase the use of recommended medications. Over 28,000 adults in Denmark took part. The goal was to see if simple reminders through the official government e…

This study looked at whether training community health workers to focus on kidney disease care, and teaching doctors about trauma-informed care, could improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. The study involved 153 patients fro…

This study looked at whether certain gene variants (APOL1) are linked to advanced chronic kidney disease (stage 4) in Afro-Caribbean adults living in Guadeloupe. Researchers analyzed blood samples from 88 participants to find how common these gene variants are. The goal was to be…