CHRONIC KIDNEY DISEASES

This study tested a drug called Ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. The goal was to find the best dose to lower inflammation and reduce heart risks. Participants received monthly injections of either 7.5 mg, 15 mg, or 30 mg of th…

This early-stage study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The main goal was to check the drug's safety and how the body processes it. Researchers measured side effects, vital signs, lab results, and …

This study tested whether giving hospital-level care at home is a good option for adults in rural areas who are acutely ill with conditions like infections, heart failure, or COPD. 160 participants received care at home instead of in a hospital. The study looked at costs, readmis…

This study tested whether a drug called Lokelma (SZC) can help people with both heart failure and chronic kidney disease safely take higher doses of standard heart medications (RAASi) without dangerous potassium spikes. 112 adults with moderate-to-severe kidney disease and heart …

This study looked at whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) of kidney transplant patients with chronic kidney disease. Researchers followed 55 patients for 6 months to see if the drug lowered protein levels and protected kidney funct…

This study tested an experimental drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose high blood pressure was not controlled by current treatments. The goal was to see if the drug could safely lower blood pressure and reduce kidney damage over …

This study looked at whether an educational worksheet plus health coaching can help people with chronic kidney disease (stages 3-5) and high blood pressure improve their blood pressure. 320 participants were split into two groups: one received the coaching and worksheet, the othe…

This study tested an experimental cell therapy called REACT (rilparencel) in 53 adults with type 1 or type 2 diabetes and chronic kidney disease. The goal was to see if injecting a person's own kidney cells back into their kidneys could slow the loss of kidney function. The treat…

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of inflammation (measured by hs-CRP). The goal was to see if monthly or quarterly injections could safely lower inflammation. The study compared the drug to a placebo and focused on …

This study looked at whether taking a prebiotic supplement and doing moderate aerobic exercise for 16 weeks could reduce inflammation and improve blood vessel health, thinking, and mood in people with stage 3-4 chronic kidney disease. About 68 adults aged 30-75 took part. The goa…

This study tested a new device that creates a connection between an artery and a vein in the arm for dialysis, without major surgery. It involved 24 adults with kidney failure who needed dialysis. The goal was to see if the procedure worked and to track any side effects over the …

This study looked at whether adding empagliflozin (a diabetes drug) to standard water pills helps people with acute heart failure and moderate-to-severe kidney disease urinate out more excess fluid. 25 adults participated, and researchers measured urine output over three hours. T…

This study tested whether using a more accurate blood pressure reading (central aortic pressure) instead of the usual arm cuff could help manage high blood pressure in people with advanced chronic kidney disease. 116 adults with kidney failure took part, and researchers checked i…

This study tested whether a computer alert in the medical record system could prompt doctors to order a urine test for kidney disease in patients with type 2 diabetes who hadn't had one in the past year. About 400 adults from primary care and specialty clinics took part. The goal…

This study tested whether community health workers and trauma-informed care training for doctors can improve quality of life for Black and Hispanic people with advanced chronic kidney disease. 153 patients from high-poverty areas in Philadelphia took part. The goal was to see if …

This study reviewed medical records of 345 adults with chronic kidney disease to see if they were referred to a kidney specialist at the right time and with the right treatment. Researchers wanted to find gaps in how primary care doctors manage early kidney problems. The goal is …

This study looked at whether a computer program could predict when patients being treated at home might get worse. Researchers used data from 526 patients in a home hospital program to train the machine learning model. The goal was to help doctors catch problems early and improve…

This study looked at data from 372 patients in a home hospital program to see if a computer algorithm could predict which patients would need to be readmitted within 30 days. Researchers used information like age, medical history, and lab results to train the algorithm. The goal …

This study tested whether 3D ultrasound can measure kidney and tumor volumes as accurately as CT or MRI scans. Researchers enrolled 53 adults with chronic kidney disease or kidney tumors. The goal is to see if a safer, radiation-free method can be used for monitoring.

This study looked at how sex hormones, like estrogen, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. The goal was to understand why women with CKD have higher …

This study tested whether sending digital reminder letters to patients with chronic kidney disease and their general practitioners could increase the use of recommended medications. Over 28,000 adults in Denmark took part. The letters highlighted updated treatment guidelines and …