CHRONIC KIDNEY DISEASES

This study tests whether mindfulness meditation and a mild nerve stimulation device can improve nerve function and blood pressure in people with chronic kidney disease. About 150 participants with moderate kidney disease will take part. The goal is to see if these approaches can …

This study tests whether a potassium-lowering drug called sodium zirconium cyclosilicate (Lokelma) can help elderly patients with heart failure and chronic kidney disease safely take higher doses of RAASi medications, which are often limited by high potassium levels. The trial wi…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study tests a device that uses radiofrequency energy to calm overactive nerves in the kidney and liver, which may help lower blood pressure. Researchers will enroll 175 adults with uncontrolled hypertension, with or without high cardiovascular risk. The goal is to see if the…

This study compares taking two blood thinners (aspirin plus clopidogrel or prasugrel) for less than 3 months versus at least 6 months after a heart stent procedure in people with advanced chronic kidney disease. Researchers want to see if a shorter course reduces bleeding without…

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure changes in heart structure and pumping ability using ultrasound. The trial enrolls 20 adults with moderate to severe kidney d…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works…

This study is testing whether a combination of green propolis extract and royal jelly can reduce inflammation and oxidative stress in people with chronic kidney disease or high blood pressure. Over two months, 153 participants will take either the supplement or a placebo. Researc…

This phase 3 study tests a treatment called REACT (rilparencel) for people with type 2 diabetes and chronic kidney disease. The treatment involves injecting the patient's own kidney cells to help slow down kidney function loss. About 685 adults aged 30-80 will be randomly assigne…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This study is for adults with chronic kidney disease (CKD) who are already receiving standard care. It tests different treatments, alone or in combination, to see which best slows kidney decline and prevents kidney failure. About 1,000 participants will be followed for over two y…

This study tests a program called Med AAAction for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. The program provides free medications, delivers them to the bedside and then home, and assigns a health coach to help with follow-…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests whether using a home blood pressure monitor paired with a smartphone, plus support from a case manager, can better control blood pressure in people with chronic kidney disease who live in remote areas. About 146 participants in northern Alberta will either use th…

This early-stage study tests whether stem cells from human amniotic fluid can help heal painful skin wounds (calciphylaxis) in people with chronic kidney disease. Nine participants will receive the stem cell treatment, and researchers will measure wound healing and pain levels. T…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive a conditioning treatm…

This early-phase study at Mayo Clinic tests whether it is possible to transplant a kidney and a bladder together in people who have both kidney failure and a damaged or missing bladder. Up to 30 participants aged 1 to 60 will receive the combined transplant and be followed for up…

This study tests a program called NAVIGATE-Kidney for 448 adults with advanced chronic kidney disease. The program provides extra support and education to help patients start kidney replacement therapy (dialysis or transplant) in a planned way, rather than needing an emergency st…

This study tests a special wrap called SelfWrap that is placed around blood vessels during surgery to create a connection for dialysis. The wrap helps the vessels grow strong and work well without extra procedures. About 600 adults with advanced kidney disease who need a new dial…

This study tests whether a drug called ferric citrate can lower a harmful protein (FGF23) in children aged 6–18 with moderate chronic kidney disease. About 160 kids will take either the drug or a placebo for 12 months. The goal is to see if the drug is safe and helps control kidn…

This study tests whether a specially designed health behavior program can help people with metabolic syndrome and chronic kidney disease reduce their waist size and improve kidney function. Researchers will compare the program to usual care in 160 adults, measuring changes in wai…

This study tests the safety of using donor bone marrow stem cells in 75 adults with chronic kidney disease, including kidney transplant recipients. The stem cells are given through a vein or directly into the kidney arteries. The goal is to see if this approach is safe and tolera…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study tests whether patiromer, a drug that lowers potassium, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and lower …

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests a new treatment for high blood pressure in people with moderate to severe chronic kidney disease. It uses low-intensity shockwaves applied to the kidneys over three weeks. The goal is to see if this treatment can safely lower blood pressure and improve kidney fun…

This study tests whether a 12-week physical activity program helps teens with chronic kidney disease (CKD) become more active. About 100 teens aged 13-18 with CKD (stages II-V, not on dialysis or with a transplant) will wear a Fitbit to track their activity. The goal is to see if…

This study tests whether a single dose of equol, a compound made from soy, can improve blood vessel function in postmenopausal women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taking equol. The goal is t…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This study tests a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsies. The goal is to see if this method can identify signs of acute kidney injury or chronic kidney disease as well as or better than standard microscope an…

This study tests whether a special ultrasound technique called shear wave elastography can quickly and safely tell the difference between acute and chronic kidney disease in the emergency room. Researchers will measure kidney stiffness in 800 adults and compare it to standard tes…

This study tests whether a team of doctors and pharmacists can safely reduce unnecessary medications in 424 adults with chronic kidney disease in Qatar. Participants will either receive the deprescribing intervention or usual care. The goal is to lower the number of risky or unne…

This pilot study tests whether a device that gently stimulates a nerve in the ear (taVNS) is safe and tolerable for people with chronic kidney disease stages 3-5 who have autonomic nervous system dysfunction. Thirty participants will use the device daily for two weeks. The main g…

This study tests whether a smartphone app can help people with kidney problems control body swelling by guiding daily adjustments to their water pill (diuretic) dose. Thirty adults with advanced kidney disease or nephrotic syndrome who have swelling will use the app for 90 days, …

This pilot study tests whether a 12-week high-velocity resistance training program is safe and doable for older adults with advanced chronic kidney disease. Thirty participants will either do the exercise program or join weekly healthy lifestyle sessions. The goal is to see if th…

This study looks at whether taking beetroot extract along with a supervised exercise program can reduce inflammation and oxidative stress, and improve physical function and quality of life in people with chronic kidney disease (stages 3a-4). Researchers will enroll 25 adults aged…

This study looks at whether a simple home-based walking program can boost memory, thinking skills, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, participants will either walk regularly or receive h…

This study tests a medicine called difelikefalin in teenagers aged 12 to 17 who are on hemodialysis and have moderate to severe itching. The goal is to see if the drug is safe and how much gets into the blood. About 18 teens will receive the medicine up to 4 times a week for 12 w…

This study is testing whether a blood test that looks at tiny genetic molecules called microRNAs can accurately detect bone problems in people with chronic kidney disease. Currently, doctors rely on a bone biopsy, which is invasive and not practical for most patients. The researc…

This study tests two programs to help people aged 75 and older with advanced kidney disease decide on their treatment. One program provides standard information and support, while the other adds a video decision aid and coaching from a specialist. Researchers will compare which a…

This study looks at why people with chronic kidney disease (CKD) often lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1,000 adults with CKD to find risk factors and see how muscle loss affects their health over time. The goal is to better un…

This study follows 300 preterm and full-term infants from birth to age 10 to understand how early birth affects kidney and heart health. Researchers use ultrasound and blood tests to detect early signs of kidney damage or high blood pressure. The goal is to identify at-risk child…

This study looks at how the eyes, brain, and kidneys affect each other in people with chronic kidney disease (CKD). Researchers will use MRI scans and eye imaging to see if changes in the brain and retina are linked to thinking problems and kidney function. About 1,500 adults wit…

This study examines how chronic kidney disease weakens the immune system, specifically T-cells, in 100 patients. Researchers will also test a method in the lab to engineer T-cells to work better. The goal is to understand the immune problem and see if a cell-based fix is possible…

This study looks at how blood pressure and artery stiffness change between day and night in 120 people at increased risk for heart disease, including those with kidney problems. Participants wear a device that measures these values over 24 hours and provide blood and urine sample…

This study observes 1000 people with severe aortic stenosis and kidney disease who are getting a TAVI procedure. Researchers want to see how removing the blocked valve affects the kidneys' response to contrast dye used during the procedure. The goal is to understand if TAVI lower…

This study will check 3,000 adults at a large hospital in Prague to see how many have chronic kidney disease and how many of those cases were previously unknown. Participants must be over 50 or over 18 with conditions like diabetes, high blood pressure, or heart disease. No treat…

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals in 60 adults. The goal is to understand how the drug works b…

This study looks at a rare but serious condition called calciphylaxis, where small blood vessels in the skin harden, often leading to death. Researchers will compare 860 adults with chronic kidney disease—some who have calciphylaxis and some who don't—to find clues about what cau…

This study follows 200 adults with advanced chronic kidney disease as they start dialysis, comparing those who choose home dialysis with those who go to a center. Researchers will track quality of life, frailty, fatigue, mood, and thinking skills every 3 to 6 months for a year. T…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and looking at conditions like diabetes, high blood pressure, a…

This study is for people who received a kidney transplant and have reduced kidney function. It aims to understand how the drug dapagliflozin affects the structure and blood flow of the transplanted kidney. About 48 participants will be randomly assigned to take dapagliflozin or n…

This study is looking at 300 people with type 2 diabetes who have high levels of protein in their urine, a sign of kidney trouble. Researchers will take small samples of kidney tissue (biopsies) and analyze blood, urine, and stool to find patterns that could improve diagnosis and…

This study looks at how social needs—like food, housing, or safety—affect the health and self-care of African American adults with both type 2 diabetes and chronic kidney disease. Researchers will talk with 330 participants to understand what helps or hinders their care. The goal…

This study tests easier methods to measure how well the kidneys can handle extra work (kidney reserve). It involves 44 adults with sickle cell kidney disease or who have donated a kidney. Participants take a protein drink, and researchers check changes in a blood test called eGFR…

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study aims to learn why American Indians are at high risk for chronic kidney disease and heart disease. Researchers will follow 500 participants over time, measuring kidney function and tracking heart problems. The goal is to identify key risk factors to improve prevention a…

This early-stage study looks at whether it's possible to run a larger trial of empagliflozin, a diabetes drug, in 40 children with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. Researchers will check if the drug i…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years, tracking their health and sleep patterns. The goal is to fi…

This study looks at how the sedative remimazolam behaves in the body of 30 adults receiving a kidney transplant. Researchers will measure drug levels in the blood and monitor sedation depth to ensure safe and predictable anesthesia. The goal is to gather information for better se…