CHRONIC KIDNEY DISEASES

This large international study is testing different treatments, alone or in combination, to slow the worsening of chronic kidney disease (CKD). The goal is to prevent or delay kidney failure so fewer people need dialysis or a transplant. About 1,000 adults with CKD who are alread…

This study tests if a device called the Gemini System can safely lower blood pressure by targeting nerves in the kidney and liver. It includes 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The main goal is to se…

This study looks at whether using a home blood pressure monitor plus a dedicated case manager can better control blood pressure in people with chronic kidney disease who live far from clinics. About 146 participants in northern Alberta will either get usual care or extra help fro…

This study looks at how long people with advanced chronic kidney disease should take two blood thinners (aspirin plus clopidogrel or prasugrel) after getting a heart stent. About 900 adults with severe kidney disease will be randomly assigned to either 3 months or 12 months of du…

This study tests the safety of giving bone marrow stem cells to 75 people with chronic kidney disease, including some who have had a kidney transplant. The stem cells are given through a vein or directly to the kidneys. The goal is to see if this approach is safe and tolerable, n…

This study tests if giving two medicines, tranexamic acid and desmopressin, before surgery can help reduce bleeding in people with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who are having non-cardiac surgery will take part. The goal is t…

This study tests a special wrap called SelfWrap placed around blood vessels during fistula creation for dialysis. It aims to help the fistula mature faster and work without extra procedures. About 600 adults with chronic kidney disease needing a new fistula will take part and be …

This study tests a team-based program to help chronic kidney disease patients in Qatar safely reduce unnecessary or harmful medications. About 424 adults on dialysis or pre-dialysis will be randomly assigned to the program or usual care. The goal is to lower medication burden, im…

This study tests whether a drug called ferric citrate can lower a key protein linked to kidney disease progression in children aged 6-18 with moderate chronic kidney disease. About 160 participants will receive either the drug or a placebo for 12 months. The goal is to see if the…

This study looks at whether mindfulness meditation can improve nerve function in people with chronic kidney disease (CKD). Researchers will also test if a mild nerve stimulation device can boost the effects of meditation. The goal is to see if these approaches can lower blood pre…

This study is testing a new way to look at kidney tissue samples using a special light-based imaging method called dynamic full-field optical coherence tomography. The goal is to see if this method can diagnose acute kidney injury or chronic kidney disease faster and more accurat…

This study tests a special ultrasound technique called shear wave elastography to help doctors quickly tell if kidney disease is acute (new) or chronic (long-standing). The goal is to make diagnosis faster and safer for patients in the emergency room, avoiding the need for contra…

This study tests whether a 12-week high-velocity resistance training program is safe and doable for older adults with advanced chronic kidney disease. Researchers will compare the exercise group to a group that attends weekly healthy lifestyle sessions. The goal is to see if this…

This study tests if a simple home-based walking program can improve memory, thinking speed, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, 144 participants will either walk regularly or receive heal…

This study tests a medicine called difelikefalin to see if it safely reduces severe itching in teenagers (ages 12-17) who are on hemodialysis for chronic kidney disease. About 18 teens will receive the drug three times a week for up to 12 weeks during their regular dialysis visit…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive one of two treatment strategies: behavioral activation teletherapy plus a non-SSRI antidepressant if needed, o…

This study tests whether a 12-week physical activity program helps teens with chronic kidney disease (CKD) become more active. About 100 teens aged 13-18 with CKD (not yet on dialysis or with a transplant) will wear a Fitbit to track their daily moderate-to-vigorous exercise. The…

This study tests whether a mobile phone app can help people with kidney problems control body swelling by guiding daily adjustments to their water pill (diuretic) dose. Thirty participants will use the app for 90 days, entering daily weight and blood pressure readings. The app th…

This study aims to understand why some people with chronic kidney disease (CKD) develop muscle loss (sarcopenia) and how this affects their health. Researchers will follow 1000 adults with CKD to identify risk factors and see if muscle loss leads to worse outcomes like disease pr…

This study aims to collect and analyze kidney tissue from 1,000 people with acute or chronic kidney disease, including those with diabetes. By studying the tissue in detail, researchers hope to identify different types of kidney disease and find new targets for treatments. Partic…

This study tests new, simpler methods to measure how well the kidneys can handle extra work (kidney reserve). It includes people with sickle cell kidney disease and those who have donated a kidney. The main goal is to see if a protein drink can safely and effectively measure kidn…

This early-stage study looks at whether it's possible to run a larger trial of a drug called empagliflozin (a diabetes medicine) in 40 children with chronic kidney disease. The drug is given daily for 3 months to see if it improves blood pressure, urine markers, and heart functio…

This study follows 200 adults with advanced chronic kidney disease as they start dialysis at home or in a center. Researchers will track quality of life, frailty, fatigue, and mood every 3 months for a year. The goal is to see if home dialysis helps people stay healthier and feel…

This study looks at whether a single dose of equol, a substance made from soy, can improve blood vessel function in postmenopausal women. It includes women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taki…

This study looks at how dapagliflozin, a drug used for diabetes, affects the heart and metabolism in people with chronic kidney disease. Researchers will measure heart function and blood markers in 60 adults. The goal is to understand how the drug works, not to test a cure.

This study aims to uncover the molecular mechanisms behind kidney disease, immune disorders, and complications in organ transplant patients. Researchers will analyze blood and urine samples from 5,000 adults to find genetic and protein markers that predict disease progression or …

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes their kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years. The goal is to find risk factors and help doctors det…

This study looks at how social needs (like food, housing, or safety) affect self-care and health in African American adults with diabetic kidney disease and type 2 diabetes. Researchers will talk with 330 participants to understand barriers and then create a culturally tailored p…

This study follows 300 preterm and full-term infants from birth to age 10 to understand how early birth affects kidney and heart health. Researchers use ultrasound and blood/urine tests to find early warning signs of kidney injury or high blood pressure. The goal is to identify a…