CHRONIC KIDNEY DISEASES

This study tests a new drug called QRX3 in 3,000 people with chronic kidney disease. The goal is to see if it can improve kidney function and slow the disease's progression. Participants will take QRX3 capsules, and researchers will measure changes in kidney function over time.

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This study tests whether a supplement made from jaboticaba peel can help people with chronic kidney disease by reducing inflammation, oxidative stress, and gut bacteria imbalances. Thirty adults with kidney disease will take either the jaboticaba extract or a placebo for one mont…

This study looks at whether doing handgrip exercises at home for 8 weeks can help lower blood pressure in people with chronic kidney disease (CKD). Researchers will also study why blood pressure rises, such as from stress hormones or stiff blood vessels. The study involves 50 adu…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either the drug or standard care for 2 years. Researchers will track kidney funct…

This study checks if a new handheld device can accurately measure creatinine levels from a fingerstick at home, compared to standard lab tests. About 200 adults with kidney disease will use the device themselves and answer a questionnaire about how easy it is to use. The goal is …

This study tests an 8-week health literacy program designed to help people aged 55-74 who take five or more daily medications prevent chronic kidney disease. The program teaches skills like medication management, healthy eating, and physical activity. Researchers will compare hea…

This study tests whether doing virtual reality exercise during dialysis can help patients with end-stage kidney disease keep their electrolytes (sodium, potassium, calcium, phosphorus) in a healthier range. Forty adults on regular dialysis will either do 30 minutes of VR cycling …

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This study tests whether a computer alert that pops up when doctors open a patient's chart can increase prescriptions of recommended medications for chronic kidney disease. About 1000 patients will take part. The alert shows the patient's lab results and suggests medications they…

This observational study will enroll 80 adults aged 18 to 75 to explore whether gum disease (periodontitis) and chronic kidney disease are linked. Researchers will collect mouth and fecal samples to analyze bacteria, and measure kidney function and gum health. The goal is to unde…

This study tests whether a digital program (videos, texts, and optional phone support) can help people with kidney failure get more inquiries from potential living donors. About 430 adults referred for a kidney transplant will be randomly assigned to get the program with or witho…

This very early study (Phase 1) will give a single dose of a radioactive-labelled drug called HRS-1780 to 6 healthy men. The goal is not to treat disease but to track exactly how the drug is absorbed, broken down, and eliminated from the body. Results will help design future stud…

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…