Bone fracture

This phase 3 trial tests whether adding a local injection of the antibiotic tobramycin to standard IV antibiotics can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because the wound may not get enough blood flow for IV antibiotics…

This trial tests whether custom-made, 3D-printed titanium plates can improve surgery for cheekbone fractures. The plates are designed from CT scans of the patient's healthy side to guide precise reconstruction. Researchers will compare the surgical result to the virtual plan, and…

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This trial tests whether a comprehensive hand and arm strength training program, which includes using an upper-limb treadmill, can improve range of motion and function in children aged 6 to 16 who have elbow stiffness after a fracture. The study measures elbow movement with a gon…

This study tested whether ketotifen, an allergy medicine, can prevent elbow stiffness after a fracture or dislocation. 395 adults took either a low or high dose of ketotifen or a placebo pill twice daily for 6 weeks. The main goal was to see if the drug improved elbow range of mo…

Osteoporosis weakens bones and raises fracture risk, but the best exercise for building bone is unclear. This trial tests two supervised strength-training programs in adults aged 50 and older with low bone density. One group lifts at a moderate intensity (70% of their max), the o…

This study tested whether a two-year course of teriparatide (a bone-building drug) followed by a single infusion of zoledronic acid (a bone-strengthening drug) could reduce fractures in adults with osteogenesis imperfecta, also known as brittle bone disease. 350 participants were…

This study looked at whether giving tranexamic acid before surgery can reduce blood loss in people with broken thigh or shin bones. Fifty-four patients received either the drug or a placebo before their operation. Researchers measured blood loss during and after surgery, as well …

This study looked at two osteoporosis medications—romosozumab and denosumab—in 54 people who take long-term steroids and have weak bones. Participants first received either romosozumab for 12 months followed by denosumab, or denosumab alone for 24 months. Then everyone stayed on …

This study looked at whether a one-day course of antibiotics is as good as a three-day course at preventing infections after femur or tibia fracture surgery with a metal rod (intramedullary nailing). Fifty-six adults were randomly assigned to receive either three or nine doses of…

This study looked at how well the Gamma4 nail system works for fixing thigh bone fractures. 100 adults who needed this surgery were followed for a year to see if their bones healed and to check for any problems. The goal was to see if the nail helps bones heal properly without ca…

This study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured us…

This study followed 148 people who had a procedure called Subchondroplasty® for stress fractures or bone defects in the foot or ankle. Researchers tracked pain, function, and satisfaction for up to 24 months after surgery. The goal was to see how well the procedure helps patients…

This study tested whether a daily supplement made from kefir peptides could help heal broken bones faster in postmenopausal women with osteoporosis. Thirty women with upper arm or wrist fractures were randomly assigned to receive either the kefir supplement or standard care alone…

This study tested whether putting antibiotic powder (vancomycin or tobramycin) directly into open fracture wounds right after injury can prevent infections. Twenty adults with severe open fractures of the arm or leg took part. The goal was to see if this simple step reduces surgi…

This study looked at how safe and effective the JuniOrtho plating system is for treating congenital deformities and fractures in the lower limbs of 30 children and adults. The device is a metal plate and screws used during surgery to hold bones in place while they heal. Researche…

This study looked at two ways to treat a rare break in the jaw joint (condylar head fracture): surgery to fix the bone, or non-surgical care with advice and exercises. 14 adults with this injury took part. The goal was to see which approach leads to better chewing and jaw functio…

This study tested two methods of making custom metal plates to fix broken jawbones. Sixteen patients with fractures between the chin and lower teeth received plates made either by 3D printing (additive) or by computer-controlled machining (subtractive). Researchers measured the p…

This study tested a robotic system called EPIONE that helps doctors guide needles into bones during CT scans. The robot is used for procedures like biopsies, tumor treatments, and bone repairs. Researchers wanted to see if the robot could make these procedures safer and more accu…

This study tested a special silver-coated metal plate (LOQTEQ) used to fix broken ankle bones. The goal was to see if it is safe and reduces infections compared to standard uncoated plates. 203 adults with distal fibula fractures took part. Researchers tracked side effects and in…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

This pilot study tests whether a high-resolution CT scan (HRpQCT) can improve the diagnosis of scaphoid fractures, a common wrist injury in young adults. Participants with a suspected scaphoid fracture will receive both a standard CT and an HRpQCT scan to compare accuracy. The go…

This study tests whether artificial intelligence (AI) can help emergency room doctors find broken bones, dislocations, and other bone problems more quickly and accurately. About 4,800 patients with arm or leg injuries will have their X-rays reviewed either with or without AI assi…

This trial tests whether a portable ultrasound device, used at the patient's bedside, can accurately detect hip fractures after a fall or injury. Researchers will compare ultrasound findings with standard X-rays in 146 adults with suspected hip fractures. If proven reliable, ultr…

This study looks at whether a new DNA sequencing technology (Nanopore) can better identify infections in broken bones compared to standard lab cultures. Researchers will collect bone samples from 100 adults with fracture-related infections and compare the results from both method…

This study tested a new imaging method called 3D-DXA to measure bone density in the spine, comparing it to standard CT scans. Researchers enrolled 120 adults who already needed a CT scan. The goal was to see if the 3D-DXA technique, which uses less radiation, could give equally a…

This study tested an artificial intelligence (AI) program called Carebot AI Bones to see how well it finds fractures on X-rays. Researchers compared the AI's performance to that of experienced radiologists using 600 X-rays from both children and adults. The goal was to see if the…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This study tested whether a new ultra low-dose CT scanner can find bone fractures as well as standard X-rays, but with less radiation. Over 500 emergency patients with suspected breaks in the spine, pelvis, or limbs were scanned using both methods. The goal was to see if the low-…

This study tested whether an AI tool called Boneview helps clinicians spot fractures on X-rays more accurately. 18 doctors and other health professionals reviewed 500 X-ray images, half with fractures and half without, first without AI and then with AI assistance. The goal was to…

This study tested whether a cone-beam CT scanner (Newtom 5G) can detect and classify fractures of the arms and legs as accurately as a standard CT scan. 43 adults with suspected fractures received both scans. Researchers compared how well each scan identified the type of fracture…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested two approaches to prevent serious fall injuries in older adults (65+) who had a prior bone fracture. One group received enhanced usual care, while the other received exercise coaching. Researchers tracked serious fall injuries, falls, and overall health over 36 …

This study looked at whether taking daily vitamin D or fish oil supplements can help prevent bone fractures in healthy adults. Over 25,000 men and women without prior cancer or heart disease took part. Researchers tracked fractures over time and also checked if genetics or starti…

This study looked at over half a million older adults in Taiwan who were hospitalized for a bone fracture. Researchers compared those who had received a flu vaccine in the past year to those who had not. They found that vaccinated patients had fewer infections and a lower chance …

This trial tests whether giving a steroid injection just before surgery for a broken leg can reduce swelling and pain compared to a placebo. Adults with certain leg fractures who need surgery within 72 hours are randomly assigned to receive either the steroid or a saline injectio…

This trial tests whether adding a topical gel containing naproxen and lidocaine to standard intravenous pain medication improves pain relief for adults with isolated rib fractures from blunt chest trauma. Participants receive either the standard IV painkiller alone or the IV pain…

This study tested whether adding photobiomodulation (light therapy) to standard physical therapy helps military trainees with leg stress fractures heal faster. 105 participants received either real or sham light therapy for up to 6 weeks, and researchers tracked how quickly they …

This trial tests whether a very low dose of two drugs—dexmedetomidine and esketamine—given at night can improve sleep quality in older adults (65-89 years) undergoing knee or hip replacement. Poor sleep after surgery is common and linked to worse recovery. The study compares the …

This study compared two pain-blocking injections for people with multiple broken ribs. One method (paravertebral block) is effective but risky; the newer retrolaminar block may be safer and easier. Sixty adults with rib fractures received one of the two blocks, and researchers me…

This study tested whether briefly restricting blood flow to the leg during physical therapy could help people regain strength and muscle after a broken femur (thigh bone). 219 adults aged 18-55 with a closed femur fracture took part. The approach uses a special tourniquet system …

This study tested a digitally enhanced nursing discharge program for older adults recovering from limb fractures. The program uses interactive digital content and phone follow-ups to teach pain management, coping, and recovery strategies. Researchers compared it to standard care …

This study tested whether giving fluoxetine (Prozac) to people with serious bone fractures could prevent or reduce depression, anxiety, and other mental health issues that often follow such injuries. 55 adults with broken bones requiring surgery were randomly assigned to take eit…

This study tested a procedure called cryoneurolysis, which uses a device to freeze nerves near broken ribs to block pain. It involved 43 adults aged 18-64 with rib fractures who were not candidates for surgery. The goal was to see if this approach could lower pain scores and redu…

This study compared two types of nerve blocks—rhomboid intercostal and sub-serratus block versus thoracic paravertebral block—for pain relief and lung function in 50 adults with multiple rib fractures. The goal was to see which block better improves breathing and reduces pain. Re…

This study tested a new hollow cusp fracture reducer for fixing broken thigh and kneecap bones. 142 patients were split into two groups: one got the new device, the other had standard manual reduction. The new tool shortened surgery time, reduced X-ray use, and improved accuracy …

This study tested whether combining ketamine with propofol reduces agitation during recovery from sedation, compared to ketamine alone. 150 adults needing sedation for a broken bone or dislocation were randomly assigned to one of the two drug combinations. The main goal was to se…

This study tested a procedure called cryoneurolysis, which uses a cold probe to freeze nerves around broken ribs, in 127 elderly patients. The goal was to reduce pain and the need for strong narcotics, helping patients recover faster. Researchers measured pain scores at discharge…

This study tested whether a nerve block called an erector spinae plane (ESP) block is practical to use in trauma patients with broken ribs. It included 27 adults with rib fractures and moderate to severe pain. The goal was to see if a larger trial is possible, not to prove the bl…

This study tested whether a drug called dexmedetomidine can help control pain and reduce the need for strong painkillers (opioids) in people with three or more broken ribs from blunt chest injuries. 41 adults in the ICU took part. The goal was to see if the drug could lower pain …

This study tested a computer-controlled method of giving propofol sedation to 45 adults in the emergency department. The goal was to find the right brain concentration needed for deep sedation during painful procedures like fixing a broken bone or putting a dislocated joint back …

This study tested a procedure called cryoanalgesia, which uses cold to numb nerves, for treating pain from broken ribs. Five adults with rib fractures received the treatment to see if it could improve pain control and reduce the need for strong painkillers. The goal was to find a…

This study tested whether an ultrasound-guided nerve block (Serratus Anterior Plane Block) can improve pain, breathing, and coughing in emergency room patients with rib fractures. Forty adults with confirmed rib fractures received either the nerve block or usual care. Researchers…

This study looked at whether adding relaxation exercises and classical foot massage to standard physical therapy helps people recover after hip fracture surgery. Forty patients aged 50 and older took part. Researchers measured pain, mobility, quality of life, anxiety, depression,…

This study looked at 304 children aged 2 to 17 with broken arm or leg bones who came to the emergency room in severe pain. Researchers wanted to see if giving paracetamol (Tylenol) or ibuprofen (Advil) along with morphine worked better than morphine alone. They measured pain leve…

This study tested whether adding a sedative (midazolam) to standard morphine painkiller helps children with arm fractures feel less pain. Sixty children aged 5 to 16 were split into two groups: one got morphine plus midazolam, the other got morphine plus a placebo. Researchers me…

This study compared two types of nerve blocks—Quadroiliac Plane Block and PENG Block—for pain relief after femur fracture surgery. 52 adults were randomly assigned to receive one of the blocks. Researchers measured pain scores and how much opioid painkiller patients needed in the…

This study tested whether cognitive behavioral therapy (CBT) can reduce persistent pain after fracture surgery. Over 1,000 adults with broken arm or leg bones received either CBT or usual care. The goal was to see if CBT lowers the number of people who still have moderate to seve…

This study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…

This study investigates how often adults remember events during procedural sedation with propofol in the emergency department, specifically for fracture or joint dislocation reduction. About 250 participants will be asked a questionnaire the day after sedation to check for any re…

This study looked at whether vitamin D levels affect how well broken bones heal in young adults aged 18 to 25. Researchers measured vitamin D at the time of injury and tracked healing for up to a year. The goal was to understand if low vitamin D is linked to slower healing or com…

This study examined bacteria in severe leg wounds of 646 adults (ages 18-64) with open tibia fractures or traumatic amputations. Researchers took samples at the time of wound closure to see if certain bacteria led to deep infections within 30 days to one year. The goal was to bet…

This study looked at 100 patients who had a new, less invasive surgery to fix an unstable chest wall after a serious injury. The surgery uses smaller cuts and spares the muscles. The goal was to see how well their lungs worked and how they recovered, compared to patients who had …

This study looked at over 1,000 patients with multiple rib fractures to see how age and injury severity affect hospital outcomes after surgical repair. Researchers compared those who had surgery with those who did not, tracking deaths, time on a ventilator, and length of hospital…

This completed study looked at 86 patients who had a fracture possibly due to weak bones (osteoporosis). Researchers wanted to see if the calcium supplements patients were prescribed matched what they actually got from food. Many patients get calcium pills even if their diet alre…

This study looked at 40 adults who had to wear a splint or cast on their dominant hand for 6 weeks after an injury. The goal was to see if being forced to use the non-dominant hand actually improves its function. Researchers measured hand skills and disability levels to understan…

This early-stage study tested several new oral tablet versions of a bone-building hormone (hPTH 1-34) in 45 healthy men aged 18-35. The goal was to see how well the body absorbs these new tablets compared to an existing oral tablet and a standard daily injection. Researchers meas…

This study tested a new way to measure blood flow in broken bones using a safe dye and a special camera. Researchers followed 104 fracture patients to see if poor blood flow leads to infections or other complications. The goal was to learn how to better predict and treat bone inf…

This study followed 912 men and women over 60 in France who were hospitalized for severe osteoporotic fractures. Researchers tracked how many had another severe fracture within 2 and 5 years, and how many died during that time. The goal was to better understand the long-term risk…

This study looked at how well the Chimaera intramedullary nail works in elderly patients with hip fractures. Researchers tracked 206 people aged 65 and older who had surgery with this device. The main goal was to see how many needed a second surgery due to problems, and they also…

This study translated the New Mobility Score into Turkish and tested how well it works for elderly people who had hip fracture surgery. 120 participants answered questions about their walking ability and also took other tests. The goal was to see if the Turkish version is a relia…

This study tested whether sending three text message reminders to adults over 50 who had a low-trauma fracture would encourage them to get a bone density test. The goal was to improve screening for osteoporosis, a condition that weakens bones. Researchers enrolled 97 patients fro…

This study looked at nearly 20,000 adults with asthma to see if long-term use of inhaled or oral steroids increases the risk of osteoporosis (weak bones) and other metabolic diseases like diabetes and high blood pressure. Researchers compared people who took higher total doses of…

This completed study looked at 40 adults with certain types of spine fractures in the chest or lower back that did not cause nerve problems. Researchers compared outcomes between patients who had surgery (spinal fusion) and those who received conservative care like bracing and ex…

This study looked at how well the CHIMAERA nail, a metal rod placed inside the thigh bone, helps heal certain types of hip and upper thigh fractures. Researchers reviewed medical records of 44 adults who had the surgery to see if the bone healed within a year and if any additiona…