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Bone filler injection in hip shows promise for pain relief

NCT ID NCT03494660

Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured using standard hip scores and pain scales.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
calcium phosphate bone filler (AccuFill)
What this could lead to
If successful, this procedure could offer a minimally invasive option to reduce hip pain and improve function for people with certain bone defects.
What could go wrong
This is a small, completed study without a comparison group, so results may not apply to everyone. The procedure may not work for all types of hip problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

77 people

The number who actually took part.

Started

Mar 2018

Finished

Jan 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Approximately 50 subjects, each with at least one subchondral bone defect in the form of a cyst and/or bone marrow lesion (BML), insufficiency fracture or bone defect associated with early stage avascular osteonecrosis (AVN) in the femoral head, femoral neck and/or acetabulum who are suitable candidates for use of AccuFill during the Subchondroplasty Procedure are eligible for enrollment in this study.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Candidates must meet ALL of the following: 1. Surgeon considers the patient appropriate for the SCP Procedure of the hip. 2. Subchondral bone defect(s) in the femoral head, femoral neck and/or acetabulum has been confirmed via radiographic finding on MRI or x-ray. 3. Subject provides voluntary signature on the IRB approved Informed Consent Form. 4. Subject is at least 18 years of age. 5. Subject must be physically and mentally willing and able, in the Investigator's opinion at the time of enrollment, to be compliant with the protocol and complete outcome forms via email, telephone, in-person or by regular mail. Exclusion Criteria: * Candidates will be excluded if they meet ANY of the following: 1. Subject has collapse of subchondral bone. 2. Subject is pregnant at the time of surgery. 3. Subject is incarcerated. 4. Subject is involved in active litigation related to the condition being treated. 5. Subject is not comfortable with speaking, reading, and understanding questions and providing responses in an available language for the PROs in the protocol.

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Conditions

The condition(s) this trial relates to.

avascular necrosis avascular necrosis of femoral head, primary, 1 bone fracture developmental dysplasia of the hip Femoracetabular Impingement Fractures, Stress Hip Dislocation solitary bone cyst

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Avascular necrosis of hip Bone marrow edema Dysplasia; hip Femoroacetabular impingement Insufficiency fractures Subchondral bone edema Subchondral cysts

Contacts and locations

Locations

  • Andrews Research & Education Foundation

    Gulf Breeze, Florida, 32561, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Eisenhower Desert Orthopedic Center

    Rancho Mirage, California, 92270, United States

  • OrthoIllinois

    Rockford, Illinois, 61114, United States

  • The Ohio State University

    Columbus, Ohio, 43202, United States

  • University of Kentucky Research Foundation

    Lexington, Kentucky, 40506, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.