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Antidepressant may ease mental toll of broken bones

NCT ID NCT04850222

First seen Apr 24, 2026 · Last updated May 23, 2026 · Updated 5 times

Summary

This study tested whether the antidepressant fluoxetine can reduce depression, anxiety, and other mental health issues in adults recovering from serious bone injuries requiring surgery. Over half of such patients develop lasting mental health problems. The trial enrolled 55 adults and measured mood, sleep, and PTSD symptoms. The goal was to see if a simple, short-term medication could help when talk therapy alone is not enough.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • University of Florida

    Gainesville, Florida, 32608, United States

Conditions

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