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New pain relief approach for broken ribs shows promise in cutting opioid use

NCT ID NCT05321121

Symptom relief Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a drug called dexmedetomidine can help control pain and reduce the need for strong painkillers (opioids) in people with three or more broken ribs from blunt chest injuries. 41 adults in the ICU took part. The goal was to see if the drug could lower pain scores and morphine use over 48 hours.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

41 people

The number who actually took part.

Started

Nov 2021

Finished

Oct 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Blunt trauma patients * \> 3 rib fractures * Admission to the ICU Exclusion Criteria: Exclusion criteria: * Younger than 18 * Pregnant * Prisoners * History of adverse reaction to dexmedetomidine * GCS \< 14 * Acute CHF exacerbation * Bradycardia or heart block (HR \<55) * Hypotension (SBP \< 90mmHg or MAP \< 65mmHg) * Current opioid use (\>30mg OME/day) * Inability to communicate with staff (dementia) * Cirrhosis or chronic liver dysfunction (Child Pugh class C)

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Conditions

The condition(s) this trial relates to.

Acute Pain bone fracture Pain Rib Fractures

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain, acute Rib fractures

Contacts and locations

Locations

  • University of California, Irvine

    Orange, California, 92868, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.