One day of antibiotics may be enough after bone surgery
NCT ID NCT07554079
First seen May 20, 2026 · Last updated Jun 20, 2026 · Updated 4 times
Summary
This study looked at whether a one-day course of antibiotics is as good as a three-day course at preventing infections after femur or tibia fracture surgery with a metal rod (intramedullary nailing). Fifty-six adults were randomly assigned to receive either three or nine doses of cefuroxime after surgery. The goal was to see if shorter antibiotic use could safely reduce the risk of infection and antibiotic resistance.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dhulikhel Hospital, Kathmandu University Hospital
Dhulikhel, Bagmati, Nepal
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cefuroxime
What this could lead to
If a shorter antibiotic course works as well as a longer one, it could reduce antibiotic resistance and side effects for patients undergoing bone-nailing surgery.
What could go wrong
This is a small, single-center trial with only 56 participants, so results may not apply broadly. The study is also completed, so no new data is being collected.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.