University Hospital, Brest

This study tests whether a minimally invasive glue procedure (embolization) can prevent chronic subdural hematomas from coming back after standard care. About 550 adults with a brain bleed will receive either usual treatment alone or usual treatment plus the glue procedure. The g…

This study tests whether a shared decision-making process, which includes a personalized risk score, can help patients with a first unprovoked blood clot decide how long to continue blood thinners. The goal is to reduce the risk of another clot, major bleeding, and death, while i…

This study tests whether adding baricitinib (a JAK inhibitor pill) to standard steroid treatment helps people with polymyalgia rheumatica (PMR) achieve disease control without needing long-term steroids. About 140 adults aged 50+ with active PMR will receive baricitinib (2 mg or …

This study tests whether a nurse-led prevention program can reduce the burden of side effects in people starting long-term corticosteroid therapy. About 191 adults will either receive the nurse program or standard care. The goal is to see if the program lowers complications like …

This study is for people with knee osteoarthritis who are considering knee replacement surgery. It compares a complete medical treatment plan to surgery to see if the medical approach can work just as well for pain and function. The goal is to help patients avoid or delay major s…

This study tests whether giving botulinum toxin (like Botox) injections early to babies with a birth-related nerve injury can prevent shoulder deformity. About 62 babies aged 10-11 months will receive either the injection or a sham procedure. The goal is to see if the treatment k…

This study aims to develop a new radioactive tracer for PET scans that can directly detect active blood clots in veins. Current methods look for blockages indirectly, but this tracer targets a protein found in fresh clots. Researchers will test the tracer on blood samples from 10…

This study is testing a new type of PET/CT scan that uses a special tracer to see if it can better detect and monitor chronic inflammatory and fibrotic diseases like rheumatoid arthritis, liver fibrosis, and lupus. About 390 adults with these conditions will get the scan to measu…

This study is testing a new type of PET scan to see if it can tell the difference between cancer that is still there and swelling caused by radiation treatment in people with head and neck cancer. About 180 adults who finished radiation therapy will get this special scan 3 months…

This study looks at whether small changes in how people speak can predict if someone is about to develop schizophrenia. Researchers will record and analyze free speech from 215 people aged 15-30 who are at high risk. The goal is to create a tool that helps doctors catch the condi…

This study tests whether a special type of PET/CT scan (PSMA PET/CT) can more accurately detect if prostate cancer has spread to nearby lymph nodes in men with intermediate- or high-risk prostate cancer. About 159 men scheduled for prostate removal surgery will receive the scan b…

This study tests whether a green dye, injected during total thyroid removal surgery, helps surgeons see and protect the parathyroid glands. Damage to these glands can cause a lifelong need for calcium and vitamin D supplements. The trial will compare 242 patients who get the dye …

This study looks at whether giving blood thinners (LMWH) for 6 weeks after childbirth can prevent dangerous blood clots in women who have a moderate risk. About 2,400 women will be randomly assigned to receive either the blood thinner or standard care without it. The goal is to s…

This study compares two newer blood thinners (apixaban and rivaroxaban) against daily low-dose aspirin to prevent dangerous blood clots in people with JAK2-positive myeloproliferative neoplasms (blood cancers like polycythemia vera). About 1,300 high-risk adults (over 60 or with …

This study tests a program called PREVENTURE for teenagers aged 14 to 17 who are at risk for alcohol and drug addiction. Participants are randomly assigned to either the program plus usual care or usual care alone. The goal is to see if the program reduces binge drinking and othe…

This study tests whether naloxegol, a drug that blocks opioid side effects in the gut without affecting pain relief in the brain, can prevent constipation and pneumonia in brain-injured patients in the ICU. About 370 adults with traumatic brain injury or bleeding around the brain…

This study looks at whether a special parenting program can lower stress for parents who have alcohol use disorder and have children aged 4 to 12. About 90 parents will take part, and researchers will measure stress levels before and after the program. The goal is to see if the p…

This study tests whether personalized support from a sports and health professional after cardiac rehabilitation helps people with heart failure stay physically active for a full year. About 90 adults with stable heart failure will either receive this tailored follow-up or standa…

This study tests whether wearing Boarding Ring glasses can help people with vestibular neuritis (a sudden, severe dizziness caused by inner ear nerve inflammation) recover their balance more quickly. About 51 adults will wear the glasses and have their balance measured over a wee…

This study tests whether a capsaicin 8% patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for over 3 months after surgery or an injury. Half of the 46 participants will get the real patch, and the other half will get…

This study tests whether a nose spray made from treated seawater can shorten the time babies (1 month to 1 year) have symptoms of bronchiolitis, compared to a standard saltwater spray. About 458 infants with their first, mild-to-moderate bout of bronchiolitis will take part. Pare…

This study tests a mobile team of pain specialists who visit children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities. The team works with families and caregivers to assess and manage pain in the patient's usual …

This study looks at how a special PET/CT scan can show changes in lung function after pulmonary rehabilitation in people who still have shortness of breath after a pulmonary embolism. About 32 adults who are already in a larger rehab study will get two scans—one before and one af…

This study tests a French version of a questionnaire that measures the burden on people caring for a loved one with COPD. Researchers will ask 224 caregivers to fill out the questionnaire and compare it with other standard surveys. The goal is to provide a reliable tool to identi…

This study is looking at whether certain markers in the blood can help predict side effects from a type of cancer treatment called immune checkpoint inhibitors. Researchers will collect blood samples and health data from 200 cancer patients during their regular check-ups. The goa…

This study aims to find early signs that can tell if a first psychotic episode will develop into a mood disorder (like bipolar) or schizophrenia. Researchers will record speech during interviews and take blood samples from 217 people aged 15-30 who have had a first episode. They …

This study tests whether patients can wear a virtual reality (VR) headset during awake brain surgery to help them stay calm and complete thinking and language tests. First, the VR headset was tested on people having orthopedic surgery under local anesthesia to make sure it is saf…

This study looks at whether ultrasound images of the temporal and axillary arteries can help predict when giant cell arteritis (GCA) will flare up again. Researchers will follow 100 people with GCA to see if certain ultrasound patterns are linked to relapses. The goal is to impro…

This study looks at different types of B cells (a kind of immune cell) in the blood and gums of people with gum disease. Researchers want to see if certain B cells are linked to more severe disease and how they change after treatment. The goal is to improve diagnosis and personal…

This study looks at how often people with atopic dermatitis (eczema) experience itching from light touch, like clothing or a breeze. Researchers will survey 160 adults to measure this symptom and its impact on daily life. The goal is to better understand this understudied conditi…

This study looks at whether training paramedics with simulations can make brain tumor patients more satisfied with their care. About 250 adults with a newly discovered brain tumor will fill out a questionnaire after their hospital stay. The goal is to see if this training helps p…

This study looks at existing medical images to measure the muscles that move the eyes, the optic nerve, and the fat inside the eye socket. Researchers want to see how reliable these measurements are when different doctors look at the same images. The goal is to improve knowledge …

This study looks at 100 people getting a new heart valve through a tube (TAVI) to see if inflammation in the heart's electrical system causes rhythm problems. Researchers will use PET scans and ECGs to find clues that predict who might need a pacemaker. The goal is to avoid unnec…

This study looks at 50 people with chronic low back pain to see if simple movement tests used by physical therapists match what a high-speed camera captures. Participants perform six common tests while being filmed. The goal is to improve how we classify and treat different types…

This study follows 3400 people who have had a blood clot (venous thromboembolism) to see how often clots return and what raises the risk. It focuses on two groups: adults under 50, and people with active cancer at any age. Researchers will track participants for up to 5 years, no…

This study aims to understand why some women have a sensitive scalp—a condition that causes tingling, burning, or pain from everyday things like brushing hair or wearing a hat. Researchers will compare skin samples from 40 women (20 with a sensitive scalp and 20 without) to look …

This study is testing a secure app called Deneo Kid to see if it helps families and doctors better coordinate rehabilitation care for children and young people with neuromotor disabilities (like cerebral palsy or brain injury). About 20 children, their families, and their care te…

This study looks at 1,000 people who had a minor stroke to see if early information can predict their quality of life more than 4 years later. Participants fill out questionnaires and may give a saliva sample or have an MRI. The goal is to create a model that helps doctors unders…

This study aims to find genetic reasons why some women have repeated miscarriages or unexplained stillbirths. Researchers will compare 200 couples who have experienced these losses with healthy couples. The goal is to identify specific genetic differences that may cause these pre…

This study collects leftover epididymal tissue from men already scheduled for surgery to learn how the CFTR gene is regulated. Researchers aim to better understand male infertility linked to cystic fibrosis and related conditions. No extra procedures or health impacts are involve…

This study watches how preterm and full-term babies adapt to noises and lights (called habituation). Researchers want to see if early differences can predict later brain development. About 70 infants will be observed, but no treatment or medication is given.

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will collect and analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. Th…

This study is not testing a new drug or treatment. Instead, researchers are combining health information from 20,000 people across 14 European groups who have had blood clots (venous thromboembolism). By merging this data, they hope to better understand who is at risk for future …

This study looks at whether people aged 15 to 25 who are at risk for psychosis have trouble recognizing themselves and telling themselves apart from others. Researchers will compare them to healthy volunteers using a special mirror-and-window test. No treatment or medication is i…