Memorial Sloan Kettering Cancer Center

This study tests whether adding surgery and targeted radiation to standard treatment can cure HER2-positive breast cancer that has spread to a few places in the body (up to 5 spots). About 162 adults with this condition will be randomly assigned to either standard care alone or s…

This study tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). About 55 a…

This study is for people with advanced stomach, esophageal, or gastro-esophageal junction cancer that has spread or cannot be removed and has worsened after one prior treatment. Participants will receive a mix of immune cells (agenT-797) and several drugs (botensilimab, balstilim…

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can effectively control brain metastases in people with small cell lung cancer. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are al…

This study looks at whether adding a precise form of radiation (SRS) to the drug osimertinib is better than osimertinib alone for treating brain metastases in people with a specific type of lung cancer (NSCLC with EGFR mutation). About 56 adults who have at least one brain metast…

This study tests a drug called sacituzumab govitecan in 33 adults with mesothelioma that has returned or spread after prior treatment. Participants receive the drug until their disease worsens or side effects become too severe. The main goal is to see how many people's tumors shr…

This early-phase study tests whether giving deferoxamine directly into the spinal fluid is safe for people with leptomeningeal metastases (cancer spread to the brain and spinal cord lining). Researchers will find the highest dose with few side effects and then test it in more par…

This study tests whether a combination of three drugs (fianlimab, cemiplimab, and ipilimumab) can safely shrink or control advanced melanoma that no longer responds to standard PD-1 inhibitors. About 88 adults with unresectable stage III or IV melanoma will receive this treatment…

This study tests whether a special camera that shows blood flow in the bowel during surgery can lower the risk of dangerous leaks after ovarian cancer surgery. About 310 women having surgery for ovarian cancer will take part. The camera uses a glowing dye to help surgeons see pro…

This study tests if time-restricted eating (eating only during certain hours) plus coaching calls can help adult survivors of childhood cancer lose weight and lower their risk for heart disease and diabetes. About 300 survivors will either get coaching and a meal schedule or just…

This study tests whether the drug enfortumab vedotin can shrink or slow the growth of adenoid cystic carcinoma (ACC) that has spread or come back. About 34 adults with ACC will receive the drug and be monitored for tumor response and side effects. The goal is to find a better tre…

This study tests whether placing a small radiation device (Cs-131) into the brain during surgery can stop recurrent brain tumors from growing back. About 103 adults with previously treated brain metastases will be randomly assigned to get either standard surgery alone or surgery …

This study tests a new treatment for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. It combines special immune cells (CIML-NK cells) with a drug called atezolizumab. The goal is to find a safe dose and see if the combination can …

This study tests a combination of four drugs (CyBorD plus daratumumab) in 20 people with kidney disease caused by abnormal proteins from certain blood disorders. The goal is to see if the treatment is safe and can improve kidney function. Participants receive the drugs in cycles,…

This study is for people with osteosarcoma that has spread. It tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy works better than chemo alone. The trial involves 45 participants and also collects tumor samples to understa…

This study tests a drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD-1 and VEGF) to help the immune system fight the cancer. Researchers will check if the drug shrinks…

This study tests whether adding the immunotherapy drug pembrolizumab to chemotherapy drugs (melphalan and dactinomycin) delivered directly to the affected arm or leg can safely delay cancer growth. About 30 people with advanced or spreading sarcoma in a limb will take part. The g…

This study tests whether adding the drug certolizumab to standard chemotherapy and immunotherapy can shrink stage II-III lung cancers more effectively before surgery. About 60 adults with operable lung cancer will receive this combination. The goal is to see if reducing inflammat…

This study tests a drug called ASTX727 in people with a rare, aggressive nerve tumor (MPNST) that has a specific genetic change (PRC2 loss). The drug aims to stop cancer cells from growing. About 25 adults and teens whose cancer has worsened after standard treatment will take par…

This study tests whether a more aggressive approach to managing high blood pressure during breast cancer treatment is safer and more effective than standard care. Researchers want to see if it lowers blood pressure and reduces the risk of heart damage from chemotherapy. The trial…

This study is for people with HPV-positive throat cancer. It tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) to control cancer, while causing fewer side effects. About 121 participants will be e…

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Usually, after mastectomy, patients wait for radiation and then have delayed reconstruction. Here, doctors give radiation before surgery, so reconstruction can happen immediat…

This study tests a drug called pasireotide for people with prolactinomas (pituitary tumors that produce too much prolactin) who cannot take or do not respond to standard dopamine agonist therapy. About 10 adults will receive pasireotide to see if it can safely lower prolactin lev…

This early-stage study tests whether combining two drugs, teclistamab and mezigdomide, is safe and works for people with multiple myeloma that has come back or stopped responding to prior treatments. About 18 participants will receive the combination. The main goal is to check fo…

This study tests whether a cord blood transplant can help children and young adults (up to age 21) with life-threatening blood cancers or non-cancerous blood disorders who do not have a matched family donor. The main goal is to see how many patients are alive without treatment-re…

This study is testing a special camera that uses a laser to take detailed pictures of mouth sores before surgery. The goal is to see if these pictures can help doctors find oral cancer cells without needing a biopsy. About 140 people with mouth cancer will have their sores photog…

This study looks at whether starting sexual health counseling and using a non-hormonal moisturizer early can prevent or reduce vaginal dryness and sexual problems in premenopausal women with breast cancer who are receiving ovarian suppression. About 50 women will take part and be…

This study tests a new radiation technique called lattice radiation therapy (LRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT works better than standard radiation at shrinking tumors and helping the immune system attack cancer cells. A…

This study tests two different walking programs for women with breast cancer who are getting chemotherapy. One program has a fixed amount of walking each week, while the other adjusts the walking amount based on how the person responds. The goal is to see which approach better im…

This pilot study tests whether a buried fat flap (taken from the thigh) is safe and helpful for reducing neck problems like pain, stiffness, swelling, and trouble swallowing after head and neck cancer treatment. About 12 adults who need a second neck surgery after radiation will …

This study tests whether acupuncture is a practical way to treat period loss caused by chemotherapy in young women with cancer. About 60 participants aged 15 to 40 will receive acupuncture sessions, and researchers will track how many complete the treatment and whether their mens…

This study looks at how BRCA gene changes and cancer treatments impact the ovaries in premenopausal women with early-stage breast cancer. Researchers will measure hormone levels in the blood before, during, and after treatment to understand who is at higher risk for early menopau…

This study looks at how memory, attention, and thinking skills change over time in women aged 60-80 who are long-term breast cancer survivors, compared to healthy women of the same age. Researchers will use computer tests to measure mental function and also check if smoking histo…

This study looks at whether a special heart MRI (cardiac MRI) can help doctors understand blood clots that form in the right atrium of the heart due to central venous catheters (thin tubes placed in large veins for treatment). The goal is to learn more about these clots to guide …

This study looks at tiny particles called exosomes, which carry messages between cells, in the blood and tissue of people with pancreatic cancer. Researchers will compare these to samples from people with noncancerous pancreatic disease to establish normal values. The goal is to …

This study is testing a software tool that uses DNA from a blood sample to predict if a cancer patient's blood clot is likely to come back after stopping blood thinners. About 259 adults who have had a clot related to cancer and completed 3-12 months of blood thinner treatment wi…

This study is creating a registry of 300 people with Cushing's syndrome to follow their health before and after standard treatments like surgery, medication, or radiation. The goal is to collect real-world data on long-term outcomes. No experimental treatments are given; particip…

This study asks informal caregivers (family or friends) of people with Erdheim-Chester disease and similar conditions about their supportive care needs. Researchers will use a questionnaire to measure quality of life and identify areas where caregivers need more help. The goal is…

This study tests whether advanced MRI scans can better identify parts of a brain tumor that are likely to grow back after standard treatment. Researchers will use these scans to design more targeted radiation plans for about 135 adults with glioma. The goal is to see if this appr…

This study looks at whether new MRI and CT imaging techniques can help doctors better plan radiation therapy and check how tumors respond during treatment. About 837 adults will have extra scans, but their actual treatment will stay the same. The goal is to improve future care, n…

This study is testing a new breath test (called E-Nose) to see if it can measure how people with malignant pleural mesothelioma respond to standard treatment. Researchers will collect breath samples from 20 participants before and during treatment and compare the results with sta…

This study looks at how chemotherapy and radiation therapy affect the reproductive and sexual health of people diagnosed with colorectal cancer at a young age (under 40 for women, under 50 for men). Researchers will track hormone levels and sexual health over time to better under…

This study looks at whether exercise helps prevent cancer from coming back in adult cancer survivors. Researchers will review data from 1,000 people who have completed cancer treatment. They want to see if those who exercise have better outcomes, like longer time without the canc…

This study watches over 1,300 people with blood cancers like acute leukemia to see how many get a stem cell transplant and why some don't. It aims to find barriers that stop patients from receiving this treatment, even when doctors recommend it. No new treatments are tested—just …

This study looks at how genes and other factors affect breast cancer risk and outcomes in women from different backgrounds. Researchers will collect tissue and blood samples and have participants fill out questionnaires during their regular care. The study does not provide any tr…