Memorial Sloan Kettering Cancer Center

This study tests whether adding a chemotherapy drug (doxorubicin) to the standard drug sorafenib can help people with advanced liver cancer whose disease has worsened while on sorafenib alone. About 30 adults with confirmed liver cancer and good liver function are participating. …

This study looks at how safe and effective the diabetes drug glipizide is for lowering blood sugar in people with pancreatic cancer. About 29 adults with active pancreatic cancer and high blood sugar will take glipizide, and their glucose levels will be measured before and after …

This study tests two drugs, olaparib and pembrolizumab, given before standard surgery for people with triple-negative or hormone receptor-positive HER2-negative breast cancer who have specific gene mutations. The goal is to see if the combination shrinks the tumor enough to impro…

This study tests a daily pill called erdafitinib in 20 adults with a type of bladder cancer that has come back after standard treatments like BCG therapy. The cancer must have a specific change in the FGFR3 gene, which is common in these tumors. The pill blocks the faulty protein…

This study tests whether the drug anakinra can prevent or reverse severe side effects from CAR-T cell therapy, a powerful cancer treatment. About 62 adults with certain B-cell cancers (like leukemia or lymphoma) will receive anakinra alongside their CAR-T cells. The goal is to re…

This study tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) for people with HPV-positive throat cancer. The goal is to reduce side effects while still controlling the cancer. About 316 participan…

This study tests whether a combination of three drugs—cisplatin, nivolumab, and temozolomide—can shrink tumors in people with advanced colorectal cancer that has not responded to at least two prior treatments. The cancer must be mismatch repair-proficient (MMR-proficient), meanin…

This study looks at whether giving radiation only to the area where the cancer was removed (partial breast irradiation) for two weeks is safe and effective for women with early-stage breast cancer. About 110 women will receive this shorter treatment instead of the usual five to s…

This study tests whether the drug AG-120 can safely control tumor growth in people with advanced or recurrent chondrosarcoma, a rare bone cancer, that has a specific IDH1 gene mutation. Six adults with grade 2 or 3 disease are enrolled. The main goal is to see how long the cancer…

This study tests whether giving an early second infusion of tisagenlecleucel (a CAR T cell therapy) can keep B-cell aplasia (a sign of treatment effect) going for at least 6 months in children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. Ab…

This study looks at how long to wait between chemoradiation (chemotherapy plus radiation) and surgery for stage II or III rectal cancer. The goal is to find the best timing to shrink the tumor as much as possible and make surgery easier, while reducing complications. About 248 ad…

This study tests pembrolizumab, an immunotherapy drug, in 39 people with advanced adrenocortical carcinoma that cannot be removed by surgery. The goal is to see if the drug can shrink or control the cancer. Participants receive the drug for up to 24 months, and the study measures…

This early-phase study tested whether giving patients their own genetically modified immune cells (CAR T-cells) after high-dose chemotherapy and a stem cell transplant is safe for treating aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. Sev…

This study tests a drug called isatuximab for people whose blood cell counts stay low after a stem cell transplant for blood cancer. The goal is to see if it can help the body make enough healthy blood cells again. The trial involves 12 adults whose cancer is in remission but who…

This study tests whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) can safely stop treatment early if their cancer responds well. Instead of taking the drugs acalabrutinib and obinutuzumab continuously, participants who achieve deep remiss…

This study tests a new type of CAR T-cell therapy for adults with large B-cell lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to better target and kill cancer cells. The main goals are to find the safest dose and…

This study tests whether giving targeted radiation therapy alongside the immunotherapy drug avelumab can help control Merkel cell carcinoma that has spread and is no longer responding to standard treatment. About 18 adults with advanced, inoperable cancer will receive this combin…

This study looks at whether the number of stem cells given during a transplant affects how well the immune system recovers in people with relapsed or refractory diffuse large B-cell lymphoma. About 59 adults who have already tried one chemotherapy and are eligible for a stem cell…

This study tests a new two-drug combination (MEK162 plus imatinib) for people with advanced gastrointestinal stromal tumor (GIST), a rare stomach or intestinal cancer. The goal is to find the safest dose and see if the combo shrinks tumors better than standard treatment. The stud…

This study tests whether adding two experimental vaccines (IO102/IO103) to the standard drug combination of nivolumab and relatlimab is safe and works better for people with advanced melanoma that cannot be removed by surgery. About 43 adults who have not had prior treatment for …

This study tests a treatment for people with certain types of leukemia or lymphoma that have come back or not responded to standard chemotherapy. The approach takes a patient's own immune cells (T cells), modifies them in the lab to target a protein called CD19 found on cancer ce…

This study tests a special dye called PARPi-FL that makes oral cancer cells glow. The goal is to see if it's safe and helps surgeons find and remove all cancer during surgery. About 23 adults with oral squamous cell carcinoma will take part.

This study checks if a special MRI-guided biopsy can accurately tell if breast cancer has been completely wiped out by chemotherapy. About 31 women whose tumors no longer show on MRI will get this biopsy. If it works, some women might not need breast surgery in the future.

This early-phase study tests whether injecting a radioactive sugar (18F-FDG) into the cervix before a PET/CT scan can better show which pelvic lymph nodes contain cancer. About 42 women with stage IB1 cervical cancer or high-grade endometrial cancer will receive the injection bef…

This study adapts a type of counseling called Meaning-Centered Psychotherapy for Chinese immigrants with advanced cancer. The goal is to help patients maintain a sense of meaning and purpose in life despite their illness. Researchers will interview and test the adapted therapy wi…

This study tests whether adding acupuncture to standard pain care can reduce the need for strong opioid painkillers in people with multiple myeloma, Hodgkin disease, or non-Hodgkin lymphoma who are getting high-dose chemotherapy. About 299 adults will be randomly assigned to rece…

This study tests whether a pelvic floor muscle exercise program, taught by a physical therapist before and after prostate removal surgery, can help prevent or shorten urine leakage. Researchers will track how many of the 32 participants stick with the program and report their sat…

This study tests a memory training program for breast cancer survivors who have memory problems after chemotherapy. About 60 women who finished chemo 1-10 years ago will use either a challenging or easier version of a computer program called Cogmed. The goal is to see if the trai…

This study looks at whether using an interactive 3D tool during a surgical consultation helps women with breast cancer feel more satisfied with the information they receive about breast reconstruction options. About 88 women planning mastectomy will be involved. The goal is to se…

This study tests whether giving a precise, high-dose form of radiation (SBRT) within a week before surgery for bone metastases is safe and effective. It includes 39 adults with cancer that has spread to the bone and who are at risk of a fracture. The goal is to see if this approa…

This study tests whether an oral minoxidil pill can safely improve hair loss in children and young adults who had cancer treatment. Ten survivors aged 6-18 who finished cancer therapy at least a year ago will take the drug. Researchers will measure hair regrowth and check for sid…

This study looks at whether giving methadone during spinal surgery for cancer patients can reduce pain and the need for extra painkillers in the first three days after surgery. About 17 adults having spinal surgery will be randomly assigned to receive either methadone or standard…

This study compares two types of radiation therapy for people with head and neck cancer: proton beam and standard photon (IMRT). The goal is to see if proton therapy reduces side effects like painful mouth sores by exposing less healthy tissue to radiation. About 108 adults with …

This study explores whether routine brain scans and spinal fluid tests can detect early signs of brain cancer in people with HER2-positive breast cancer. Researchers aim to see if these tests are practical and can help start treatment sooner. The study involves about 9 participan…

This study trains doctors, nurses, and other cancer care providers in a special type of talk therapy called Meaning-Centered Psychotherapy (MCP). The goal is to help these clinicians better support cancer patients' emotional and spiritual needs. About 350 providers will take part…

This study looks at why some people with relapsed or hard-to-treat multiple myeloma do not receive advanced cell therapies like stem cell transplants or CAR T-cell therapy. Researchers will track referral rates and gather information from both patients and their doctors. The goal…

This study looks at DNA from over 21,000 people with different cancers (like breast, colon, and lung) to find inherited gene changes that might be linked to cancer. It is an exploratory project that does not offer treatment, but aims to generate new ideas for future research. Par…

This study looks at how the chemotherapy drug cisplatin may damage blood vessels in men with germ cell tumors. Researchers will measure blood vessel function in patients receiving cisplatin and compare it to those who had surgery only. The goal is to understand why cisplatin migh…

This study looks at whether a newer biopsy method called transbronchial cryobiopsy (using a freezing tool) is safer than the standard method for taking lung tissue samples. About 100 adults with known or suspected cancer will take part. The goal is to see if this technique causes…

This study looks at the experiences and needs of 160 parents who lost a child to cancer between 6 months and 6 years ago. Researchers want to understand what helps parents find meaning after their loss. The goal is to use this information to create a program that can better suppo…

This study looks at how lung cancer patients and their doctors communicate during appointments. Researchers want to understand how these conversations affect patient well-being and outcomes. About 294 patients will take part, sharing their experiences through interviews and quest…

This study looks at whether tooth enamel loss (dental erosion) can be a simple, non-invasive clue for esophagogastric cancer and other cancers like colorectal, pancreatic, breast, head and neck, and lung cancer. Researchers will compare dental erosion in 174 people with and witho…

This study is being done to test whether receiving a dose of radiation that is higher than the standard dose, in combination with chemotherapy, improves the chance of becoming a candidate for surgery and improves the chance of extending the patient's life.