Memorial Sloan Kettering Cancer Center

This study tests whether adding the immunotherapy drug nivolumab to radiation and another drug called bevacizumab can help people with a returning type of brain cancer called glioblastoma. The trial includes 39 adults whose tumors have a specific genetic marker (MGMT methylated) …

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to bone tumors within a week before surgery is safe and helps prevent the cancer from returning. It involves 39 adults with cancer that has spread to the bone and who need surgery to stabilize a weake…

This study tests whether adding the drug Voraxaze (glucarpidase) to the standard treatment for central nervous system lymphoma can safely lower methotrexate levels in the blood. About 58 adults with B-cell lymphoma in the brain or spine are taking part. The goal is to reduce side…

This study is for people with Merkel cell carcinoma that has spread or can't be removed by surgery and has gotten worse after initial treatment. It tests whether giving a type of focused radiation (CART) together with the immunotherapy drug avelumab can help control the cancer. T…

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or slow the growth of advanced salivary gland cancers that have returned or spread. About 64 adults with adenoid cystic carcinoma or other salivary gland cancers are taking part. The goal is to see how w…

This study tests whether combining two drugs, rucaparib and nivolumab, can treat advanced or metastatic leiomyosarcoma (LMS) better than standard chemotherapy. About 20 adults with LMS that cannot be removed by surgery or has spread will receive the combination. The goal is to se…

This study tests the safety of adding two immunotherapy drugs, durvalumab and tremelimumab, to standard chemotherapy and radiation for people with esophageal or gastroesophageal junction cancer. About 64 participants will receive initial chemotherapy followed by the drug combo wi…

This study tests whether giving palifermin and leuprolide acetate after a stem cell transplant can help the immune system bounce back more quickly. About 82 adults with blood cancers like leukemia or lymphoma will receive these drugs alongside standard transplant care. The goal i…

This study tested whether adding the targeted drug cetuximab to standard chemotherapy could shrink advanced thymoma or thymic carcinoma tumors before surgery. 18 adults with stage II to IVA disease received the combination, then had their tumors removed. Researchers measured how …

This study tests the safety and effectiveness of the drug pembrolizumab in preventing cancer from returning. It includes 17 adults with MSI-H solid tumors who had surgery but still have tumor DNA in their blood. Participants receive pembrolizumab or a placebo for up to 12 months,…

This study is testing if a drug called anakinra can prevent or reduce severe brain-related side effects and dangerous immune reactions in adults receiving CAR-T cell therapy for certain B-cell cancers. The goal is to make this powerful cancer treatment safer by controlling its mo…

This study looks at whether the number of stem cells given during a transplant helps the immune system recover faster in people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). About 59 adults who have already had some chemotherapy will receive high-dose therapy…

This study tests a daily pill called erdafitinib in 20 adults whose non-muscle invasive bladder cancer has returned after standard treatments like BCG or chemotherapy. Only people whose tumors have a specific FGFR3 gene change can join. The pill blocks the faulty protein made by …

This early-phase study tests whether a personalized cancer vaccine, made from a patient's own tumor, combined with an immunotherapy drug (atezolizumab) and chemotherapy is safe for people with pancreatic cancer that has been surgically removed. About 29 adults with resectable pan…

This study tests a shorter radiation treatment called partial breast irradiation (PBI) for women with early-stage breast cancer. Instead of treating the whole breast for 5-7 weeks, PBI targets only the area where the tumor was removed, given daily for 2 weeks. The goal is to see …

This study tests whether adding the drug CC-486 to standard lenalidomide and radiation therapy is safe and works better for people with plasmacytoma, a rare blood cancer that can turn into multiple myeloma. About 21 adults with newly diagnosed or returning plasmacytoma will recei…

This study tests the safety of a drug called RP-3500 when given with radiation therapy to people whose metastatic solid tumors have a specific gene change (ATM mutation). About 49 adults with advanced cancer that has spread will take part. The goal is to find the best dose that c…

This study tests whether the immunotherapy drug pembrolizumab can shrink early-stage NK/T-cell lymphoma in people who have not yet had chemotherapy. Nineteen adults with this rare nasal lymphoma will receive pembrolizumab and be monitored for tumor response. The goal is to see if…

This early-stage study tests a new treatment called MCARH109 for people with multiple myeloma that has come back or not responded to at least three prior treatments. The therapy uses specially modified immune cells to target a protein on myeloma cells. The main goal is to find th…

This study tests whether combining two drugs, glofitamab and lenalidomide, can help people with mantle cell lymphoma that has returned or stopped responding to prior treatments, including a BTK inhibitor. About 39 adults will take part. The goal is to see if the treatment is feas…

This study tests an experimental treatment called HB-200 for people with HPV16-positive head and neck cancer who have completed standard therapy but still show cancer-related DNA in their blood (detected by a special test). The goal is to see if HB-200 can control or eliminate an…

This study tests whether the drug pembrolizumab can shrink or stop the growth of recurrent malignant gliomas, a type of aggressive brain cancer. The drug works by activating the immune system to attack cancer cells. The trial enrolled 27 adults whose tumors have returned after pr…

This study tests whether giving a personalized dose of a drug called r-ATG before a stem cell transplant can help the immune system recover faster and reduce serious side effects. It includes children and adults with acute leukemia or myelodysplastic syndrome (MDS) receiving a do…

This study adapts a type of counseling called Meaning-Centered Psychotherapy for Chinese immigrants with advanced cancer. The goal is to help patients maintain a sense of meaning and purpose in life despite their illness. Researchers will interview and test the adapted program wi…

This study looks at whether giving siltuximab before and after an autologous stem cell transplant can reduce common side effects like fatigue, pain, and nausea in patients aged 60-75 with multiple myeloma or AL amyloidosis. The drug blocks a protein called IL-6 that is linked to …

This early-phase study tests whether adding N-acetylcysteine (N-AC) to standard CAR T-cell therapy (Yescarta) is safe for people with lymphoma. Researchers aim to find the highest dose of N-AC that causes few or mild side effects. Nine adults with lymphoma who are already schedul…

This study tests a new imaging tool called MSOT that uses light and sound to create pictures of tumors. About 12 people with breast cancer or melanoma will get an MSOT scan before their usual biopsy. The goal is to see if MSOT can find tumors as well as standard methods like ultr…

This study measures how cisplatin chemotherapy affects the inner lining of blood vessels (endothelium) in men with germ cell tumors. It compares 44 participants: those receiving cisplatin and those who had surgery only. The goal is to understand why cisplatin may increase long-te…

This study looks at how different antibiotics change the community of helpful bacteria in the gut of people who have received a stem cell transplant. These patients often develop fever and low white blood cell counts, requiring antibiotics. The goal is to understand which antibio…

This study looks at why some people with relapsed or hard-to-treat multiple myeloma do not receive advanced cell therapies like stem cell transplants or CAR T-cell therapy. Researchers will track referral rates and gather information from both patients and their doctors. The goal…

This study looks at how prostate cancer survivors' thinking and memory (called cognitive function) may be linked to other issues like anxiety, depression, and trouble sleeping. Researchers will also examine how social factors, cancer details, and treatments might play a role. Abo…

This study looks at how surviving a pediatric brain tumor affects children's thinking, memory, and behavior. Researchers will follow 42 children who have completed treatment for certain brain tumors. The goal is to learn more about the long-term effects of cancer and its treatmen…

This study uses a tiny amount of a radioactive tracer called 124I-PUH71 to take PET scans of cancer patients. The goal is to see where the tracer goes in the body and how long it stays in the blood. This information will help researchers plan future studies using higher doses of …

This early-phase study tests whether a special PET scan using an experimental tracer called 18F-FAC can show how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 adults with pancreatic cancer will receive the tracer before starting tre…

This study looks at how regular exercise might change the biology of breast tumors in 42 women with early-stage breast cancer. Researchers will compare tumors from women who exercise regularly with those who do not, focusing on genetic and immune system differences. The goal is t…

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that makes the body burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer. Nineteen participants will follow the diet before their surgery. The m…

This study looks at how the bacteria naturally living in the gut and diet may influence colorectal cancer risk in people with Lynch syndrome or other inherited colon polyp conditions. Researchers will collect stool samples, colon tissue, and diet/lifestyle questionnaires from 77 …