Memorial Sloan Kettering Cancer Center

This study looks at whether a blood test that detects tumor DNA (ctDNA) can help doctors decide if it's safe to stop maintenance immunotherapy after one year in people with advanced or recurrent endometrial cancer. About 30 participants will receive standard chemotherapy plus imm…

This study tests whether adding the drug pembrolizumab to standard chemotherapy (GVD) can improve outcomes for people with Hodgkin lymphoma that has returned or not responded to initial treatment. About 257 participants will receive the combination, and those who respond well may…

This study tests a new radioactive drug, 177Lu-PSMA-617, to see if it is safe for people with a fast-growing type of brain tumor called IDH wild type glioma. The drug targets a protein (PSMA) found on these tumor cells and delivers radiation directly to them. About 20 adults whos…

This study compares a new boost technique called irreversible electroporation (IRE) to the standard radiation boost for men with intermediate-risk prostate cancer. About 224 participants will receive standard stereotactic body radiotherapy plus either IRE or a radiation boost. Th…

This study tests whether two immunotherapy drugs, botensilimab and balstilimab, can shrink or eliminate locally advanced rectal tumors that are mismatch repair proficient (MMRp/MSS). About 40 adults with stage II or III rectal cancer will receive the drugs before standard chemoth…

This study looks at whether a more aggressive approach to managing high blood pressure during breast cancer treatment is safer and better at lowering blood pressure and reducing heart damage than the usual approach. About 130 women with breast cancer and high blood pressure will …

This study tests if a procedure called gastric preconditioning, done before esophageal cancer surgery, can lower the chance of a dangerous leak where the stomach is reconnected to the esophagus. It is for people at high risk of this leak. The procedure uses a tiny tube to block s…

This study tests a new way to prepare people with sickle cell disease or beta-thalassemia for a stem cell transplant from a half-matched donor. Before the transplant, patients receive drugs to lower their immune system, which may help prevent serious side effects like graft failu…

This early-stage study is testing a new drug called 2141-V11 in people with a type of bladder cancer that hasn't improved with standard treatment. The drug is given directly into the bladder through a thin tube. The main goal is to find the safest dose and see how the body handle…

This study tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). About 55 p…

This study is for children with high-risk neuroblastoma whose cancer is in complete remission. It tests a bivalent vaccine (with an immune booster) plus an oral beta-glucan supplement to see which schedule of beta-glucan works best to keep the cancer from returning. About 94 part…

This study tests whether pembrolizumab, a drug that helps the immune system attack cancer, can shrink tumors in people with ultra-rare sarcomas. About 32 adults with specific rare sarcoma types that have come back or spread will receive the drug. The goal is to see if the treatme…

This study tests whether combining two drugs, abemaciclib and cabozantinib, is safe and effective for people with advanced kidney cancer that has not responded to immunotherapy. About 43 adults with clear cell or translocation renal cell carcinoma will receive different doses to …

This study tests whether sotorasib is safe and effective as the first treatment for people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. Participants have not yet received any treatment for their advanced cancer. The study will monitor tumor res…

This study is for people with metastatic cancer that has spread and who have a specific gene change called an ATM mutation. Researchers want to see if a lower dose of radiation can still control the tumor, which might mean fewer side effects. About 40 adults will take part, and t…

This early-phase study tests an experimental cell therapy called MB-CART19.1 for people with central nervous system lymphoma (CNSL) that has returned or not responded to prior treatments. The therapy uses a patient's own immune cells, modified to target cancer, and is made on-sit…

This study tests whether the drug Vonescimab can safely shrink or control advanced leiomyosarcoma, a rare soft-tissue cancer. About 20 adults who have already tried 1-3 prior treatments will receive the drug. The goal is to see if it slows tumor growth with few side effects.

This early-phase trial tests a new drug called CRD3874-SI in people with advanced solid tumors like sarcoma and Merkel cell carcinoma. The main goal is to find the safest dose and see if it can shrink tumors. About 72 participants will receive the drug to check for side effects a…

This early-phase study is testing whether combining two targeted drugs (gilteritinib plus ivosidenib or enasidenib) is safe and helpful for adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. The participants have specific gene changes (FLT3…

This early-stage study tests whether a new imaging tracer, made of tiny silica nanoparticles, can safely help find prostate cancer cells before and during surgery. About 16 men with high-risk prostate cancer will receive the tracer and then have PET/MRI scans and special camera i…

This study adapts a counseling approach called Meaning Centered Psychotherapy to better support Latinos with advanced cancer. Researchers will test if this culturally tailored program improves spiritual well-being and reduces anxiety and depression. About 190 adults with stage II…

This study tests whether a buried fat flap procedure is safe and helpful for people who have neck problems like pain, stiffness, swelling, or trouble swallowing after radiation and surgery for head and neck cancer. About 12 adults who need a salvage neck dissection will receive t…

This study adapts a counseling program called Meaning Centered Psychotherapy to better support Latinos with advanced cancer. Researchers want to see if this culturally tailored approach can improve quality of life and reduce emotional distress. About 285 adults with stage III or …

This study tests whether a virtual mind-body program called Integrative Medicine at Home (IM@Home) can reduce fatigue and improve well-being in adults with head/neck, thoracic, gynecologic, or melanoma cancers. Participants will receive the program while undergoing treatments lik…

This study tests whether shining a special light (photobiomodulation) inside the mouth can safely ease painful sores from chronic graft-versus-host disease, a common complication after a stem cell transplant. About 44 people aged 4 and older who have mouth sores that didn't impro…

This study looks at gene changes (mutations) in cancer cells from people with solid tumors or blood cancers. Researchers use leftover tumor tissue from past surgeries or biopsies, plus a blood or saliva sample, to find mutations that might affect how a cancer responds to treatmen…

This study aims to understand the genetic and biochemical makeup of neuroblastic tumors, which can affect how aggressive the cancer is and what treatments work best. Researchers will analyze tumor samples, blood, bone marrow, and stem cells from over 2000 participants. The goal i…

This study is working on a simple test to find pancreatic cancer at an early stage and to see how well treatment is working. Researchers will study blood and tissue samples from 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to improve early det…

This study collects health information from people of any age who have desmoplastic small round cell tumor (DSRCT), a rare cancer. The goal is to build a database that researchers can use to better understand the disease and improve future care. Participants simply agree to share…

This study is a registry that collects information from 100 adults with thyroid cancer that no longer responds to standard radioactive iodine treatment. Doctors are using redifferentiating medications as part of normal care to try to make the cancer respond to radioactive iodine …

This study follows 300 people who had surgery to remove a bone tumor and then had the bone rebuilt with a graft or artificial device. Researchers will measure how much function returns and how well the bone heals over three years. The goal is to understand recovery patterns and i…

This study is building a registry of people with early changes in the stomach lining that can lead to stomach cancer. Researchers will track these changes and look for risk factors to better understand how to prevent cancer. The study enrolls adults aged 18 and older who have the…

This study aims to develop and test a communication training program called Hematolo-GIST for doctors who treat large B-cell lymphoma. The goal is to help doctors better discuss the diagnosis and plan future care with their patients. The study will enroll 48 participants, includi…

This study creates a registry of DNA and health information from people with germ cell or testicular tumors, their blood relatives, and unrelated volunteers. By comparing these groups, researchers hope to learn why some people develop these tumors and others don't. The goal is to…

This study tests whether teaching oncology doctors, nurses, and physician assistants empathic communication skills can reduce the stigma lung cancer patients often feel during medical visits. Over 1,200 healthcare providers from across the U.S. will participate in training sessio…

This study tests whether a special ultrasound (mpUS) can measure changes in vaginal tissue caused by internal radiation therapy (IVRT) for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method can detect side effects like …

This study follows 600 people with early-stage lung cancer who have a type of surgery called segmentectomy. Participants fill out questionnaires before surgery, a few weeks after, and 6 months after. The goal is to see how long people stay cancer-free after the procedure.