Eli Lilly And Company

This study tests whether the drug selpercatinib can delay the return of lung cancer in people with early-stage non-small cell lung cancer (NSCLC) that has a specific genetic change (RET fusion). Participants have already had surgery or radiation to remove or treat their cancer. T…

This study tests a drug called lebrikizumab in children aged 6 months to 18 years with moderate-to-severe eczema (atopic dermatitis). The goal is to see if it improves skin symptoms and itching compared to a placebo. About 367 participants will receive injections over several wee…

This study looks at the long-term safety of the drug pirtobrutinib in people with certain blood cancers, like chronic lymphocytic leukemia or non-Hodgkin lymphoma. It includes 13 participants who already completed an earlier study and are still benefiting from the treatment. They…

This study tests whether adding the drug abemaciclib to standard chemotherapy can help children and young adults with Ewing's sarcoma that has returned or not responded to treatment. About 46 participants will receive either the drug combo or chemo alone. The goal is to see if th…

This study tests whether adding the drug ramucirumab to standard chemotherapy can help children and young adults with a rare cancer called desmoplastic small round cell tumor (DSRCT) that has returned or not responded to prior treatment. About 30 participants will receive either …

This study tests whether adding a weight-loss drug (tirzepatide) to a standard psoriasis drug (ixekizumab) helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 250 adults will receive either ixekizumab alone or both drugs together for up t…

This study tests an experimental drug called LY3871801 in 164 adults with moderate-to-severe rheumatoid arthritis (RA). Participants will receive either the drug or a placebo to see if it reduces joint pain and swelling. The goal is to find a new treatment option for people who h…

This study tests an oral drug called baricitinib in children aged 2 to 18 with active uveitis linked to juvenile idiopathic arthritis or a related antibody-positive condition. The goal is to see if the drug safely reduces eye inflammation. About 30 participants will receive baric…

This study looks at whether adding tirzepatide (a weight-loss drug) to ixekizumab (a treatment for psoriatic arthritis) helps people with both conditions. About 279 adults with active psoriatic arthritis and obesity or overweight will take part. The goal is to see if the combinat…

This study tests whether adding ramucirumab to the standard drug erlotinib helps people with a specific genetic type of advanced lung cancer (EGFR mutation-positive) live longer without their cancer growing. About 545 people who have not had prior treatment will receive either th…

This large Phase 3 study tests an investigational drug called lepodisiran in about 17,300 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease and stroke. Participants either already have heart disease or are at high risk for a first heart attack or …

This study tests an oral drug called selpercatinib in 77 people in China who have advanced solid tumors or medullary thyroid cancer with a specific RET gene change. The main goal is to see if the drug can shrink tumors and how safe it is. Participants take the drug daily and are …

This study tests whether galcanezumab, a monthly injection, can safely reduce the number of migraine days in teenagers aged 12 to 17 who have chronic migraine (15+ headache days per month). Over 300 participants receive either the drug or a placebo for 3 months. The main goal is …

This study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years are participating. The goal is to reduce joint inflammat…

This early-stage study tests an experimental drug called LY3484356 in 17 Chinese patients with a specific type of advanced breast cancer (ER+/HER2-). The main goal is to see how the drug moves through the body and how safe it is. Researchers will also check if the drug can shrink…

This program monitors 4,000 people with schizophrenia who receive the injectable medication Zyprexa Relprevv. The goal is to track and reduce the risk of a rare but serious side effect called post-injection delirium/sedation syndrome (PDSS). Researchers will record how often PDSS…

This study tests a radioactive drug called [Ac-225]-PSMA-62 in men with PSMA-positive prostate cancer that has spread. The goal is to find the safest and most effective dose, and to see if it can control the cancer. About 142 men with hormone-sensitive or castration-resistant pro…

This study tests whether adding the drug abemaciclib to standard chemotherapy (temozolomide) helps children and young adults with a fast-growing brain tumor called high-grade glioma. About 45 participants will receive either the combination or chemotherapy alone after radiation. …

This study tests whether different doses of the investigational drug tirzepatide can help people with type 2 diabetes and obesity lose weight and improve blood sugar control. About 414 adults who are already taking metformin will receive either tirzepatide or a placebo for up to …

This study tests whether a targeted drug called selpercatinib works better than standard chemotherapy for people with a specific type of advanced lung cancer (RET fusion-positive non-small cell lung cancer). About 261 participants will receive either selpercatinib or standard tre…

This study tests whether mirikizumab can reduce the sudden, urgent need to have a bowel movement in adults with moderate-to-severe ulcerative colitis. About 172 participants will receive the drug for 36 weeks. The main goal is to see if urgency severity and frequency improve.

This study looks at how well three different tablet versions of the drug LY4100511 are absorbed into the body. It also checks if taking a common stomach acid medication changes absorption. The study involves 48 healthy adults and is not intended to treat any disease.

This early-stage study tests whether a single dose of remternetug is safe in 24 healthy Chinese adults. Participants receive the drug under the skin and are monitored for side effects and how the drug moves through the body. The study lasts up to 25 weeks and does not aim to trea…

This study looks at how fasting and temporarily stopping the diabetes drug dulaglutide affect what stays in the stomach after a meal. About 20 people with type 2 diabetes will have their stomachs checked with ultrasound after eating. The goal is to understand how these factors in…

This early-stage study looks at how a new medicine called LY3537031 moves through the body when injected under the skin in different areas or into a vein. It involves 46 healthy adults and focuses on drug levels in the blood and safety. The goal is to learn how the injection site…