New drug shows promise for stubborn hand and foot eczema in phase 3 trial

NCT ID NCT06921759

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called lebrikizumab against a placebo in 221 adults and teenagers with moderate-to-severe hand and foot eczema. The treatment is given as an injection under the skin over 16 weeks. The main goal is to see if the drug can clear or nearly clear the skin rash and reduce itch better than a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lebrikizumab (a drug given as an injection under the skin)
What this could lead to: If it works, this could provide a new treatment option for people with stubborn hand and foot eczema that hasn't responded to other therapies.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects like injection reactions or infections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC HAND AND FOOT DERMATITIS

Contacts and locations

Locations

Ajou University Hospital

Suwon, 16499, South Korea
Arké SMO S.A de C.V

Veracruz, 91900, Mexico
Asan Medical Center

Seoul, 05505, South Korea
CIPREC

Buenos Aires, C1061AAS, Argentina
CONEXA Investigacion Clinica S.A.

Buenos Aires, 1012, Argentina
CaRe Clinic

Red Deer, T4P 1K4, Canada
Care Access - Hoboken

Hoboken, New Jersey, 07030, United States
Centre de Recherche Saint-Louis

Montreal, H1Y 3L1, Canada
Centre de Recherche Saint-Louis

Québec, G1W 4R4, Canada
Centro de Investigaciones San Miguel

San Miguel, 1663, Argentina
Chang Gung Medical Foundation-Linkou Branch

Taoyuan, 333, Taiwan
Chang Gung Memorial Hospital at Kaohsiung

Kaohsiung Niao Sung Dist, 83301, Taiwan
Chosun University Hospital

Gwangju, 61453, South Korea
Complete Dermatology

Sugar Land, Texas, 77479, United States
Cornerstone Dermatology

Coorparoo, 4151, Australia
Cryptex Investigación Clínica S.A. de C.V.

Cuauhtémoc, Ciudad de México, 06100, Mexico
DeNova Research

Chicago, Illinois, 60602, United States
DermEffects

London, N6H 5L5, Canada
Dermatology Research Associates

Los Angeles, California, 90045, United States
Dermatology and Ophthalmology Kume Clinic

Sakai, 593-8324, Japan
Encore Medical Research

Hollywood, Florida, 33024, United States
Eukarya Pharmasite S.C.

Monterrey, 64718, Mexico
FACET Dermatology

Toronto, M4E 1R7, Canada
First OC Dermatology Research Inc

Fountain Valley, California, 92708, United States
Fremantle Dermatology

Fremantle, 6160, Australia
Fundacion Estudios Clinicos

Rosario, 2000, Argentina
Fundación Respirar

Buenos Aires, C1426ABP, Argentina
INECO Neurociencias Oroño

Rosario, 2000, Argentina
INTERMED Groupe Sante

Chicoutimi, G7H 7Y8, Canada
Institute for Skin, Health and Immunity

Mitcham, 3132, Australia
Instituto de Investigaciones Clinicas Rosario

Rosario, S2000CVD, Argentina
Instituto de Neumonologia Y Dermatologia

Buenos Aires, C1425BEA, Argentina
Interior Dermatology Centre - Probity - PPDS

Kelowna, V1W 4V5, Canada
Investigaciones Medicas Imoba Srl

Buenos Aires, C1056ABH, Argentina
Kohler & Milstein Research S.A. De C.V.

Mérida, 97070, Mexico
Konkuk University Medical Center

Seoul, 05030, South Korea
Korea University Ansan Hospital

Ansan-si, 15355, South Korea
Kosugi Dermatology Clinic

Kawasaki-shi, 211-0063, Japan
Kyung Hee University Hospital at Gangdong

Seoul, 05278, South Korea
Kyungpook National University Hospital

Junggu, 41944, South Korea
Maruyama Dermatology Clinic

Kōtoku, 136-0074, Japan
MediSearch Clinical Trials

Saint Joseph, Missouri, 64506, United States
National Cheng Kung University Hospital

Tainan, 704, Taiwan
National Taiwan University Hospital

Taipei, 10002, Taiwan
National Taiwan University Hospital - Hsinchu branch

Zhubei, 302, Taiwan
New Taipei Municipal TuCheng Hospital

New Taipei City, 236, Taiwan
Optima Research - Boardman

Boardman, Ohio, 44512, United States
Pansy Skin Clinic

Saitama, 330-0064, Japan
Paratus Clinical Research Woden

Phillip, 2606, Australia
Parra Dermatología

Mendoza, 5500, Argentina
Private Practice - Dr. Rachel Asiniwasis

Regina, S4V 1R9, Canada
Progressive Clinical Research

San Antonio, Texas, 78213, United States
Psoriahue

Buenos Aires, C1425DKG, Argentina
Pusan National University Yangsan Hospital

Busan, 50612, South Korea
Renstar Medical Research

Ocala, Florida, 34470, United States
Research Associates of South Florida - Miami - Southwest 8th Street

Miami, Florida, 33134, United States
Revival Research Institute, LLC

Troy, Michigan, 48084, United States
Scientia Investigacion Clinica S.C.

Chihuahua City, 31203, Mexico
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
SimcoDerm Medical and Surgical Dermatology Center

Barrie, L4M 7G1, Canada
Skin Health Institute Inc.

Carlton, 3053, Australia
Southern Indiana Clinical Trials

New Albany, Indiana, 47150, United States
St George Dermatology & Skin Cancer Centre

Kogarah, 2217, Australia
Tachikawa Dermatology Clinic

Tachikawa, 190-0023, Japan
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Tanpopo Skin Clinic

Ōta-ku, 143-0023, Japan
Texas Dermatology and Laser Specialists

San Antonio, Texas, 78218, United States
The Catholic Univ. of Korea Seoul St. Mary's Hospital

Seoul, 06591, South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital

Bupyeong-gu, 21431, South Korea
The Skin Centre

Benowa, 4217, Australia
Tokyo Medical University Hospital

Shinjuku-ku, 160-0023, Japan
Tri-Service General Hospital

Taipei, 114, Taiwan
University Hospital,Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan
Veracity Clinical Research

Woolloongabba, 4102, Australia
Wiseman Dermatology Research Inc.

Winnipeg, R3M 3Z4, Canada