New daily pill aims to tackle both high blood pressure and excess weight

NCT ID NCT06948435

First seen Nov 01, 2025 · Last updated Jun 13, 2026 · Updated 31 times

Summary

This phase 3 trial tests a once-daily medication called orforglipron in about 487 adults who have both high blood pressure and obesity or overweight. The study measures how well the drug lowers blood pressure and body weight compared to a placebo. Participants take the pill daily and are monitored for safety and effectiveness over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AHEPA University General Hospital of Thessaloniki

    Thessaloniki, 546 36, Greece

  • Advanced Research Institute

    Ogden, Utah, 84405, United States

  • Advanced Research Institute - Tigard

    Tigard, Oregon, 97223, United States

  • All India Institute of Medical Sciences

    Bhubaneswar, 751019, India

  • AmBeNet GmbH

    Leipzig, 04107, Germany

  • Angiocentrum Komorany

    Prague, 143 00, Czechia

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098, United States

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229, United States

  • Ashirwad Hospital and Research Centre

    Ulhasnagar, 421004, India

  • Athens Medical Center - Psychikon branch

    Athens, 115 25, Greece

  • Balsam Medica

    Warsaw, 01-249, Poland

  • Beijing Pinggu District Hospital

    Beijing, 101200, China

  • CCR Ostrava s.r.o

    Ostrava, 702 00, Czechia

  • CEMEDIC

    Buenos Aires, C1407GTN, Argentina

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, 15001, Spain

  • CIPREC

    Buenos Aires, C1061AAS, Argentina

  • CIPREC

    Buenos Aires, C1119ACN, Argentina

  • CTC Hodonin s.r.o.

    Hodonín, 695 01, Czechia

  • Care Access - Brandon

    Brandon, Florida, 33510, United States

  • Care Access - Mauldin

    Mauldin, South Carolina, 29662, United States

  • Carient Heart & Vascular - Manassas

    Manassas, Virginia, 20109, United States

  • Centro de Investigaciones Clínicas Baigorria

    Granadero Baigorria, 2152, Argentina

  • Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk

    Bydgoszcz, 85-092, Poland

  • Changde First People's Hospital

    Changde, 415000, China

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708, United States

  • China-Japan Union Hospital

    Changchun, 130033, China

  • Clinoxus

    Prague, 140 00, Czechia

  • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

    Seville, 41003, Spain

  • Complejo Asistencial Universitario de León - Hospital de León

    León, 24071, Spain

  • Dallas Heart and Vascular Consultants, PA

    Duncanville, Texas, 75137, United States

  • Diahelp s.r.o

    Pardubice V, 530 02, Czechia

  • Dorado Medical Complex

    Dorado, 00646, Puerto Rico

  • EAP Osona Sud - Alt Congost S.L.P

    Centelles, 08540, Spain

  • EAP Sardenya

    Barcelona, 08025, Spain

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814, United States

  • Eastside Research Associates

    Redmond, Washington, 98052, United States

  • Elite Clinical Studies, LLC

    Phoenix, Arizona, 85018, United States

  • Excel Clinical Research, LLC

    Las Vegas, Nevada, 89109, United States

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434, United States

  • Familienmedizinisches Zentrum Radowsky

    Leipzig, 04179, Germany

  • Fukuwa Clinic

    Chūōku, 104-0031, Japan

  • FutureMeds GmbH

    Berlin, 10629, Germany

  • G. Gennimatas General Hospital of Thessaloniki

    Thessaloniki, 546 35, Greece

  • G.B. Pant Institute of Postgraduate Medical Education & Research

    New Delhi, 110002, India

  • General Hospital of Athens "G. Gennimatas"

    Athens, 11527, Greece

  • Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien

    Dresden, 01277, Germany

  • Health Research of Hampton Roads, Inc.

    Newport News, Virginia, 23606, United States

  • Hospital Quiron Infanta Luisa

    Seville, 41010, Spain

  • Hospital San Rafael - La Coruña

    A Coruña, 15006, Spain

  • INECO Neurociencias Oroño

    Rosario, 2000, Argentina

  • IRMED

    Piotrkow Trybunalski, 97-300, Poland

  • Instituto Médico Especializado (IME)

    Buenos Aires, 1405, Argentina

  • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica

    Rosario, 2000, Argentina

  • Instituto de Investigaciones Clínicas Córdoba

    Córdoba, 5000, Argentina

  • Jinan Central Hospital

    Jinan, 250013, China

  • Life Care Hospital and Research Centre

    Bangalore, 560092, India

  • Lishui Central Hospital

    Lishui, China

  • Lucida Clinical Trials

    New Bedford, Massachusetts, 02740, United States

  • MUDr. Sarka Drinkova

    Ledeč nad Sázavou, 584 01, Czechia

  • Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic

    Yamato-shi, 242-0004, Japan

  • Medizentrum Essen Borbeck

    Essen, 45355, Germany

  • Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

    Matsuyama, 7900034, Japan

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, 85-231, Poland

  • NZOZ Regionalna Poradnia Diabetologiczna

    Wroclaw, 50-127, Poland

  • National Clinical Research, Inc

    Richmond, Virginia, 23294, United States

  • North Hills Family Medicine/North Hills Medical Research

    North Richland Hills, Texas, 76180, United States

  • Northeast Research Institute - Downtown Office

    Jacksonville, Florida, 32204, United States

  • Ordinace Rihackovi, s.r.o.

    Brno, 641 00, Czechia

  • Palm Research Center Sunset

    Las Vegas, Nevada, 89148, United States

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, 56403, Greece

  • Peace River Cardiovascular Center

    Port Charlotte, Florida, 33952, United States

  • Praglandia s.r.o

    Prague, 150 00, Czechia

  • PriMED Clinical Research

    Dayton, Ohio, 45429, United States

  • Private Practice - Dr. Robert Witek

    Tarnów, 33-100, Poland

  • Puerto Rico Medical Research

    Ponce, 00717, Puerto Rico

  • RED-Institut GmbH

    Oldenburg, 23758, Germany

  • Remington-Davis, Inc

    Columbus, Ohio, 43215, United States

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609, United States

  • Ruijin Hospital Shanghai Jiaotong University School of Medicine

    Shanghai, 200001, China

  • Santa Maria de la Salud Centro Medico

    San Isidro, 1642, Argentina

  • Shaanxi provincial people's hospital

    Xi'an, 710068, China

  • Sichuan Provincial People's Hospital

    Chengdu, 610072, China

  • Siping Central People's Hospital

    Siping, 136000, China

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303, United States

  • Takai Internal Medicine Clinic

    Kamakura-shi, 247-0056, Japan

  • Texas Institute of Cardiology, PA

    McKinney, Texas, 75071, United States

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471003, China

  • The Second Affiliated Hospital of Chongqing Medical University - Yuzhong Campus

    Chongqing, 400010, China

  • Tokyo-Eki Center-building Clinic

    Chūōku, 103-0027, Japan

  • Top Moravia Health

    Brno, 61500, Czechia

  • Universitaetsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • University Hospital of Ioannina

    Ioannina, 45500, Greece

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Bialystok, 15-276, Poland

  • Valley Clinical Trials, Inc.

    Covina, California, 91723, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu

    Przemyśl, 37-700, Poland

  • Wuxi People's Hospital

    Wuxi, 214023, China

  • Zentrum fur klinische Forschung - Köln

    Cologne, 51069, Germany

  • Zentrum für klinische Studien Bad Homburg

    Bad Homburg, 61348, Germany

Conditions

Explore the condition pages connected to this study.