New pill shows promise for kids with rare, Hard-to-Treat cancers
NCT ID NCT03899792
First seen Jan 11, 2026 · Last updated May 17, 2026 · Updated 17 times
Summary
This study tests an oral drug called LOXO 292 in children and teens with advanced solid or brain tumors that have a specific genetic change (RET alteration). The goal is to see if the drug can shrink tumors or stop them from growing. About 36 participants will receive the drug, and researchers will monitor side effects and how well the drug works.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Childrens Hospital of Los Angeles
Los Angeles, California, 90027, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3039, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Lombardy, 20133, Italy
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Gustave Roussy
Villejuif, 94805, France
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Hiroshima University Hospital
Hiroshima, 734-8551, Japan
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Hokkaido University Hospital
Sapporo, Hokkaido, 060-8648, Japan
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Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], 8035, Spain
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Kyoto University Hospital
Kyoto, 606-8507, Japan
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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National Cancer Center Hospital
Chuo-ku, Tokyo, 104-0045, Japan
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Nemours Children's Health
Orlando, Florida, 32827, United States
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Rigshospitalet
Copenhagen, 2200, Denmark
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Royal Children's Hospital
Melbourne, Victoria, 3052, Australia
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Seattle Children's Hospital Research Foundation
Seattle, Washington, 98105, United States
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Seoul National University Hospital
Seoul, Korea, 03080, South Korea
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Texas Childrens Hospital
Houston, Texas, 77025, United States
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The Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
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The Children's Hospital for Cancer and Blood Disorders
Aurora, Colorado, 80045, United States
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The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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University College Hospital - London
London, Greater London, NW1 2BU, United Kingdom
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University of Minnesota Hospital
Minneapolis, Minnesota, 55455, United States
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University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75390-9063, United States
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Universitätsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69115, Germany
Conditions
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