New hope for kids with Arthritis-Linked eye disease?

NCT ID NCT04088409

First seen Apr 28, 2026 · Last updated Apr 28, 2026

Summary

This study tests an oral drug called baricitinib in children aged 2 to 18 with active uveitis linked to juvenile idiopathic arthritis or a related antibody-positive condition. The goal is to see if the drug safely reduces eye inflammation. About 30 participants will receive baricitinib or an active comparator, with response measured by a standard eye inflammation scale.

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Contacts and locations

Locations

  • Alder Hey Children's Hospital

    Liverpool, England, L14 5AB, United Kingdom

  • Asklepios Klinik Sankt Augustin

    Sankt Augustin, North Rhine-Westphalia, 53757, Germany

  • Azienda Ospedaliero Universitaria Meyer

    Florence, 50100, Italy

  • Bristol Royal Hospital for Children

    Bristol, Bristol, City of, BS2 8BJ, United Kingdom

  • Cambridge Clinical Research Facility

    Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers, 86021, France

  • Charité Campus Virchow-Klinikum

    Berlin, 13353, Germany

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

    Milan, Lombardy, 20122, Italy

  • Great Ormond Street Hospital For Children NHS Foundation Trust

    London, WC1N 3JH, United Kingdom

  • HELIOS Klinikum Berlin-Buch

    Berlin, 13125, Germany

  • Hospital Infantil Universitario Niño Jesús

    Madrid, Madrid, Comunidad de, 28009, Spain

  • Hospital Sant Joan de Déu

    Esplugues de Llobregat, Barcelona, 08950, Spain

  • Hospital Universitario La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario La Paz

    Madrid, Madrid, Comunidad de, 28046, Spain

  • Hôpital Universitaire Necker Enfants Malades

    Paris, 75015, France

  • Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre

    Le Kremlin-Bicêtre, 94270, France

  • Praxis Kinder- und Jugendrheumatologie Dr. Ivan Foeldvari

    Hamburg, 22081, Germany

  • Royal Victoria Infirmary

    Newcastle upon Tyne, England, NE1 4LP, United Kingdom

  • Sheffield Children's Hospital

    Sheffield, S10 2TH, United Kingdom

  • University Hospital Southampton NHS Foundation Trust

    Southampton, Hampshire, SO16 0YD, United Kingdom

Conditions

Explore the condition pages connected to this study.