New hope for kids with eye inflammation: baricitinib trial shows promise

NCT ID NCT04088409

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether baricitinib, an oral drug, is safe and effective for children aged 2 to 18 with active uveitis (eye inflammation) linked to juvenile arthritis or a related condition. Participants had not responded well to standard treatments. The main goal is to reduce eye inflammation, with results expected to show if baricitinib can help control the disease.

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Conditions

The condition(s) this trial relates to.

uveitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UVEITIS

Contacts and locations

Locations

Alder Hey Children's Hospital

Liverpool, England, L14 5AB, United Kingdom
Asklepios Klinik Sankt Augustin

Sankt Augustin, North Rhine-Westphalia, 53757, Germany
Azienda Ospedaliero Universitaria Meyer

Florence, 50100, Italy
Bristol Royal Hospital for Children

Bristol, Bristol, City of, BS2 8BJ, United Kingdom
Cambridge Clinical Research Facility

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Centre Hospitalier Universitaire de Poitiers

Poitiers, 86021, France
Charité Campus Virchow-Klinikum

Berlin, 13353, Germany
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Lombardy, 20122, Italy
Great Ormond Street Hospital For Children NHS Foundation Trust

London, WC1N 3JH, United Kingdom
HELIOS Klinikum Berlin-Buch

Berlin, 13125, Germany
Hospital Infantil Universitario Niño Jesús

Madrid, Madrid, Comunidad de, 28009, Spain
Hospital Sant Joan de Déu

Esplugues de Llobregat, Barcelona, 08950, Spain
Hospital Universitario La Fe de Valencia

Valencia, 46026, Spain
Hospital Universitario La Paz

Madrid, Madrid, Comunidad de, 28046, Spain
Hôpital Universitaire Necker Enfants Malades

Paris, 75015, France
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre

Le Kremlin-Bicêtre, 94270, France
Praxis Kinder- und Jugendrheumatologie Dr. Ivan Foeldvari

Hamburg, 22081, Germany
Royal Victoria Infirmary

Newcastle upon Tyne, England, NE1 4LP, United Kingdom
Sheffield Children's Hospital

Sheffield, S10 2TH, United Kingdom
University Hospital Southampton NHS Foundation Trust

Southampton, Hampshire, SO16 0YD, United Kingdom

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