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Hope for Tough-to-Treat bone cancer: new combo trial launches

NCT ID NCT05440786

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding the drug abemaciclib to standard chemotherapy can help people with Ewing's sarcoma whose cancer has returned or not responded to treatment. About 46 children and young adults will take part. The goal is to see if the combination slows tumor growth better than chemotherapy alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Ewing sarcoma Ewing sarcoma/peripheral primitive neuroectodermal tumor metastatic neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASM METASTASIS SARCOMA, EWING

Contacts and locations

Locations

  • Centre Leon Berard

    Lyon, Auvergne-Rhône-Alpes, 69373 CEDEX 08, France

  • Charité Campus Virchow-Klinikum

    Berlin, 13353, Germany

  • Fondazione Policlinico Universitario Agostino Gemelli

    Rome, Lazio, 00168, Italy

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28009, Spain

  • Hospital Infantil Universitario Niño Jesús

    Madrid, Madrid, Comunidad de, 28009, Spain

  • Hospital Sant Joan de Déu

    Esplugues de Llobregat, Barcelona [Barcelona], 08950, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario La Paz

    Madrid, Madrid, Comunidad de, 28046, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalunya [Cataluña], 08041, Spain

  • Hyogo Prefectural Kobe Children's Hospital

    Kobe, Hyōgo, 650-0047, Japan

  • IRCCS Istituto Ortopedico Rizzoli

    Bologna, 40136, Italy

  • Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

    Bordeaux, Aquitaine, 33076, France

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Lifespan Cancer Institute

    Providence, Rhode Island, 02906, United States

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045, Japan

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria, 3000, Australia

  • Phoenix Children's Hospital

    Phoenix, Arizona, 85016, United States

  • Riley Hospital for Children at Indiana University Health

    Indianapolis, Indiana, 46202, United States

  • Royal Children's Hospital

    Melbourne, Victoria, 3052, Australia

  • The Children's Hospital at Westmead

    Westmead, New South Wales, 2145, Australia

  • The Regents of the University of California - Los Angeles (UCLA Pediatrics)

    Los Angeles, California, 90095-1752, United States

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • Universitätsklinikum Essen

    Essen, North Rhine-Westphalia, 45122, Germany

  • Washington University

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.