Could a diabetes drug shield kidneys in obesity? new trial explores tirzepatide's potential

NCT ID NCT05536804

First seen Oct 31, 2025 · Last updated Jun 13, 2026 · Updated 31 times

Summary

This study looks at whether tirzepatide, a medication already used for diabetes and weight loss, can help slow or improve chronic kidney disease in people with obesity. About 140 participants will take the drug and have MRI scans to measure kidney fat and blood flow over 56 weeks. The goal is to see if reducing kidney fat can protect kidney function, even in those without diabetes.

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Contacts and locations

Locations

  • Aarhus Universitetshospital, Skejby

    Aarhus, 8200, Denmark

  • American Health Network of Indiana, LLC - Avon

    Avon, Indiana, 46123, United States

  • American Health Network of Indiana, LLC - Greenfield

    Greenfield, Indiana, 46140, United States

  • American Health Network of Indiana, LLC - Muncie

    Muncie, Indiana, 47304, United States

  • Amsterdam UMC, locatie VUmc

    Amsterdam, 1081 HV, Netherlands

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098, United States

  • Caimed Investigacion En Salud S.A. de C.V.

    Mexico City, 06760, Mexico

  • Centre intégré universitaire de santé et de services sociaux de l'Estrie Centre Hospitalier Universitaire -T

    Sherbrooke, J1H 5N4, Canada

  • Centro de Investigación y Gastroenterología

    Cuauhtémoc, 06700, Mexico

  • Fadia El Boreky Medicine

    Waterloo, N2J 1C4, Canada

  • Grupo Medico Camino Sc

    Mexico City, 03310, Mexico

  • Health Pharma Professional Research S.A. de C.V:

    Mexico City, 03100, Mexico

  • Indiana University Health University Hospital

    Indianapolis, Indiana, 46202, United States

  • Instituto Nacional de Cardiologia Ignacio Chavez

    México, 14080, Mexico

  • Investigación Nefrológica

    Cuernavaca, 62448, Mexico

  • Kidney Associates of Colorado

    Denver, Colorado, 80210, United States

  • Klinik Hietzing

    Vienna, 1130, Austria

  • Klinik Landstraße

    Vienna, 1030, Austria

  • LMC Clinical Research Inc. (Barrie)

    Barrie, L4N 7L3, Canada

  • LMC Clinical Research Inc. (Thornhill)

    Concord, L4K 4M2, Canada

  • Providence Medical Research Center - Spokane

    Spokane, Washington, 99204, United States

  • Toronto General Hospital

    Toronto, M5G 2C4, Canada

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Zentrum für klinische Studien Dr Hanusch Gmbh

    Vienna, 1060, Austria

  • Ziekenhuisgroep Twente, locatie Almelo

    Almelo, 7609 PP, Netherlands

Conditions

Explore the condition pages connected to this study.