OSTEOARTHRITIS OF THE KNEE

This study tests whether a lab-grown sheet of human cartilage cells (CLS2901C) can improve knee function and reduce pain in people with knee osteoarthritis. About 96 adults aged 20–79 who need knee realignment surgery will receive either the cell sheet plus surgery or surgery alo…

This study is testing whether a treatment made from a patient's own bone marrow cells (StroMed) combined with platelet-rich plasma can safely reduce pain and inflammation from knee osteoarthritis. The trial plans to enroll 4,000 people with moderate to severe knee arthritis. Rese…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study compares two exercise programs for people with knee osteoarthritis: supervised cycling on a stationary bike and a land-based therapeutic exercise program with strengthening and balance training. The goal is to see which approach better reduces pain sensitivity during a…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This study tests whether a compressive cryotherapy device (Game Ready®) can reduce the need for opioid painkillers after total knee replacement surgery. About 74 adults aged 60-80 will be randomly assigned to use either the device or traditional ice packs four times daily for a w…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for stron…

This study compares two types of nerve blocks to control pain after total knee replacement. 78 adults will receive one of two combinations of ultrasound-guided injections near the knee. The goal is to see which approach reduces pain and the need for opioid painkillers in the firs…

This study is testing whether giving extra doses of tranexamic acid (TXA) after hip or knee replacement surgery can reduce bleeding, pain, and help people move around sooner. TXA is a drug already used during surgery to prevent blood loss. The trial will compare the standard sing…

This study is testing whether using a special sensor device during knee replacement surgery leads to better results for patients. The device helps the surgeon make precise bone cuts. Researchers will follow 40 people for up to 2 years after surgery, measuring pain, function, and …

This study tests a new nerve block called BiFeS against the standard iPACK block for pain after knee replacement surgery. 88 adults having a knee replacement will be randomly assigned to receive one of the two blocks. The goal is to see which provides better pain relief and helps…

This study tests whether a short course of the steroid methylprednisolone, taken as pills after knee replacement surgery, can reduce pain, opioid use, and nausea. About 420 adults having knee replacement for osteoarthritis will receive either the steroid or a placebo. The goal is…

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

This early-stage study tests a single injection of AVD275, a new form of the pain reliever celecoxib, in 15 adults with knee osteoarthritis. The goal is to check safety and how the drug spreads in the body. Participants will be monitored for 24 weeks after the shot.

This study tests whether taking creatine supplements for 12 weeks helps adults aged 65 and older regain muscle mass, strength, and physical function after total knee replacement surgery. Participants will take creatine or a placebo daily alongside standard rehabilitation. The goa…

This study looks at whether keeping or removing the posterior cruciate ligament during robotic knee replacement helps patients feel more natural after surgery. About 300 adults having their first robotic knee replacement will be randomly assigned to one of the two methods. The ma…

This study tests whether a structured preparation program before hip or knee replacement surgery can help people recover faster. The program includes personalized exercise, nutritional advice, stress and pain support, and medication review. Researchers will compare recovery in 18…

This study tests two different methods of a nerve block (iPACK) to manage pain after total knee replacement. The goal is to find which approach provides better pain relief and reduces the need for strong painkillers. 120 adults having knee replacement will be randomly assigned to…

This study compares a special cold-and-compression device to regular ice packs for managing pain after total knee replacement. About 138 adults having knee surgery will be randomly assigned to one of the two treatments. The main goal is to see if the device reduces pain more than…

This study tests whether teaching patients about nutrition and following a specific fasting plan before knee replacement surgery can help reduce thirst, nausea, and vomiting afterward. About 72 adults having knee replacement will be split into two groups: one gets the special edu…

This study tests whether adding a fall prevention program to standard physical therapy can reduce falls and improve balance in older adults who have had a total knee replacement. About 90 women aged 60 and older will be followed for 24 weeks. The program includes guidance on avoi…

This study tests three different doses of a long-acting numbing medicine (liposomal bupivacaine) injected into a nerve block in the thigh to control pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to receive one of the dos…

This pilot study tests a new pain-numbing injection called IPSA, given by the surgeon directly into the back and inner side of the knee during total knee replacement. 60 adults undergoing knee replacement will be randomly assigned to receive either the new IPSA block plus standar…

This study tests whether a special heat wrap can reduce knee pain in people with moderate osteoarthritis. About 80 adults aged 19 to 69 will wear the wrap for 8 hours a day over 7 days. Researchers will measure pain changes after 3 days using a simple pain scale.

This phase 2 trial is testing whether daily doses of THC, CBD, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 participants will take one of the study drugs or a placebo for 16 weeks, with regular pain assessments, blood tests, and brain…

This pilot study aims to see if a new method can safely measure how tired patients get during a special type of exercise after total knee replacement. Twenty adults recovering from knee surgery will try cycling while blood flow to their legs is partially restricted. The results w…

This study aims to create a model that predicts how long patients will need inpatient rehabilitation after hip or knee replacement for osteoarthritis. Researchers will collect data from 400 patients to validate the model. The goal is to personalize care and improve quality of lif…

This study looks at whether having total knee replacement surgery as an outpatient (going home the same day) leads to better recovery compared to staying in the hospital. Researchers will review medical records of 440 patients who had knee replacement between 2020 and 2023 at a F…

This study looks at whether the routine one-year follow-up visit and X-ray after total hip or knee replacement is really needed. Researchers will compare patients who have a check-up only when they have concerns versus those who follow the standard yearly schedule. The goal is to…