OSTEOARTHRITIS OF THE KNEE

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This Phase 3 trial tested a single injection of TG-C, a cell-based treatment, in 531 people with moderate knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo injection. Participants were followed for 24 months to check safe…

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-…

This completed trial tested a new device called the NEUROCUPLE™ patch, which uses nanotechnology to reduce pain after knee replacement surgery. 156 adults were randomly assigned to receive either the active patch or a placebo patch for 30 days. The goal was to see if the patch co…

This study tested whether using virtual reality before or during total knee replacement surgery could help lower anxiety and improve recovery quality. 120 adults who had the surgery participated. The results showed that VR may be a simple, drug-free way to help patients feel calm…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested whether giving the sedative drug dexmedetomidine during knee replacement surgery could lengthen the time before patients need additional painkillers. 94 adults having elective knee replacement under regional anesthesia received either the drug or a placebo. The …

This study compared a single injection of sterile amniotic fluid to the standard steroid shot for knee osteoarthritis. 60 adults with moderate knee arthritis who had not gotten relief from other treatments took part. The main goal was to see if the amniotic fluid could reduce the…

This study tested whether adding a genicular nerve block to a standard femoral nerve block improves pain control after total knee replacement. Eighty adults having knee surgery were split into two groups: one got the standard block, the other got both blocks. Researchers measured…

This Phase 3 trial tested an experimental drug called RTX-GRT7039, given as an injection into the knee joint, to see if it reduces pain from osteoarthritis. 469 adults with knee osteoarthritis who did not get enough relief from standard treatments took part. The study compared th…

This Phase 3 trial tested whether a single injection of RTX-GRT7039 into the knee can reduce pain in adults with knee osteoarthritis who haven't gotten enough relief from standard treatments. 466 participants received either the drug or a placebo injection. The study measured pai…

This phase 3 trial tested the safety of an experimental drug called RTX-GRT7039, given as a knee injection to 714 adults with moderate to severe osteoarthritis pain that wasn't helped by standard treatments. The study focused on side effects and did not measure how well the drug …

This study tested whether using a cold and compression brace for six weeks after knee replacement surgery helps reduce pain and the need for painkillers. 208 patients who had a total or partial knee replacement were asked to use the brace five times a day for up to 20 minutes. Re…

This study looked at 60 adults who had knee replacement surgery to see which of two nerve block combinations worked better for pain. One group got a biceps femoris short head block plus an adductor canal block, and the other got an IPACK block plus an adductor canal block. Resear…

This study tested three simple distraction methods—virtual reality headset, a squishy squeeze toy, and poetry reading—to see if they could help control pain after total knee replacement surgery. 140 adults were split into four groups, with three trying one of the distractions and…

This study looked at two different massage methods—instrument-assisted soft tissue mobilization and cross fiber massage—to see which works better for pain and movement after total knee replacement. 50 adults aged 40-60 who had knee replacement surgery took part. The goal was to f…

This study tested whether using 10 mL or 20 mL of numbing medicine around the knee after replacement surgery could reduce the need for strong painkillers. 120 adults having knee replacement took part. The goal was to see if the smaller dose works just as well, with less medicatio…

This early-stage study tested a single injection of a new drug (SAR446959) into the knee joint of 32 adults aged 45-65 with knee osteoarthritis. The main goal was to check safety and how the drug moves in the body, not to prove it works. Participants were monitored for about 6 mo…

This study tested a drug called MT-5547 (fasinumab) in 626 Japanese adults with moderate to severe osteoarthritis pain in the knee or hip. Participants received either the drug or a placebo injection for 16 weeks. The goal was to see if the drug reduces pain and improves daily fu…

This study tested whether a telerehabilitation program—where patients do exercises at home with remote support from a physiotherapist via video calls, phone, and texts—can reduce pain and improve knee function in people with knee osteoarthritis. 118 patients aged 50 and older wit…

This study tested whether ear acupoint therapy (a type of acupuncture on the ear) can help people recover faster after total knee replacement surgery. 116 patients aged 50-80 participated. The therapy aimed to reduce pain, swelling, anxiety, and improve knee movement and scar hea…

This study tested whether the drug duloxetine, typically used for depression, can help reduce pain and the need for opioids after knee replacement surgery. Researchers enrolled 241 adults undergoing knee replacement and gave them either duloxetine or a placebo. The goal was to se…

This phase 2 trial tested an experimental implant called ATX101 that slowly releases the numbing drug bupivacaine into the knee after total knee replacement surgery. The study involved 226 adults and compared ATX101 to a saline placebo and standard bupivacaine injections. The goa…

This study tested an 8-week mindfulness program (MBSR) in 40 adults with painful hip or knee osteoarthritis. Participants learned to focus on the present moment to better manage chronic pain. The goal was to see if mindfulness could reduce pain and improve daily function compared…

This study tested a single injection of polyacrylamide hydrogel (Arthrosamid®) into the knee joint of 387 people with knee osteoarthritis. Researchers measured pain and physical function over 12 months. The goal was to see if the gel could reduce pain and improve everyday movemen…

This study looked at 40 people who had knee replacement surgery to see if the type of implant affects recovery. One group got a cruciate-retaining implant, the other a posterior-stabilized implant. Researchers measured pain, function, fear of movement, quality of life, and how mu…

This study looked at knee tissue that was removed during total knee replacement surgery in 29 patients. The goal was to learn more about how knee diseases and injuries affect bone and tissue structure, and to test new ideas for future treatments like custom implants or 3D-printed…

This pilot study tested whether wearable sensors (Syde devices) can reliably track knee osteoarthritis symptoms at home over two months. 43 participants wore the sensors on their ankles and wrists to record movement data, which was compared with standard clinic tests. The goal wa…

This study tested a surgical navigation system called NextAR TKA that helps surgeons balance soft tissues during knee replacement. Forty adults scheduled for knee replacement with a specific implant were enrolled. The goal was to see if the system improves patient-reported outcom…

This completed study used Danish national health records to compare infection rates after total knee replacement in obese (BMI ≥30) versus non-obese patients. Researchers analyzed data from over 100,000 adults who had knee replacement for osteoarthritis between 2011 and 2021. The…

This study compared how well an AI chatbot (ChatGPT) answered common questions from people with knee or hip osteoarthritis versus answers from real doctors. 286 patients rated the responses for preference, length, and difficulty. The goal was to see if AI could provide acceptable…

This study looked at 250 adults having total knee replacement to compare two surgical approaches: resurfacing the kneecap (patella) with a plastic implant versus leaving the natural cartilage in place. The goal was to see which method leads to better knee function and comfort one…

This study looked at 33 patients who had total knee replacement surgery to see if their recovery scores at 6 hours were similar to those at 24 hours. The goal was to understand if patients could be safely discharged earlier. Researchers used a standard scoring system to measure r…