OSTEOARTHRITIS OF THE KNEE

This study compares two versions of the Triathlon total knee prosthesis—one fixed with bone cement and one without—in 60 people with knee osteoarthritis. Researchers will use special X-ray techniques to see how well each implant stays in place over time, and also track patients' …

This study follows 148 people with knee osteoarthritis who received the ANTHEM total knee replacement system. Researchers will check how well the implant holds up over 10 years by measuring survival rates and patient-reported knee function. The goal is to confirm the device is as…

This Phase 3 trial tests a single injection of TG-C, a cell-based treatment, in 535 people with moderate knee osteoarthritis. The goal is to see if it reduces pain and improves knee function compared to a placebo injection. Participants are followed for two years to check safety …

This study tests a new uncemented knee replacement made with a porous metal called Tritanium, which may help bone grow into the implant for stronger fixation. It compares this to the standard cemented knee replacement in 72 patients with osteoarthritis. The goal is to see if the …

This study compares two types of nerve blocks—genicular nerve block and adductor canal block—for pain relief after total knee replacement. It involves 42 adults over 65 undergoing elective knee surgery. The goal is to see which block provides better pain control and helps patient…

This study compares two knee replacement systems, Persona and NexGen, in 332 people with knee osteoarthritis. Participants receive one of the two implants during surgery. Researchers track pain, function, and quality of life for up to two years to see if one system leads to bette…

This study compares two types of pain-relief pumps placed inside the knee joint after total knee replacement. 65 adults having outpatient knee surgery will be randomly assigned to receive either standard pain management or one of two pump brands. The goal is to see which approach…

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…

This study looks at whether a 6-day course of oral steroids after orthopedic surgery can help reduce pain, nausea, and improve movement. About 500 adults having common surgeries like joint replacement or fracture repair will be randomly assigned to receive either standard care or…

This study tests whether cutting a small nerve in the knee during a total knee replacement can reduce long-term pain. 178 adults having their first knee replacement will be randomly assigned to get either the standard surgery or the surgery plus the nerve cut. Researchers will tr…

This study tested whether two types of gentle brain stimulation (tDCS and TUS) can reduce pain and improve daily function in people with chronic knee osteoarthritis. 64 adults with persistent knee pain received either real or sham stimulation. Researchers measured changes in pain…

This study was designed to test whether PG201, a botanical drug, could reduce pain and improve function in people with knee osteoarthritis. It planned to enroll Korean adults aged 40 to 75 and compare two doses of PG201 against a placebo over 8 weeks. However, the trial was withd…

This study follows 200 people who received a smart knee implant (Persona IQ) that tracks movement after total knee replacement. The goal is to see if data from the implant and a phone app can help doctors understand recovery and spot problems early. Participants use a smartphone …

This study aimed to compare knee movement in people who had one of two different total knee replacements. Researchers planned to measure how the knee bends and shifts during activities like stepping up and deep knee bends. The study was withdrawn before any participants were enro…

This study looks at whether using a 3D patient-specific alignment during knee replacement surgery leads to better walking, less pain, and stronger muscles. Researchers will measure movement, pain, and strength in 45 adults who had surgery two years ago. The goal is to understand …