COVID19

This early-stage study tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The goal was to see if the vaccine is safe and to measure the immune response it produces. Researchers compared two different formulations to find the best balance…

This study tested whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 to those with severe COVID-19 is safe and helpful. 350 adults with severe or critical COVID-19 received a transfusion of this plasma. Researchers tracked side effects and de…

This study tested two drugs, ruxolitinib and fostamatinib, in 185 hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe, such as needing a ventilator or dying. Patients took the drug for 14 …

This study looked at whether giving a blood thinner (heparin) as a mist to COVID-19 patients on breathing machines could help them recover faster. Researchers combined results from several small trials in Australia, Ireland, the US, and the UK. The goal was to see if the treatmen…

This study tested whether certain drugs could help hospitalized COVID-19 patients with severe breathing problems. About 473 participants received either a study drug plus standard care or a placebo plus standard care. The goal was to see if the drugs improved safety and recovery.

This study tested a blood-filtering procedure called plasma exchange in 21 adults with severe COVID-19 and breathing problems. The goal was to remove harmful inflammatory substances from the blood to improve lung function and reduce the need for a breathing tube. Patients receive…

This study tested the drug remdesivir in 87 hospitalized COVID-19 patients who had acute respiratory failure (severe lung problems). Participants received either remdesivir plus standard care or a placebo plus standard care. The main goal was to see how well patients recovered by…

This study aimed to collect plasma from people who recovered from COVID-19 and give it to critically ill patients to help them fight the infection. The study enrolled 117 participants but faced major challenges because West Virginia lacked the equipment and licenses needed to col…

This study tested a drug called aviptadil in 471 hospitalized COVID-19 patients with severe breathing problems. Researchers wanted to see if adding aviptadil to standard care helped patients recover better than a placebo. The main goal was to check patients' recovery status 90 da…

This study tested an herbal supplement called AntiCov-220 in 82 people with high-risk conditions like HIV, hepatitis, or cancer. The goal was to see if it could safely prevent or treat COVID-19 by boosting the immune system and fighting the virus. Results suggest it may help redu…

This study tested a new way of using breathing machines for COVID-19 patients with severe lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. About 220 adults on ventil…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness and long COVID in 1,323 adults with early COVID-19. Participants were overweight or obese and not hospitalized. The key finding was that metformin reduced the risk of …

This early study tested whether certain mouthwashes could reduce the amount of SARS-CoV-2 virus that infected people breathe or cough out. 34 adults with confirmed COVID-19 provided breath and saliva samples before and after using a mouthwash or water. The goal was to see if mout…

This study looked at whether giving hospitalized COVID-19 patients two doses of plasma from people who had recovered from COVID-19, on top of standard care, helps them recover faster. 55 adults with pneumonia or low oxygen levels took part. The main goal was to see if this treatm…

This study tested whether using box fans with special filters and improving home ventilation can lower the chance of COVID-19 spreading from one sick person to others living in the same house. Over 200 people from households with at least 4 members took part. Researchers measured…

This study tested two practical methods to increase COVID-19 vaccination among over 65,000 patients at Utah community health centers. One group received text message reminders to get vaccinated, while another group got texts plus a personal navigator to help with logistics like s…

This study looked at whether testing people for COVID-19 just before a large indoor concert could keep the event from causing new infections. Over 6,600 healthy adults aged 18-45 either attended the concert after a negative test or stayed home. The goal was to see if the concert …

This large study tested whether common medications already used for other conditions could help reduce symptoms of mild to moderate COVID-19 in adults aged 30 and older. Over 10,000 people participated from home, taking either a study drug or a placebo and reporting their symptom…

This study tested whether common medications, originally made for other illnesses, could help adults aged 30 and older recover faster from mild to moderate COVID-19 without needing hospital care. Over 3,200 participants took either a study drug or a placebo and reported their sym…

This study tested a 21-herb formula called modified Qing Fei Pai Du Tang (mQFPD) in 60 adults with mild-to-moderate COVID-19 who were recovering at home. The goal was to see if the herbal treatment is safe and practical to use. Participants received either the herbal formula or a…

This study tested a 6-week program called Heart Up! that uses text messages and social support to help adults with heart disease become more physically active and feel less hopeless. About 224 patients who had a heart attack or related procedure took part. The program aimed to im…

This study looked at whether playing motion-controlled video games in virtual reality can help people with long COVID feel less pain and fatigue, improve their mood, and boost their quality of life. About 79 adults who had COVID-19 more than 90 days ago and still had symptoms for…

This study tested whether adding functional electrical stimulation (FES) to cycling exercises helps people who had severe COVID-19 recover faster. 22 patients who needed a breathing machine were split into two groups: one did cycling with FES, the other without. The goal was to s…

This early study tested whether a 30-week home walking program is safe for cancer patients who had been hospitalized for COVID-19. Only 3 people took part, so the results are very limited. The goal was to see if the exercise caused few or mild side effects.

This study tested three remotely delivered programs to help adults with depression, anxiety, and substance use related to COVID-19 stress. 113 participants were randomly assigned to an 8-week mindfulness program, an online cognitive behavioral therapy program, or remote monitorin…

This study looked at the best ways to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find what messages and strategies work best to k…

This study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or lupus). Researchers measured stress, depression, and anxiety levels over 6 months. The goal was to unde…

This study looked at how the COVID-19 pandemic affected online gambling habits in France and Sweden. Researchers analyzed data from 120,000 gamblers to see if lockdowns and stress changed how much people gambled. The goal was to understand risky behaviors and help public health o…

This study looked at how a mix of home and in-person exercise sessions affects the body in people with chronic lung diseases like COPD and sleep apnea, as well as those recovering from COVID-19. The goal was to see if this program helps with muscle loss and fatigue. 72 adults age…

This study followed 105 pregnant women diagnosed with COVID-19 to learn how their immune systems responded and whether that protection passed to their babies. Researchers measured antibodies in the mothers' blood and breast milk, as well as in umbilical cord blood at delivery. Th…

This study looked at whether strict COVID-19 rules in nursing homes (like banning visitors and confining residents to rooms) helped or hurt residents. Researchers tracked over 12,000 residents for one year to see if these measures changed death rates, both from COVID and other ca…

This study looked at the mental health of 701 healthcare workers (doctors, nurses, and aides) who cared for COVID-19 patients in intensive care units. Researchers measured rates of post-traumatic stress disorder (PTSD), anxiety, depression, and burnout using standard questionnair…

This study tested different drug combinations in people with COVID-19 to see if they helped patients recover faster and survive. Only 4 people took part. The main goal was to measure how long it took for patients to get better and to track deaths. The trial is now complete.

This completed study looked at how different treatments and natural supplements affect the immune system of people with COVID-19. The goal was to find ways to help patients recover faster and lower the death rate. The study included 150 patients who had symptoms, a positive test,…

This study measured immune responses after two doses of the Pfizer COVID-19 vaccine in 539 adults, including those with weakened immune systems (e.g., from organ transplant, HIV, or cancer treatment) and healthy individuals. Researchers analyzed blood and saliva samples to see ho…

This study looked at how the thymus gland, which produces immune cells called T cells, might influence COVID-19 severity. Researchers compared 85 hospitalized patients with and without COVID-19 to see if genetic differences in thymus function were linked to worse lung damage. The…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their ability to move and do daily activities changed over time. Researchers measured mobility, thinking skills, and frailty after discharge. The goal is to understand recovery patterns and help d…

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies from infection or vaccination. Researchers followed 152 adults and children with CF for two years, taking blood samples every six months. They aimed to understand how many had antibodies, how l…

This study used advanced total-body PET scans to compare lung function in 13 people who had COVID-19 with healthy individuals. The goal was to see how the virus affects the blood-air barrier in the lungs over time. Participants were scanned within 8 weeks of diagnosis and again 4…

This study followed 187 people who had COVID-19 to see how their antibody levels changed over 24 months. Researchers measured both general and neutralizing antibodies, and also looked at how disease severity and vaccination affected these levels. The goal was to better understand…

This study followed 610 adults who had heart surgery to see how often they develop postoperative delirium—a sudden state of confusion that can come and go. Researchers collected information on known risk factors like age, high blood pressure, and diabetes, and tracked outcomes su…

This study looked at 21 COVID-19 patients who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used advanced MRI scans to detect brain changes. The goal was to better understand how the virus can affect the brain, not to test a treatment.

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom testing. The goal was to see which approach reduced COVID-…

This study followed 200 adults who had COVID-19 to see how the virus affects their heart and mental health over time. Participants wore a health tracker to monitor heart problems like irregular beats and heart failure, and completed surveys about anxiety, depression, and substanc…

This study looked at 57 adults with mild or no COVID-19 symptoms to understand how their immune system responds to the virus. Researchers measured immune markers and how quickly the virus cleared from the body. The goal was to learn why some people fight off the infection easily,…

This study followed 355 adults in Suffolk and North Essex who had Long COVID (symptoms lasting after a COVID-19 infection). The goal was to describe their symptoms and rehabilitation needs up to 36 months after getting sick. Researchers focused on how the condition affected daily…

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers tracked their thinking, movement, and emotional health as they moved from hospital to home. The goal was to better understand the challenges these patients face durin…

This study aimed to develop a breath test that could help diagnose or predict the course of liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants to detect unique chemical patterns. The goal was to see if a simple, non-invasive breat…

This study followed 1,366 people in Luxembourg who tested positive for COVID-19. Researchers tracked their symptoms and health for up to a year to understand why some people get very sick while others have mild illness. The goal was to find factors that predict severe disease, no…

This study tested whether adding a rapid tuberculosis (TB) test to standard care can reduce deaths in young children hospitalized with severe pneumonia. Over 2,500 children aged 2 to 59 months in six high-TB-burden countries took part. The test uses stool and nose samples to find…

This completed study looked at 543 people who survived severe COVID-19 lung injury (ARDS) to see if their social and economic background influenced how well they recovered physically and mentally. Researchers measured lung function, exercise ability, and psychological health six …

This study followed 829 adults who had COVID-19 to see how long their immune system remembered the virus. Researchers measured antibodies in blood samples taken during the hospital stay and for up to 12 months after. The goal was to understand how long natural immunity might last…

This study looked at whether weakness in the diaphragm, the main breathing muscle, causes ongoing shortness of breath and fatigue in people who had COVID-19 but were not hospitalized. Researchers measured breathing muscle strength and used ultrasound in 25 adults. The goal was to…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers used molecular tests to find active infections and blood tests to check for past infections and immunity. The goal was to understand infection rates, incl…

This study looked at why some people who were hospitalized for COVID-19 still feel tired and short of breath. Researchers measured breathing muscle strength in 50 survivors—half had been on a ventilator, half had only needed extra oxygen. The goal was to understand how severe COV…

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very ill pat…

This study measured COVID-19 antibodies in over 2,800 primary care health workers (like doctors, pharmacists, and dentists) and their household members in France. The goal was to understand how many had been exposed to the virus and how their immune systems responded. Results hel…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder, depression, and burnout using standard questionnaires. The goal was to understand how common t…

This completed study looked at 60 adults with severe breathing failure (ARDS), including from COVID-19, to understand why lying face-down (prone positioning) improves oxygen levels. Researchers used lung ultrasound to measure lung health before and after prone sessions. The goal …

This study tracked 11,000 COVID-19 patients to find out how often they developed dangerous blood clots in arteries or veins, and what factors increased that risk. Researchers looked at medical records to understand clot prevention, treatment patterns, and outcomes like death or b…

This study looked at how the COVID-19 pandemic changed the way people with multiple sclerosis (MS) reported and managed their relapses. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April–June 2020) with those who had a relapse during t…

This study looked at how a COVID-19 infection during pregnancy, along with related stress, might affect a baby's brain development. Researchers followed 62 mothers and their infants, using surveys to measure stress and mental health, and brain scans (EEG and MRI) to check the bab…

This study followed 214 people who tested positive for COVID-19. Participants received daily text messages asking about their symptoms, like fever, cough, and loss of taste. The goal was to learn how symptoms change throughout the day and over the course of the illness. This rese…

This study looked at eye problems in 23 COVID-19 patients in intensive care. Researchers checked for damage to the cornea, retina, and optic nerve to find issues early and prevent vision loss. The goal was to learn how common these injuries are and improve care.

This study followed 300 adults who had mild to moderate COVID-19 but were not hospitalized. Researchers called them monthly for a year to see how long symptoms lasted and how they affected daily life. The goal was to learn more about lingering symptoms after a mild infection.

This study looked at whether the COVID-19 vaccine triggers a strong immune response in people with multiple myeloma or Waldenstrom's macroglobulinemia, two types of blood cancer. About 146 adults took part, and researchers measured their antibody levels 28 days after the final va…

This study asked 714 breast cancer survivors about their experiences with the COVID-19 vaccine. Researchers wanted to understand if lymph node swelling—a common vaccine side effect—caused worry or raised the risk of lymphedema (arm swelling) in these patients. The study collected…

This study investigated whether COVID-19 infection makes people more likely to develop pulmonary embolism (PE), a serious blood clot in the lungs. Researchers reviewed CT scans and COVID-19 test results from 347 patients in Scotland. The goal was to confirm and measure this link …

This study followed over 1,000 people in the Dominican Republic to understand how COVID-19 spreads and how to control it. Researchers tracked symptoms, tested for antibodies, and asked about handwashing and vaccines. The goal was to learn more about the virus and find better ways…

This study looked at whether people with cystic fibrosis (CF) have different immune responses to COVID-19. Researchers tested blood samples from 113 CF patients in Europe over two years to check for antibodies from natural infection or vaccination. The goal was to understand why …

This study compared two methods to increase COVID-19 testing among patients at Utah community health centers: text message reminders alone versus text messages plus a patient navigator who helped with logistics. Over 44,000 English- or Spanish-speaking adults with a working cell …

This study tracked 6,000 adults who had COVID-19 symptoms to see how their health changed over 18 months. Participants filled out online surveys every 3 months. The goal was to learn about long-term problems like chronic fatigue or heart issues, not to test a treatment.

This study used a special type of MRI (called hyperpolarized 129Xe MRI) to look at lung structure and function in 42 adults who had recovered from mild, moderate, or severe COVID-19. The goal was to understand how the virus affects breathing over time. Participants were scanned a…

This study collected blood, urine, and kidney tissue samples from 90 adults hospitalized with COVID-19 who also had or were at risk for acute kidney injury. Researchers aimed to build a detailed database of these samples to better understand how COVID-19 affects the kidneys. The …

This study examined eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used advanced eye scans to look for problems caused by the virus, inflammation, or blood clots. The goal was to better understand what eye issues can occur after a serious COVID-19 …

This study tracked 219 adults with severe COVID-19 who needed a ventilator to breathe. Researchers wanted to find out how many also developed serious fungal infections, especially a lung infection called aspergillosis. They used standard tests to check for these infections in a c…

This study looked at 332 adults who had severe COVID-19 pneumonia and needed oxygen in the hospital. Researchers used CT scans and breathing tests to check for lasting lung damage three months after discharge. The goal was to understand how often and how severe these respiratory …