BREAST NEOPLASMS

This study tests whether a telerehabilitation program, done at home after breast cancer surgery, can prevent common complications like pain, swelling, and limited arm movement. Researchers will compare 155 women who receive the remote rehab to those who follow standard care. The …

This study provides ongoing access to the drug niraparib for people with ovarian or breast cancer who have already completed a prior niraparib study and are still benefiting from treatment. The main goal is to monitor long-term safety, including side effects and changes in overal…

This study compares a combination of two drugs (elacestrant and capecitabine) to capecitabine alone in people with advanced estrogen receptor-positive breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to one of the two t…

This phase 3 study tests a new drug, patritumab deruxtecan, against standard chemotherapy or another targeted drug (trastuzumab deruxtecan) in people with advanced or metastatic HR+/HER2- breast cancer that cannot be surgically removed. The goal is to see if the new drug helps pe…

This early-phase trial tests a new treatment for people with a type of stomach or esophageal cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells carrying a protein c…

This study tests whether adding a new drug (LY4064809) to standard hormone therapy and a CDK4/6 inhibitor can better control advanced breast cancer that has a specific genetic change (PIK3CA mutation). About 920 adults with HR+, HER2- breast cancer that has spread and has not bee…

This study is testing whether adding the drug dalpiciclib to standard hormone therapy can help keep early-stage HR+/HER2- breast cancer from returning. About 2000 women with stage II or III breast cancer will receive either a lower dose for 3 years or a higher dose for 2 years. R…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …

This study tests a new medicine called disitamab vedotin in people with advanced breast cancer that has spread and is hard to treat. Participants must have tumors with a protein called HER2 and have had prior treatment. Everyone receives the drug by IV every two weeks to see if i…

This study tests a new drug, LY4337713, that delivers radiation directly to cancer cells with a specific protein called FAP. It is for adults with advanced or spread cancers like pancreatic, breast, ovarian, or colorectal cancer. The main goals are to check safety, side effects, …

This study tests whether a daily pill (Z-endoxifen) plus a monthly shot (goserelin) can slow or stop estrogen-driven breast cancer growth in premenopausal women. About 87 participants will take the drugs for up to 24 weeks before surgery. The main goal is to see if the treatment …

This study tests a new drug called izalontamab brengitecan (BMS-986507) against standard chemotherapy in about 500 people with advanced triple-negative or ER-low breast cancer who cannot receive immunotherapy. The drug is designed to target and kill cancer cells while sparing hea…

This study tests whether tirzepatide, a weight-loss drug, can help clear tiny amounts of cancer DNA from the blood of patients with obesity or overweight who have had hormone-positive, HER2-negative, node-positive early breast cancer. Participants will receive tirzepatide plus st…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study is for people with high-risk early-stage triple-negative or hormone receptor-low positive/HER2-negative breast cancer. It tests whether adding a new drug (patritumab deruxtecan) to standard chemotherapy and immunotherapy before surgery can eliminate more cancer cells. …

This study tests a drug called patritumab deruxtecan in people with HER2-positive breast cancer that has spread or cannot be removed by surgery. The main goals are to check safety and see if the drug can shrink tumors. About 81 adults will take part in this early-phase trial.

This study tests a new way of giving chemotherapy called adaptive therapy for people with advanced breast cancer that has gotten worse after standard treatments. The goal is to see if adjusting the dose over time can help control the cancer longer and with fewer side effects. Abo…

This early-phase study tests an experimental pill, CID-078, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the best dose. About 220 participants will take the drug by mouth, and researchers wil…

This study tests whether adding a targeted therapy (Sac-TMT) to standard chemotherapy and immunotherapy before surgery helps more people with high-risk, early-stage triple-negative or hormone-receptor-low breast cancer achieve a complete response (no cancer left in breast or lymp…

This study follows about 3,250 people with a common type of early breast cancer that has a high chance of coming back. Participants take Kisqali plus hormone therapy as part of their normal care. Researchers will track how well the treatment prevents cancer from returning, any si…

This study tests a new combination of drugs for people with advanced breast or stomach cancers that have a protein called HER2. The experimental drug disitamab vedotin is designed to stick to cancer cells and kill them, and it is combined with the approved drug tucatinib. The goa…

This study tests a new drug called BNT327 combined with chemotherapy for people with advanced triple-negative breast cancer that cannot be treated with standard immunotherapy. About 558 participants will be randomly assigned to receive either BNT327 plus chemo or a placebo plus c…

This study looks at whether a blood test (Signatera) can help doctors decide when to start a targeted cancer pill (CDK4/6 inhibitor) in people with intermediate-risk HR+ HER2- breast cancer. About 725 participants will be followed for up to 9 years. Those with a positive blood te…

This phase 3 trial tests whether a new drug (MK-2870), alone or with another drug (pembrolizumab), works better than standard treatments for people with a common type of advanced breast cancer (HR+/HER2-). About 1,200 participants whose cancer has worsened after hormone therapy w…

This study tests whether an augmented reality (AR) system can help surgeons remove all breast cancer during breast-conserving surgery. About 94 women with breast cancer will be randomly assigned to have surgery guided by AR or by the usual ultrasound skin marking. The main goal i…

This early-phase study is testing a new radioactive imaging agent called [68Ga]Ga-DWJ155 to see how well it shows up on PET scans in people with advanced breast cancer or advanced non-small cell lung cancer. The goal is to measure how the agent spreads in the body and whether it …

This study is testing two new imaging agents that light up breast cancer cells on PET scans. Researchers want to see if these agents can find tumors and their spread more accurately than current methods. About 200 women with breast cancer or suspected breast cancer will take part…

This study is testing a new 3D automated ultrasound system (ATUSA) for breast imaging. It will enroll up to 800 women with suspicious breast findings who are scheduled for a biopsy. The goal is to see if ATUSA can accurately detect breast cancer and monitor treatment response, of…

This study tests whether a newer PET tracer, 68Ga-FAPI-46, finds more cancer spots than the standard tracer in people with ER-positive breast cancer. About 20 women with advanced or recurrent breast cancer will get both types of scans. The goal is to see if the new tracer leads t…

This study looks at whether adding a special dye to mammograms every two years helps find breast cancer earlier in women who have already had it. About 1,500 women will get both a standard 3D mammogram and a contrast-enhanced mammogram. The goal is to see if the new method catche…

This study tests a new handheld robotic tool, HandX, to help surgeons perform a nipple-sparing mastectomy through a single small side incision. The goal is to reduce scarring, pain, and recovery time while keeping the breast's appearance. About 15 women already scheduled for mast…

This study tests whether a steroid mouthwash (dexamethasone) can reduce mouth sores caused by the cancer drug datopotamab deruxtecan. About 60 adults with advanced breast or lung cancer will use the mouthwash four times a day for the first five days of each treatment cycle. The g…

This study compares two exercise programs for women who have finished breast cancer treatment. One group does supervised resistance and relaxation exercises at a facility, while the other follows a home-based resistance routine. The goal is to see which approach better improves m…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study tests whether a program of exercise and personalized nutrition before breast cancer treatment (called prehabilitation) can help women recover faster and feel better. Researchers will measure fitness, strength, and quality of life in 66 women with early-stage breast can…

This study tests if a community exercise program can improve memory, attention, and brain health in breast cancer survivors. Researchers will compare exercise to health education in 160 women aged 50+ who finished treatment 3-36 months ago. The goal is to find a safe, accessible …

This study is testing whether a detailed PET/MR scan using a radioactive tracer called fluorocholine can predict the molecular subtype and likely outcomes of breast cancer. Researchers will scan 195 women before they start treatment and compare the images with their actual tumor …

This study follows 1600 breast cancer patients for up to 15 years after radiotherapy to see if newer, more precise radiation techniques lower the risk of heart disease. Researchers will compare heart problems in these patients to those in the general female population. The goal i…

This study looks at genetic markers on breast cancer cells before and after chemotherapy. Researchers want to see how these markers change and whether they can predict if the cancer will come back. About 300 adults with stage II to IV breast cancer will take part. The goal is to …

This study is testing whether an artificial intelligence (AI) tool can accurately predict a woman's genetic risk of developing breast cancer by analyzing her family cancer history. Researchers will compare the AI's predictions with standard genetic test results in 800 women who h…

This study explores why some breast cancer patients get diarrhea from the drug abemaciclib while others don't. Researchers will compare the gut bacteria of 60 women who do and don't have this side effect. No new treatments are tested—just stool and blood samples are collected to …

This study takes tumor samples from breast cancer that has spread to the brain or other parts of the body and grows them in the lab as mini tumors called organoids. Researchers will test whether these organoids can predict how well a patient's cancer responds to chemotherapy and …

This study is for people with early-stage or locally advanced breast cancer. It tests whether adding new drugs to standard chemotherapy before surgery can improve outcomes. By analyzing MRI scans, tissue, and blood samples, researchers hope to match each patient with the most eff…

This study looks at whether a protein called SGLT2 is linked to heart problems caused by a common breast cancer chemotherapy drug. Researchers will measure SGLT2 levels in blood and cells from 50 patients before and after treatment. The goal is to find better ways to identify who…

This study is not testing a new treatment. Instead, it gathers information from about 1,800 people with advanced breast cancer to learn more about the different types of the disease and how it affects patients. Researchers will look at medical records to understand patient charac…

This study follows 30 women having DIEP flap breast reconstruction after mastectomy. Researchers will measure inflammation and stress markers in blood samples taken before and after surgery. The goal is to learn how the body heals and what affects recovery, which may help improve…

This study looks at whether adjusting the dose of chemotherapy drugs (5-FU or capecitabine) based on a patient's DPYD gene test can reduce severe side effects. About 100 adults with certain cancers (like colorectal or breast) will be assigned to either a dose adjusted to their ge…

This study is testing a mobile decision aid for breast cancer patients who have had surgery. 20 participants will use the tool on their phones while researchers observe and ask for feedback. The goal is to see if the tool is easy to use and helps patients understand their reconst…

This study enrolls 3,300 women with invasive breast cancer living in 59 North Carolina counties. It aims to understand how tumor biology, healthcare access, and patient behavior together affect outcomes. All participants receive a structured program to improve communication with …

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study follows 1000 young women (ages 18-45) with breast cancer to learn more about fertility preservation options and pregnancy outcomes. Researchers will track which fertility treatments patients choose, how well they work, and the safety of having a baby after or during br…

This study aims to create a computer-based tool that can predict which cancer patients are at higher risk for heart problems from certain chemotherapy or targeted therapies. Researchers will collect data from 600 patients over one year and use machine learning to build a risk sco…

This study aims to understand why breast cancer risk and outcomes differ among people. Researchers will collect surveys, blood, and tissue samples from 800 adults in South Florida. The goal is to find genetic and non-genetic factors that may explain these differences.

This study is observing about 800 adults with advanced breast cancer (HER2-positive, low, or ultralow) who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers are tracking how long patients stay on the drug before switching treatment…

This study follows 100 women with early-stage breast cancer for two years after surgery and other treatments. Researchers will measure changes in muscle mass and body fat using a special scale. The goal is to understand how the body changes during recovery, which may help improve…

This study takes tumor samples from people with triple-negative breast cancer, colorectal cancer, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to provide person…

This study will test how well artificial intelligence (AI) can interpret breast ultrasound images using the latest BI-RADS criteria. Researchers will collect over 1,300 past ultrasound images with confirmed diagnoses and have expert radiologists annotate them. Then, various AI mo…

This observational study tracks how the lymphatic system changes after radiotherapy in 40 women with breast cancer. Researchers use a safe dye and special imaging to spot early signs of lymphedema (arm swelling). The goal is to find which patients might benefit from early prevent…

This study follows 3000 women with early-stage breast cancer to understand how treatments like surgery, chemo, and radiation affect their quality of life and cause side effects over time. Participants will fill out surveys about their well-being and undergo heart, lung, and blood…