BREAST NEOPLASMS

This study tests whether a combination of two hormone-targeting drugs (ribociclib and letrozole) can work as well as standard chemotherapy when given before surgery for postmenopausal women with a common type of breast cancer (hormone receptor positive, HER2 negative). About 100 …

This phase 3 study tested whether adding the drug abemaciclib to standard hormone therapy (fulvestrant) helps women with a common type of advanced breast cancer (HR+, HER2-) live longer without their cancer growing. About 669 women took part, receiving either the combination or f…

This study compares a 1-week radiation course to a standard 3-week course for women with node-positive breast cancer. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back while reducing the risk of lymphedema (arm swelling). About…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help people with a common type of advanced breast cancer (HR+/HER2-) live longer without their cancer getting worse. About 340 participants who have already tried hormone therapy wil…

This early-stage study tests the safety of tucatinib in about 25 Chinese patients with advanced HER2+ breast, stomach, or colorectal cancer that has worsened after standard treatments. Researchers will monitor side effects and how the drug moves through the body. The goal is to s…

This early-stage study tested the safety of a new drug called abemaciclib when combined with various other breast cancer treatments. It involved 198 people whose breast cancer had spread to other parts of the body. The goal was to see if these combinations were safe enough to stu…

This study tests whether a drug called trastuzumab deruxtecan (T-DXd), given alone or with other medications before surgery, works better than standard chemotherapy for people with high-risk HER2-positive early breast cancer. About 927 adults will take part. The main goal is to s…

This study tests whether a shorter, more focused radiation treatment (accelerated partial breast irradiation) after breast-conserving surgery can effectively control cancer in the breast and nearby lymph nodes for people with early-stage breast cancer. About 537 participants with…

This early-stage study tests an experimental pill, ATV-1601, for people with advanced solid tumors or certain breast cancers that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the body processes it. About 134 ad…

This study tests whether adding a targeted drug (PD 0332991) to standard hormone therapy (anastrozole) before surgery can better stop breast cancer cell growth in women with early-stage ER+ HER2- breast cancer. About 84 women with stage 2 or 3 disease will receive the combination…

This early-phase study tests a new drug called LY3484356 in 17 Chinese patients with a specific type of advanced breast cancer (ER+, HER2-). The main goal is to see how the drug moves through the body and how safe it is. Researchers will also check if the drug can shrink tumors. …

This early-stage study tests a new drug (H3B-6545) combined with an existing drug (palbociclib) in women with advanced or metastatic ER+ HER2- breast cancer. The main goal is to find the safest dose and understand side effects. About 31 women who have already tried other treatmen…

This study tests a new drug called PF-07220060 in people with advanced solid tumors, including breast, prostate, lung, and liposarcoma cancers. The drug is given alone or with hormone therapies to see if it is safe and works. About 362 participants will take part to find the best…

This early-phase trial tests a new drug called E7090, alone or with other cancer medicines, in people with a certain type of advanced breast cancer (ER+, HER2-). The main goal is to find safe doses and check for side effects. About 51 participants will take part to help guide fut…

This study tests three drugs—durvalumab, olaparib, and cediranib—given together to people with advanced solid tumors or recurrent ovarian cancer. The goal is to see if these combinations can shrink tumors or slow cancer growth. Participants take the drugs by IV or mouth daily, an…

This study tests whether adding alpelisib to standard fulvestrant therapy can delay cancer growth in Chinese men and postmenopausal women with a certain type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that worsened after prior hormone therapy. About 69 partici…

This study tests whether adding different immunotherapy drugs to standard chemotherapy before surgery can improve the chance of eliminating all cancer in people with triple negative breast cancer. About 12 adults with this aggressive breast cancer type will receive pembrolizumab …

This study tests a new drug called imlunestrant against standard hormone therapy in 8,000 people with early-stage, hormone-sensitive breast cancer who have already had 2 to 5 years of hormone treatment and still have a higher risk of their cancer returning. The goal is to see if …

This study tests a new drug called 9-ING-41, which targets a protein (GSK-3β) that helps cancer grow. It is for adults with advanced cancers that have not responded to standard treatments. The drug is given alone or with chemotherapy to see if it is safe and helps shrink tumors o…

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like bladder, breast, lung, or ovarian cancer) that have a protein called Nectin-4. The main goals are to check safety, find the right dose, and see if the…

This study tests whether contrast-enhanced mammography (CEM) finds breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women ages 30-85 will get both types of mammograms to compare detection rates and false alarms. The …

This study compares ultrasound and breast MRI to see which is better at finding cancer in women with dense breasts who have had breast cancer before. About 1,756 women are taking part. The goal is to improve how we check for new cancers in this high-risk group.

This study aimed to see if a physical therapy program focused on neck exercises could improve motor control, reduce pain, and enhance mood and quality of life in women who had breast cancer at least five years ago. Participants were to be adults over 18 with stage I to IIIA breas…

This study looks at whether a combination of pain neuroscience education and motivational interviewing can reduce chronic pain in breast cancer survivors who feel a sense of injustice about their pain. 156 women who have finished primary cancer treatment will be randomly assigned…

This study tests a program that combines pain education with gradual, guided activity to help breast cancer survivors manage long-term pain. About 122 survivors will either receive this program or standard care (an information leaflet). The goal is to see if the program reduces p…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This study reviews medical records of 88 women who had two-stage breast reconstruction after mastectomy for breast cancer. Researchers compare complications between nano- and microtextured tissue expanders and examine how prior radiotherapy impacts results. The goal is to identif…

This study uses tumor and blood samples from 1,000 breast cancer patients to create a model that predicts how well immunotherapy will work. Researchers will analyze genes, proteins, and other markers to find patterns linked to treatment success. The goal is to help doctors choose…

This study looks at whether checking lymph nodes for cancer during breast cancer surgery (frozen section) helps doctors decide right away if more lymph nodes need to be removed. About 142 women with breast cancer who haven't had prior treatment will take part. The goal is to see …

This study tests a web-based tool called gp-multitool.de that helps family doctors follow national guidelines for older patients with multiple chronic conditions like diabetes, heart disease, and depression. About 659 patients from various doctor practices in Germany are taking p…

This study observes over 1,400 people with a common type of advanced breast cancer (HR+/HER2-) who are receiving standard first-line treatment with palbociclib plus hormone therapy. Researchers are tracking how long the cancer stays under control and overall survival, using real-…

This study looks at how body fat influences breast cancer in 150 patients. Researchers will measure fat levels, analyze blood and tumor tissue, and track diet and activity. The goal is to better understand the link between obesity and breast cancer, not to test a new treatment.

This study looks at whether certain lab-made antibodies can spot breast cancer markers in blood samples. Researchers will collect blood from about 84 women, including those with early or advanced breast cancer and healthy volunteers. The goal is to improve how we detect cancer ce…

This study collects blood and saliva samples from people with cancer and their relatives to learn about genetic causes of cancer. Researchers will store these samples to study inherited cancer risks. About 992 participants will provide samples and family cancer history. The goal …

This study looks at whether certain women with early-stage breast cancer can skip radiation after a lumpectomy. The participants are postmenopausal, have a specific low-risk tumor type, and plan to take hormone therapy. Researchers will follow them for 10 years to see how many ha…

This study looks at whether it is safe to have an MRI scan when you have breast tissue expanders in place. About 68 people with these expanders will be scanned, and researchers will check for any burning, heating, or pain. The goal is to see if MRI can be done safely in this grou…

This study looks at how breast cancer and its treatments change the daily lives of 133 patients in Martinique. Researchers will use surveys to measure quality of life and track how long treatment takes. The goal is to find ways to improve care and support for future patients.

This study surveys 3,000 women aged 40 and older in Chinese communities to find out how many regularly perform breast self-exams and what factors influence their practices. Researchers use a health belief model to understand awareness, barriers, and motivations. The goal is to id…