BREAST NEOPLASMS

This study tested whether adding the drug palbociclib to standard hormone therapy (letrozole) helps slow the growth of advanced breast cancer in Asian women who have gone through menopause. The trial included 340 women whose cancer had not been treated before. Results showed that…

This study tested leflunomide, a pill usually used for arthritis, in 17 women with metastatic triple negative breast cancer (a fast-growing type). The goal was to see if it is safe and can help control the cancer. The drug works by blocking a protein the cancer needs to grow.

This early-phase study tested a new drug called H3B-6545 in 33 Japanese women with a common type of breast cancer (ER-positive, HER2-negative). The main goal was to see if the drug is safe and tolerable, and to find the right dose for Japanese patients. Participants had already t…

This study tested several immunotherapy-based drug combinations in 144 people with advanced hormone receptor-positive, HER2-negative breast cancer that had worsened after initial treatment with CDK4/6 inhibitors. Participants received either a standard hormone therapy (fulvestran…

This study followed 80 Egyptian women with HER2-positive breast cancer to see how well anti-HER2 drugs (like trastuzumab) work in real-world settings. Researchers tracked survival, cancer progression, and side effects. The goal was to understand how these targeted therapies perfo…

This early-phase study tested an experimental drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and to find the best dose. Researchers als…

This study looked at 140 women with early-stage breast cancer to compare two radiation methods after surgery: a shorter, more focused radiation (accelerated partial breast irradiation) versus standard whole breast radiation. The goal was to see which causes fewer side effects lik…

This study tested whether a contrast-enhanced mammogram (angiomammography) can predict if breast cancer will fully disappear after chemotherapy. 67 women with breast cancer had imaging after two rounds of chemo. The goal was to see if this method could identify non-responders ear…

This study looked at whether a fast (abbreviated) breast MRI can detect breast cancers that are not seen on standard mammograms in women who have previously had breast-conserving therapy for breast cancer. 184 women who had a normal mammogram within the past six months were recru…

This study tested whether an AI program called CadAI-B Dx helps doctors more accurately detect breast cancer on ultrasound images. Researchers had 16 doctors review 797 breast ultrasound cases (350 with cancer, 447 benign) both with and without the AI's help. The goal was to see …

This study tested an AI system called Carebot AI MMG to see if it can detect breast cancer from mammograms as well as human radiologists. Researchers used 222 past mammograms from four screening centers. The AI was compared to three experienced radiologists to measure its accurac…

This study tested whether injecting a local anesthetic (ropivacaine) during breast cancer surgery could prevent chronic pain that sometimes lingers for months. 260 women having breast-conserving surgery or mastectomy took part. The main goal was to see if fewer women reported bre…

This study looked at whether a home-based exercise program (aerobic and resistance training) could improve physical fitness, reduce fatigue, and enhance quality of life for 36 breast cancer patients in Indonesia. Participants exercised at home with phone supervision and visited t…

This study tested a remote monitoring system (CONTINUUM+ CONNECT) in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Participants used the system at home to track their health, with some also getting nursing support. The goal was to see if this approach i…

This study looked at whether starting a tailored exercise program before breast cancer treatment can lessen heart damage and other side effects compared to exercising only during treatment. It involved 100 women recently diagnosed with breast cancer. The goal was to see if early …

This study tested a special program to help breast cancer patients manage joint and muscle pain caused by hormone therapy. The program was adapted to fit different cultural backgrounds. Researchers compared patients who received this program with those who got standard care to se…

This study looked at 80 adults having major breast cancer surgery to see which pain relief method works better: a nerve block (ESPB) or lidocaine given through an IV. The goal was to find which approach helps patients recover better and feel less pain after surgery. The results c…

This study looked at how breast cancer treatments affect sexual health in 25 women. Participants filled out anonymous questionnaires about their sexual function, quality of life, and emotional well-being before and after chemotherapy. The goal was to understand how these factors …

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This study looked at the vaginal microbiome (the community of tiny organisms living in the vagina) in 35 women with breast cancer who were receiving hormone therapy. The goal was to see if changes in these microbes could help predict or improve vaginal dryness and sexual health i…

This study reviewed medical records of 258 adults in Gulf countries (like Saudi Arabia and UAE) who took palbociclib for advanced HR+/HER2- breast cancer. Researchers collected information on patient characteristics, treatment patterns, and outcomes like how long the cancer staye…

This study reviewed medical records of 517 women with advanced breast cancer in Gulf countries to find out how many had a newly recognized type called HER2-low. The goal was to better understand this subtype's features and how common it is. No new treatments were tested; the stud…

This study looked at medical records from 1128 Australian patients to see how doctors prescribe CDK4/6 inhibitors (like palbociclib) for advanced or metastatic breast cancer. Researchers examined patient ages, other health conditions, and which combinations of medicines were used…

This study looked at how common BRCA1 and BRCA2 gene mutations are in Hispanic/Latino women with breast cancer. Researchers collected saliva samples and medical history from 266 participants to better understand these mutations in this group. No treatment was given; the goal was …

This study tested whether a special 3D ultrasound technique (Shear Wave Elastography) can accurately predict how well breast tumors respond to chemotherapy before surgery. Researchers measured tumor stiffness at several points during treatment in 140 women with locally advanced b…

This study observed 440 adults in Poland with a common type of advanced breast cancer (HR+/HER2-). Researchers tracked which treatments patients received and how those treatments changed over a year. The goal was to understand real-world care, not to test a new drug.

This study tested whether a smartphone app could help monitor side effects in 28 women with metastatic breast cancer who were taking oral chemotherapy drugs like palbociclib, everolimus, or capecitabine. The goal was to see if the app could reduce the number of calls to nurses an…

This study looked at whether people with unstable living conditions are more likely to be diagnosed with advanced breast cancer. Researchers compared 684 patients with early-stage versus late-stage breast cancer. They found that social fragility may be linked to a later diagnosis…

This study looked at whether a special 'remission' consultation helps women feel better after finishing breast cancer treatment. Fifty patients who had completed chemotherapy or radiation joined the study. Researchers checked their quality of life and body image at 3, 6, and 12 m…

This study examined 52 breast cancer tumor samples and some blood samples to find unique chemical patterns (metabolites) that could help doctors better understand different types of breast cancer. The goal was to identify new markers that might lead to simpler, cheaper tests or n…

This study looked at 729 breast cancer patients who had radiation after surgery to see how many developed an underactive thyroid (hypothyroidism). Researchers checked thyroid function before and after radiation to find risk factors and understand the link between radiation dose a…

This study looked at 77 women with breast lesions that only show up on contrast-enhanced mammography. Doctors performed special biopsies guided by contrast imaging to find out the smallest number of tissue samples needed for a reliable diagnosis. The goal is to reduce unnecessary…

This study looked at why some women have dense breasts on mammograms and why that increases their risk of breast cancer. Researchers collected tissue samples, medical records, and health updates from 466 women aged 40-65 who were having a breast biopsy. The goal was to understand…