AUTISM SPECTRUM DISORDER

This study tests whether low doses of interleukin-2 (ILT-101) can help children aged 6 to 8 with autism spectrum disorder whose mothers had an immune condition during pregnancy. The treatment aims to boost certain immune cells (Tregs) that may be out of balance. The trial involve…

This early-phase study tests a new treatment called VGN-Ex05e for children and teens with autism who have severe, treatment-resistant self-injury or aggression. Six participants aged 7 to 18 will receive a single injection into a brain region linked to reward and behavior. The ma…

This study will test if an artificial intelligence (AI)-powered electric toothbrush, paired with picture-based teaching materials, can improve oral hygiene in children with autism spectrum disorder (ASD). Fifty children aged 5 to 13 will be randomly assigned to use either a manua…

This study tests a brain implant called deep brain stimulation (DBS) to help control severe aggression in people with autism or schizophrenia who have not responded to any other treatment. Six adults who have been in locked psychiatric units for months will receive the implant. T…

This study tests a treatment called FBET to reduce elopement (wandering away) in children aged 4-12 with autism. About 50 children will receive 12 therapy sessions over 20 weeks, either with FBET or standard care. Researchers want to see if FBET is practical in community clinics …

This study explores whether eye-tracking technology can help screen for autism in children aged 4 to 10. Researchers will compare how children with and without autism look at faces and other social cues. The goal is to create a simpler, language-free diagnostic tool for kids who …

This study looks at whether training primary care doctors to diagnose autism in children aged 18 to 36 months can shorten the time from a positive screening to a final diagnosis. About 300 children will take part across multiple clinics. Some doctors will receive special training…

This study will test whether a machine-assisted system can help screen toddlers for autism early. Researchers will compare the system's results with standard clinical diagnoses in 1,000 children aged 1.5 to 2.5 years. The goal is to see if the system can accurately tell apart aut…

This study tests whether a full-spectrum cannabis plant extract called NTI164 can help reduce core autism symptoms like social difficulties and repetitive behaviors. About 98 children and young adults aged 6 to 25 with moderate to severe autism will receive either NTI164 or a pla…

This study will test a behavioral program to improve sleep and daily rhythms in autistic adults aged 18-65 who have sleep problems. The goal is to see if the treatment can improve overall sleep health and well-being. The study involves 24 participants and focuses on making the pr…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can reduce stomach issues like constipation and pain in 20 children with autism, aged 6-12. Half will get the real treatment in capsules, half a placebo, after a bowel cleanse. Research…

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. About 20 participants will receive buspirone or a placebo for 16 weeks. The goal is to see if the drug reduces anxiety symptom…

This study tests a device that sends gentle magnetic pulses to the brain to see if it can improve social skills and reduce repetitive behaviors in children with autism. About 256 children aged 3 to 12 will either get real or fake (placebo) sessions for 28 days. The goal is to fin…

This study tests whether an online course in Spanish can teach parents of young children with autism how to use Pivotal Response Treatment (PRT) to improve their child's language and social skills. About 40 Spanish-speaking families with children aged 2 to 5 will take online less…

This study tests whether a special app can help children and teens (ages 8-17) with autism improve their toothbrushing. Participants will use either the autism-friendly app or a basic control app for 3 months. Researchers will check if the app leads to better brushing coverage, l…

This early-stage study tests whether a single intravenous dose of stem cells from donated bone marrow is safe for children and adults (age 6+) with autism spectrum disorder. Researchers will also look for early signs that the treatment might improve behavior, social skills, and d…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The goal is to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 years will take part…

This early-stage study tests whether a non-invasive ultrasound device can safely stimulate a deep brain region in 20 people with autism aged 13-25. Researchers will check for side effects and measure changes in social skills, emotion recognition, and brain activity. The goal is t…

This study tests whether a rhythmic auditory training program can improve language skills in children with Autism Spectrum Disorder (ASD) who have language delays. Twenty-four children aged 3 to 6 will practice reproducing the syllable rhythms of speech. Their language abilities …

This study tests a mobile app called "Heart Voice: Starry Journey" designed to help parents and caregivers of children with autism feel more flexible and less stressed. About 52 caregivers will use the app for 6 weeks, doing interactive stories and exercises based on acceptance a…

This study tests a social skills program called PEERS® for Italian teenagers with autism spectrum disorder (ASD) aged 10 to 14. The program teaches teens how to make and keep friends, handle social media, and use humor appropriately. Researchers will also check if brain activity …

This study tests a personalized program for mothers who care for a child with autism. The program helps them manage stress, find time for meaningful activities, and build healthy habits. Researchers will measure if it improves their wellbeing and reduces caregiver burden over 6 m…

This study tests a computer-based training program called action-based cognitive remediation (ABCR) to see if it can improve thinking, social, and work skills in people with various psychiatric conditions like depression, schizophrenia, and PTSD. 160 participants will first wait …

This study tests a short, guided self-help program designed to help parents of autistic children (ages 6-17) manage stress and improve well-being. Parents will read workbook materials, listen to audio tracks, and have weekly support calls with a researcher over about 13 weeks. Th…

This early-stage trial tests whether a 6-week course of vancomycin followed by a fecal transplant from a family member can improve social and language delays in adults with autism. Ten participants with gastrointestinal symptoms will be monitored for changes in autism symptoms an…

This study will test a new program that combines a digital app for children with autism (ages 5-8) and online coaching for their parents. The goal is to help kids improve skills like paying attention, following instructions, and controlling impulses. About 40 families in South Ko…

This study tests whether the anti-inflammatory drug prednisone can improve core autism symptoms in adult males with a specific immune-related form of autism. Over 16 weeks, 32 participants will receive either prednisone or a placebo, with regular checkups and remote calls. The go…

This study tests a visual safety plan designed for autistic teenagers aged 13-18 who have had recent suicidal thoughts or self-harm. About 90 participants will either get the visual plan plus standard care or standard care alone. Researchers will check if the plan is easy to use,…

This study looks at how a single dose of MDMA (the active ingredient in ecstasy) changes oxytocin levels in the blood of 40 adults—half with autism spectrum disorder and half without. Researchers want to see if the oxytocin response differs between the two groups. The goal is to …

This study will test a special language teaching method for infants aged 6-12 months who have an older sibling with autism. These infants are at higher risk for autism or language delays. The method encourages babies to look at their caregiver's mouth during play, which may help …

This study tests a new training tool called KF-STRIDE 3.0 to help adults with autism improve their job interview skills. About 30 participants will do a mock interview and be rated on how likely they are to be hired. The goal is to see if the tool is easy to use and helpful, so i…

This study tests an online program for 40 caregivers of children aged 7-12 with autism in South Korea. The program helps caregivers prepare to tell their child about the diagnosis. Researchers will check if the program is helpful and easy to use, and if it improves caregivers' we…

This study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. Researchers will use eye-tracking experiments to measure emotion recognition and regulation. Then, 40 participants with intellectu…

This study looks at how emotions change throughout the menstrual cycle in autistic women. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and those without any condition. The goal is to better understand emotional ups …

This study tests a new computer program designed to help autistic children ages 8-11 improve their ability to control thoughts and actions, which may reduce repetitive behaviors. About 95 children will be randomly assigned to receive the training right away or after a delay. Rese…

This study looks at how children with autism spectrum disorder (ASD) perceive time and pay attention. Researchers will use eye-tracking to compare 3- and 5-year-olds with ASD to typically developing children. The goal is to understand if kids with autism process visual informatio…