Toxemia of pregnancy

This trial tests whether a low-sodium diet can improve blood pressure control in people who had a hypertensive disorder of pregnancy. Participants receive either a provided diet with less than 2000 mg of sodium per day or a standard diet with no salt restrictions for the first we…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This pilot study tests whether adding dipyridamole, an approved drug that improves blood flow, to standard care is feasible and safe for pregnant women with early-onset preeclampsia. The trial will enroll 15 hospitalized women between 26 and 34 weeks of pregnancy with high levels…

This study tests whether a patient navigator — a trained staff member who helps connect people with health services — can improve long-term heart health for those who had high blood pressure disorders during pregnancy. About 60 participants will be randomly assigned to receive ei…

This study tests whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide the best time to deliver babies in women with severe early-onset preeclampsia. The trial will include 386 pregnant women between 30 and 34 weeks of gestation. Half will have delivery tim…

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This study tests whether combining a Bluetooth blood pressure monitor with regular support from a community health worker can help Black women control high blood pressure after pregnancy. About 404 women will be randomly assigned to either this extra support or standard care. The…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether a quick bedside ultrasound can help doctors decide if new mothers with preeclampsia need a diuretic (water pill) to lower their blood pressure. About 96 postpartum patients will be enrolled. The goal is to see if this approach speeds up blood pressure rec…

This early-stage trial tests a new drug called EG-101 in 24 healthy women to make sure it is safe before trying it in pregnant women with severe pre-eclampsia, a dangerous condition that causes high blood pressure and organ damage. The study will measure how the drug moves throug…

This study tests two progestin-only birth control pills—drospirenone and norethindrone—to see which one helps control high blood pressure after a pregnancy complicated by preeclampsia. Fifty women will take one of the pills daily for six weeks after leaving the hospital. The goal…

This study looks at whether showing women detailed pictures of their own blood vessels can motivate them to make healthier choices after having pregnancy complications like preeclampsia or gestational diabetes. About 318 women will be split into two groups: one gets the visual fe…

This study tests whether breathing in a sedative called dexmedetomidine before anesthesia can prevent sudden blood pressure rises during emergency C-sections in women with severe preeclampsia. One hundred participants will be randomly assigned to receive either the drug or a plac…

This study looks at whether a noninvasive finger monitor can predict how pregnant women, including those with severe preeclampsia, respond to fluids. Researchers will compare the finger device to standard heart ultrasound in 88 women. The goal is to find a simpler way to guide fl…

This study looks at whether a substance in the blood called sCD163 can help doctors find HELLP syndrome early in pregnant women. HELLP is a rare but serious condition that can harm the liver and blood. Researchers will compare sCD163 levels in 70 pregnant women—some with HELLP an…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This study looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Over 15,000 women across Europe and Africa will be randomly assigned to stop or continue aspirin. The goal is to see …

This study tests whether notifying obstetric clinicians when a pregnant patient is at high risk for preeclampsia increases the use of low-dose aspirin, which can help prevent the condition. Researchers will compare clinics that receive these alerts to those that continue usual ca…

This study tests whether taking 2,000 IU of vitamin D daily during pregnancy can prevent preeclampsia, eclampsia, and HELLP syndrome in about 2,000 pregnant women in Uganda. Half the women will receive vitamin D and half a placebo, and researchers will track outcomes up to six we…

This study tests an injection called topefilgrastim in 100 pregnant women at high risk for preeclampsia, a serious condition that can harm both mother and baby. Participants are split into two dose groups or a control group to see if the drug can lower the chance of developing pr…

This study tests whether a higher dose of aspirin (150mg) is better than the usual dose (75mg) at preventing preeclampsia, a serious condition involving high blood pressure during pregnancy. The trial will include 86 pregnant women in Kathmandu who are at high risk based on a sco…

This study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …

This study will test whether 150 mg of aspirin works better than 75 mg to prevent preeclampsia in pregnant women at high risk. About 340 women aged 18-30 with a single pregnancy will take aspirin nightly from early pregnancy. The main goal is to see which dose reduces the chance …

This study tests whether a common water pill (furosemide) can help women with severe preeclampsia recover faster after childbirth and leave the hospital sooner. About 186 women will receive either furosemide or a placebo starting 12 hours after delivery. The goal is to see if the…

This study looks at whether beetroot juice can quickly lower blood pressure in pregnant women with pre-eclampsia, a serious condition causing high blood pressure. Researchers will give beetroot juice or a placebo to 60 pregnant women and measure changes in blood pressure, blood m…

This study looks at whether stretching or aerobic exercises can help women with mild preeclampsia. Sixty first-time pregnant women, ages 20-30, will do one type of exercise for six weeks. Researchers will measure blood pressure and urine protein levels to see which exercise works…

This study looks at whether pregnant women at high risk of preterm birth can safely express breastmilk from week 28 to 34 of pregnancy. Researchers will check if it affects how soon the baby is born, how much milk is available at birth, and whether it helps with breastfeeding. Th…

This study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…

This study investigates genetic and molecular markers in pregnant women with severe preeclampsia, a dangerous condition involving high blood pressure and organ damage. Researchers will analyze blood, urine, and placental samples from 100 women to identify changes in genes and cel…

This study tracks how a pregnant person's heart and lungs change over the course of pregnancy and after childbirth. Researchers will use non-invasive tests to measure blood flow and airway function, aiming to understand how these changes relate to the development of preeclampsia,…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This study looks at whether allied-health professionals (like pharmacists or nurses) can help recruit and follow women who had preeclampsia during pregnancy. Participants will check their blood pressure at home and work with a research pharmacist for 12 months. The goal is to see…

This study compares three ways of teaching midwifery students about preeclampsia and eclampsia: a digital game, a simulation, and traditional lectures. The goal is to see which method boosts knowledge, motivation, and attitude the most. 120 fourth-year midwifery students will tak…

This study from the University of Oxford will follow 360 pregnant women to see if hormone levels and ultrasound images from the first 8 weeks can predict pre-eclampsia. Pre-eclampsia is a dangerous complication that affects many pregnancies worldwide. The goal is to find early wa…

Severe preeclampsia is a dangerous pregnancy complication that can cause high blood pressure, harming both mother and baby. This observational study will follow 350 women to identify factors that make blood pressure control with the drug labetalol fail. By understanding these fac…

This study will check if an ultrasound of the internal jugular vein in the neck can predict a sudden drop in blood pressure during spinal anesthesia for C-section in women with preeclampsia. Researchers will measure the vein's collapsibility before surgery and track blood pressur…

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This study looks for proteins in the blood that might show early heart changes in women with preeclampsia, a serious pregnancy condition. Researchers will also use heart ultrasounds to see how the heart changes during pregnancy. The goal is to find ways to predict future heart pr…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…

This study will check if certain blood markers (like platelet counts and inflammation levels) can help predict serious complications in pregnant women with HELLP syndrome, a rare but dangerous condition. Researchers will follow 60 women to see how these markers relate to problems…

This study will test whether a formula called fullPIERS can accurately predict serious complications in 50 pregnant women with preeclampsia. The formula uses information like blood pressure, kidney function, and symptoms to estimate risk. If it works well, doctors could use it to…

This study will follow 120 pregnant women with high blood pressure or preeclampsia to see if certain ultrasound scans and blood tests can predict who will develop severe disease. Researchers will measure blood flow in the mother's heart, eyes, and womb, along with lung ultrasound…

This study aims to understand what causes preeclampsia, a serious pregnancy condition. Researchers will measure a protein called sFlt1 in the blood of 500 women, including those with and without the condition. The goal is to find better ways to diagnose and treat this disease in …

This study looks at how certain gene combinations (HLA-C and KIR) might affect the risk of preeclampsia in pregnancies from egg donation. Researchers will collect cheek swabs from mothers, children, and egg donors to analyze DNA. By comparing gene patterns between those who devel…