Toxemia of pregnancy

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study tests whether giving blood pressure medication to women after childbirth can prevent hospital readmissions and reduce severe high blood pressure. About 300 women with preeclampsia will either receive standard care or start blood pressure drugs like labetalol or nifedip…

This study tests whether intensive blood pressure treatment after childbirth can improve women's long-term heart health. Researchers will enroll 60 women who had high blood pressure during pregnancy and give them nifedipine to keep their BP below 140/90 mmHg. The goal is to see i…

This study looks at whether starting daily low-dose aspirin in the first trimester (weeks 1–12) is safer and more effective than starting in the second trimester (weeks 13–27) for pregnant women with sickle cell disease. Researchers will track maternal deaths, preterm births, and…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study tests whether a specially designed app can help women who had high blood pressure or diabetes during pregnancy get the recommended heart check-ups after giving birth. About 400 women from Oslo University Hospital will either use the app or receive standard care. The go…

This study tests whether hydroxytyrosol, a natural antioxidant from olives, can improve blood vessel function in pregnant women with high blood pressure. Fifty-two women will take either the supplement or a placebo for 4 weeks. Researchers will measure changes in blood markers an…

This study tests a new urine test called CercaTest™ Red to predict preeclampsia in pregnant women who show signs of the condition. Preeclampsia is a serious complication involving high blood pressure and organ damage. The test is designed to be used at the point of care, giving q…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This study tests whether providing fresh meals, health coaching, and education to high-risk pregnant women can reduce the chance of developing gestational diabetes, high blood pressure, or preeclampsia. 69 women in Milwaukee are randomly assigned to either receive the program or …

This study tests whether using a smartphone app and a home blood pressure monitor can help prevent heart disease in women who had high blood pressure during pregnancy. 120 women who gave birth at Northwestern Memorial Hospital will use these digital tools for 12 months after deli…

This study investigates how aspirin can prevent preeclampsia, a serious pregnancy condition, in first-time mothers at high risk. Researchers will compare biological changes in 200 women with low or high risk, some taking aspirin and some not. The goal is to understand how aspirin…

This pilot study tests whether remote monitoring and guideline-directed therapy can prevent heart dysfunction in African American women who had preeclampsia. Twenty participants will use a tablet, blood pressure cuff, and scale at home for three months after delivery. The goal is…

This study tests whether taking L-citrulline, a natural amino acid supplement, daily from early pregnancy can prevent high blood pressure conditions like preeclampsia in women expecting their first child. About 338 healthy first-time mothers between 12-16 weeks pregnant will rece…

This study tests whether an 8-week phone-based mindfulness program can reduce stress and blood pressure in 150 pregnant women at risk for hypertensive disorders. Participants will complete daily surveys and wear biosensors to track stress and heart activity. The goal is to see if…

This study looks at whether progressive muscle relaxation and finger grip exercises can lower stress, anxiety, and fatigue while improving sleep in pregnant women with preeclampsia. About 90 women will be split into three groups: one doing relaxation exercises, one doing finger g…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

This study tests whether ultrasound of the lungs and a major vein (vena cava) can accurately measure fluid status in women with mild preeclampsia after they receive spinal anesthesia for delivery. Researchers will compare ultrasound findings to traditional methods in 62 participa…

This study is testing whether women with high-risk pregnancies can be safely monitored from home instead of staying in the hospital. Researchers will check if home monitoring is practical, safe, and costs less, while also improving patients' quality of life. About 250 pregnant wo…

This observational study aims to measure how well the heart pumps blood in people with untreated preeclampsia compared to healthy pregnant women. Researchers will use a non-invasive ultrasound (echocardiography) to check heart function at rest, after blood pressure medication, an…

This study looks at why women who had preeclampsia may have lasting blood vessel problems and inflammation. Researchers will test a drug called eplerenone on a small patch of skin to see if it improves blood vessel function. The study involves 40 women, some with a history of pre…

This study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …

This study gives 300 new mothers a medical-grade smartwatch that tracks blood pressure multiple times daily for 6 weeks after delivery. Researchers want to see if daily blood pressure patterns differ between low-risk, intermediate-risk, and high-risk groups. The goal is to better…

This study compares two ways of teaching people with preeclampsia about their condition: a new illustrated app versus standard hospital discharge instructions. About 36 participants will take a quiz to see which method helps them remember key facts and warning signs. The goal is …

This study aimed to see if providing medically tailored meals, lactation support, and food for children could help Black women with hypertensive disorders of pregnancy control their weight after childbirth. The trial was withdrawn before any participants were enrolled, so no resu…

This pilot study is testing a device called LabClasp that measures blood sugar without needles. Researchers want to see if regular, non-invasive glucose checks can help predict gestational diabetes and preeclampsia in pregnant women. The study plans to enroll 100 women with at le…